Effect of combinations of four trace elements on cadmium bioaccumulation in a few tissues of male albino rats
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Abstract
The present study is designed to investigate the accumulation of cadmium (Cd) in selected tissues such as liver, kidney, testis and small intestine of male albino rats treated for Cd and after combined supplementation with Zinc (Zn) + Iron (Fe) and Selenium (Se) + Copper (Cu). The wistar albino rats were treated with cadmium chloride(CdCl2)at a dose of 1/10th LD50 i.e. 22.5 mg / kg body weight for 7, 15 and 30 days(d) time intervals. After 15 d to Cd treatment, the rats were then supplemented with the above combination of two trace elements and then
observed for accumulation of Cd at specific time intervals. These trace elements at a dosage of 1 mg/ kg body weight of Se, 16mg/kg body weight of Cu, 12 mg / kg body weight of Zn and 40 mg / kg body weight of Fe were given as supplements. There was significant Cd accumulation in liver and kidney among the selected tissues before to supplementation and there was significant decrease in the Cd accumulation levels in all the tissues after trace element supplementation. Moreover the 30d Zn + Fe supplemented rat kidney showed maximum decrease in Cd accumulation (8.327?g/g wet wt. of the tissue).
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Casalino, E., Sesare Sblano and Clemente Landriscina. (1997). Enzyme activity alteration by cadmium administration to rats: The possibility of iron involvement in lipid peroxidation. Archives of Biochemistry and Biophysics, 346(2):171-179.
Chan, H.M. and Cherian, M.G.(1993). Mobiliziation of hepatic cadmium in pregnant rats, Toxicol. Appl. Pharmacol., 120: 308-314.
Combs, G. and Gray, W.P.(1998). Chemopreventive agents: selenium, Pharmacol Ther, 79: 179-192.
Flora, S.J.S., Megha Mittal and Ashish Mehta (2008). Heavy metal induced oxidative stress and its possible reversal by chelation therapy, Indian J Med Res, 128: 501-523.
Hakan Aydin, H., Canan Coker and Biltan Ersoz (2001). In vivo interaction between cadmium and essential trace elements copper and zinc in rats, Turk J Med Sci, 31: 127-129.
Haki Kara, Fikret Karatas, Halit Canatan (2005). Effect of Single Dose Cadmium Chloride Administration on Oxidative Stress in Male and Female Rats, Turk J Vet Anim Sci, 29: 37-42.
Hijova, E. and Nistiar, F.(2005). Plasma antioxidant changes after acute cadmium intoxication in rats, Acta Vet Brno, 74: 565-568.
Horiguchi, H., Oguma, E., Sasaki, S., Mimyamoto, K., Akeda, Y., Machida, M. and Kayama, F.(2005). Environmental exposure to Cadmium at a level insufficient to induce renal tubular dysfunction does not affect Bone density among female Japanese farmers, Environ. Res., 97: 83-92.
IARC, International Agency for Research on Cancer, Beryllium, cadmium, mercury and exposures in the glass manufacturing industry, (1993). In: International agency for research risks to humans, Lyon: IARC Scientific Publications, 58: 119-237.
Linde, A.R., Sanchez-Galan, S. and Garcia-Vazquez, E. (2004). Heavy metal contamination of European eel (Anguilla anguilla) and brown trout (Salmo trutta) caught in wild ecosystems in Spain, J. Food Prot., 67: 2332-2336.
Massanyi, P., Tataruch, F., Slamecka, J., Toman, R. and Jurcik, R.(2003). Accumulation of lead, cadmium, and mercury in liver and kidney of the brown hare (Lepus europaeus) in relation to the season, age, and sex in the West Slovakian Lowland, J.Environ. Sci. Health, A39: 1299-1309.
Mahtap Kocak and Ethem Akcil (2006). The effects of chronic cadmium toxicity on the hemostatic system, Pathophysiol Haemost Thromb, 35: 411-416.
Moniusko-Jakoniuk, J. and Brzoska, M.M. (1999). Environment pollution and Health, lek Wojsk, 75(7-8): 419-426.
Nad, P., Massanyi, P., Skalicka, M., Korenekova, B. and Cigankova, V. (2005). The effect of cadmium in combination with Zinc and selenium on ovarian structure in Japanese quails, Rizilove factory Potravoveho Refazca, V: 241-247.
Nordberg, G.F., Bigawam, K., Nordberg, M. and Friedmann, J.M. (2007). Cadmium. In: Hand book on the toxicology of Metals, (Nordberg GF, Fowler BA, Nordberg M, Friberg L, eds). Amsterdam: Elsevier, 445-486.
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Ognjanovic, B.I., Pavlovic,S.Z., Maletic,S.D., Zikic, R.V., Stajn, A.S., Radojicic R.M., Saicic, Z.S. and Petrovic,V.M.(2003). Protective influence of Vitamin E on Antioxidant Defence system in the blood of rats treated with Cadmium, Physiol. Res., 52: 563-570.
Petering, H.G., Murthy, L. and Cerklewski, F.L. (1977). Role of nutrition in heavy metal toxicity. In: Biochemical Effects on Environmental Pollutants (Lee SD ed). Ann Arbor, MI: Science Publishers.
Rodriguez-Matas, M.C., Lisboma, F., Gomez-Ayala, A.E., Lopez-Aliaga, I. and Campos, M.S. (1998). Influence of nutritional iron deficiency development on some aspects of iron, copper and zinc metabolism, Laboratory Animals Ltd. Laboratory Animals, 32: 298-306.
Salem Amara, Hafedh Abdelmelek, Catherine Garrel, Pascale Guirud, Thierry Douki, Jean-Luc Ravant, Alian Favier, Mohsen Sakly and Khemais Ben Rhouma (2008). Preventive effect of Zinc Against Cadmium-induced oxidative stress in the rat testis, Journal of Reproduction and Development, 54(2): 129-134.
Saric, M.M., Blanusa, M., Piasek, M., Varnai, V.M., Juresa, D. and Kostial, K. (2002). Effect of dietary cadmium on cadmium absorption and retention in suckling rats, Biometals, 15(2): 175-182.
Schumann, K., Friebel, P., Schmolke, G., Elsenhans, B.(1996). State of iron repletion and cadmium exposure. Arch. Environ. Contam. Toxicol., 31(4): 483-487.
Shuenn-Jiun Yiin, Chi-Liang Chern, Jenn-Yuan Sheu and Te-Hsien Lin. (1999). Cadmium induced lipid peroxidation in rat testes and protection by Selenium, BioMetals, 12, 353–359.
Shibutani, Makoto, Kunitoshi Mitsumori, Shin-ichi Satoh, Hideaki Hiratsuka, Masahiko Satoh, Masami Sumiyoshi, MotohiroNishijima, Yasutaka Katsuki, Jin Sujuki, Jun-ichi Nkagawa, Takumi Akagi, Takayoshi Imazawa and Masanori Ando (2001). Relationship between toxicity and cadmium accumulation rats given low amounts of Cadmium chloride or cadmium – polluted rice for 22 months, The Journal of Toxicological Sciences, 26(5): 337-358.
Siraj Basha, P. and Usha Rani, A. (2003). Cadmium induced antioxidant defense mechanism in fresh water teleost Oreochromls mossambicus (Tilapia), Ecotoxicol. Environ. Safety, 56: 218-221.
Tim S. Nawrot, Etienne Van Hecke, Lutgarde Thijs, Tom Richert, Tatiana Kuznestsova, Yu Jin, Jaco Vangronsveld, Harry A Roels and Jan A. Staessen (2008). Cadmium- Related mortality and long-Term Secular Trends in the Cadmium body burden of an Environmentally Exposed Population,Environmental Health Perspectives, 116(12): 1620-1628.
Trzcinka-ochocka, M., Zakubowski, M., Razniewska, G., Halatek, T. and Gazewaski, A. (2004). The effects of environmental Cadmium exposure on kidney function: the possible influence of age, Env. Res., 95: 143-150.
Usha Rani, A. (2000). Cadmium induced bioaccumulation in the tissues of fresh water teleost Oreochromis mossambicus., The Annals. N. Y. Acad. Sci., 919(1): 318 – 320.
Vahter, M., Berglund, M., Nermell, B. and Akesson, A.(1996). Bioavailability of cadmium from shellfish and mixed diet in women, Toxicol. Appl. Pharmacol., 136: 332-341.
Bonda, E., Wlostowki, T. and Krasowska, T. (2004). Testicular toxicity induced by dietary cadmium is associated with decreased testicular zinc and increased hepatic and renal metallothionein and zinc in the ban vole (Clethrionomys glareolus), Biometals, 17: 615-624.
Casalino, E., Sesare Sblano and Clemente Landriscina. (1997). Enzyme activity alteration by cadmium administration to rats: The possibility of iron involvement in lipid peroxidation. Archives of Biochemistry and Biophysics, 346(2):171-179.
Chan, H.M. and Cherian, M.G.(1993). Mobiliziation of hepatic cadmium in pregnant rats, Toxicol. Appl. Pharmacol., 120: 308-314.
Combs, G. and Gray, W.P.(1998). Chemopreventive agents: selenium, Pharmacol Ther, 79: 179-192.
Flora, S.J.S., Megha Mittal and Ashish Mehta (2008). Heavy metal induced oxidative stress and its possible reversal by chelation therapy, Indian J Med Res, 128: 501-523.
Hakan Aydin, H., Canan Coker and Biltan Ersoz (2001). In vivo interaction between cadmium and essential trace elements copper and zinc in rats, Turk J Med Sci, 31: 127-129.
Haki Kara, Fikret Karatas, Halit Canatan (2005). Effect of Single Dose Cadmium Chloride Administration on Oxidative Stress in Male and Female Rats, Turk J Vet Anim Sci, 29: 37-42.
Hijova, E. and Nistiar, F.(2005). Plasma antioxidant changes after acute cadmium intoxication in rats, Acta Vet Brno, 74: 565-568.
Horiguchi, H., Oguma, E., Sasaki, S., Mimyamoto, K., Akeda, Y., Machida, M. and Kayama, F.(2005). Environmental exposure to Cadmium at a level insufficient to induce renal tubular dysfunction does not affect Bone density among female Japanese farmers, Environ. Res., 97: 83-92.
IARC, International Agency for Research on Cancer, Beryllium, cadmium, mercury and exposures in the glass manufacturing industry, (1993). In: International agency for research risks to humans, Lyon: IARC Scientific Publications, 58: 119-237.
Linde, A.R., Sanchez-Galan, S. and Garcia-Vazquez, E. (2004). Heavy metal contamination of European eel (Anguilla anguilla) and brown trout (Salmo trutta) caught in wild ecosystems in Spain, J. Food Prot., 67: 2332-2336.
Massanyi, P., Tataruch, F., Slamecka, J., Toman, R. and Jurcik, R.(2003). Accumulation of lead, cadmium, and mercury in liver and kidney of the brown hare (Lepus europaeus) in relation to the season, age, and sex in the West Slovakian Lowland, J.Environ. Sci. Health, A39: 1299-1309.
Mahtap Kocak and Ethem Akcil (2006). The effects of chronic cadmium toxicity on the hemostatic system, Pathophysiol Haemost Thromb, 35: 411-416.
Moniusko-Jakoniuk, J. and Brzoska, M.M. (1999). Environment pollution and Health, lek Wojsk, 75(7-8): 419-426.
Nad, P., Massanyi, P., Skalicka, M., Korenekova, B. and Cigankova, V. (2005). The effect of cadmium in combination with Zinc and selenium on ovarian structure in Japanese quails, Rizilove factory Potravoveho Refazca, V: 241-247.
Nordberg, G.F., Bigawam, K., Nordberg, M. and Friedmann, J.M. (2007). Cadmium. In: Hand book on the toxicology of Metals, (Nordberg GF, Fowler BA, Nordberg M, Friberg L, eds). Amsterdam: Elsevier, 445-486.
Ognjanovic, B.I., Markovic, S.D., Pavlovic, S.Z., Zikic, R.V., Stajn, A.S. and Saicic, Z.S. (2008). Effect of Chronic Cadmium exposure on Antioxidant defense system in some tissues of rats: Protective effect of Selenium, Physiol. Res., 57: 403-411.
Ognjanovic, B.I., Pavlovic,S.Z., Maletic,S.D., Zikic, R.V., Stajn, A.S., Radojicic R.M., Saicic, Z.S. and Petrovic,V.M.(2003). Protective influence of Vitamin E on Antioxidant Defence system in the blood of rats treated with Cadmium, Physiol. Res., 52: 563-570.
Petering, H.G., Murthy, L. and Cerklewski, F.L. (1977). Role of nutrition in heavy metal toxicity. In: Biochemical Effects on Environmental Pollutants (Lee SD ed). Ann Arbor, MI: Science Publishers.
Rodriguez-Matas, M.C., Lisboma, F., Gomez-Ayala, A.E., Lopez-Aliaga, I. and Campos, M.S. (1998). Influence of nutritional iron deficiency development on some aspects of iron, copper and zinc metabolism, Laboratory Animals Ltd. Laboratory Animals, 32: 298-306.
Salem Amara, Hafedh Abdelmelek, Catherine Garrel, Pascale Guirud, Thierry Douki, Jean-Luc Ravant, Alian Favier, Mohsen Sakly and Khemais Ben Rhouma (2008). Preventive effect of Zinc Against Cadmium-induced oxidative stress in the rat testis, Journal of Reproduction and Development, 54(2): 129-134.
Saric, M.M., Blanusa, M., Piasek, M., Varnai, V.M., Juresa, D. and Kostial, K. (2002). Effect of dietary cadmium on cadmium absorption and retention in suckling rats, Biometals, 15(2): 175-182.
Schumann, K., Friebel, P., Schmolke, G., Elsenhans, B.(1996). State of iron repletion and cadmium exposure. Arch. Environ. Contam. Toxicol., 31(4): 483-487.
Shuenn-Jiun Yiin, Chi-Liang Chern, Jenn-Yuan Sheu and Te-Hsien Lin. (1999). Cadmium induced lipid peroxidation in rat testes and protection by Selenium, BioMetals, 12, 353–359.
Shibutani, Makoto, Kunitoshi Mitsumori, Shin-ichi Satoh, Hideaki Hiratsuka, Masahiko Satoh, Masami Sumiyoshi, MotohiroNishijima, Yasutaka Katsuki, Jin Sujuki, Jun-ichi Nkagawa, Takumi Akagi, Takayoshi Imazawa and Masanori Ando (2001). Relationship between toxicity and cadmium accumulation rats given low amounts of Cadmium chloride or cadmium – polluted rice for 22 months, The Journal of Toxicological Sciences, 26(5): 337-358.
Siraj Basha, P. and Usha Rani, A. (2003). Cadmium induced antioxidant defense mechanism in fresh water teleost Oreochromls mossambicus (Tilapia), Ecotoxicol. Environ. Safety, 56: 218-221.
Tim S. Nawrot, Etienne Van Hecke, Lutgarde Thijs, Tom Richert, Tatiana Kuznestsova, Yu Jin, Jaco Vangronsveld, Harry A Roels and Jan A. Staessen (2008). Cadmium- Related mortality and long-Term Secular Trends in the Cadmium body burden of an Environmentally Exposed Population,Environmental Health Perspectives, 116(12): 1620-1628.
Trzcinka-ochocka, M., Zakubowski, M., Razniewska, G., Halatek, T. and Gazewaski, A. (2004). The effects of environmental Cadmium exposure on kidney function: the possible influence of age, Env. Res., 95: 143-150.
Usha Rani, A. (2000). Cadmium induced bioaccumulation in the tissues of fresh water teleost Oreochromis mossambicus., The Annals. N. Y. Acad. Sci., 919(1): 318 – 320.
Vahter, M., Berglund, M., Nermell, B. and Akesson, A.(1996). Bioavailability of cadmium from shellfish and mixed diet in women, Toxicol. Appl. Pharmacol., 136: 332-341.
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Effect of combinations of four trace elements on cadmium bioaccumulation in a few tissues of male albino rats. (2010). Journal of Applied and Natural Science, 2(1), 66-69. https://doi.org/10.31018/jans.v2i1.97
