An attempt has been made to find out effectiveness of scorbutogenic diet in albino rats, Rattus norvegicus. These animals received 50 and 80 gm cakes of scorbutogenic diet for 15 and 30 days respectively. No scurvy like symptoms were observed rather boils got appeared on their hind limbs, below ear and neck region. Steroid producing glands indicated enhanced steroidogenesis as evidenced by decreased concentrations of adrenal ascorbate and cholesterol. The results suggested that scorbutogenic diet was ineffective to cause scurvy in this species.
Scurvy, Ascorbate, Steroidogenesis, Mammal
Barnes, M. J., Constable, B. J., Impey, S.G. and Kodicek, E. (1973). Mortality rate in male and female Guinea pigs on scorbutogenic diet. Nature, 242: 522-523.
Bjorkhem, I., Kallner, A and Karlmar, K. E. (1978). Effects of ascorbic acid deficiency on adrenal mitochondrial hydroxylations in guinea pigs. Journal of lipid research, 19: 695-704.
Brake, J.T. (1988). Stress of birds, modern poultry management relationship defined. Poultry Digest May 226-231.
Carson, D.D., Tang, J. P. and Gay, S.(1988). Collagens support embryo attachment and out growth in vitro: Effects of the Arg-Gly-Asp sequence. Developmental Biology, 127: 368-375.
Chinoy, N. J., Mehta, R.R., Seetilalakhmi, L., Sharma, J. D. and Chinoy, M. R.(1986). Effects of vitamin C deficiency on physiology of male reproductive organs of guinea pigs. International Journal of Fertility, 31: 232-239.
Clayman, M., Tsung, D., Nicola, A. F. and Jhon-Stone, R. M. (1970). Specificity of action of adrenocorticotropin in vitro on ascorbate transport in rat adrenal gland. Biochem. J. , 118: 283-289.
Clow, C. L., Laberce, C and Scriver, C. R.(1975). Neonatal hypertyrosinema and evidence for deficiency of ascorbic acid in artic and sub artic peoples. Canadian Medical Association Journal, 113: 624-626.
Dabrowaski, K., Hinterleitner, S., Stunnbaoer, C and Fiky, E.I.N. (1988). Application of a simultaneous assay of ascorbic acid, dehydroascorbic acid and ascorbic sulphate in biological materials. Aquaculture,, 72: 295.
Debora, M.F., Mary, E.A., Donald, K. N. and Olav, T.O. (1998). Oscars, Astronotus ocellatus. Have a dietry requirement for vitamin C. Journal of Nutrition, 128: 1745-1751.
Elster, S.K. (1950). Effects of ascorbic acid deficiency on collagen content of guinea pig tissues. Am. J. Physiol, 161:283.
Fazleabas, A.T., Bell, S.C., Fleming, S., Sun, J and Lessey, B.A. (1997). Distribution of integrins and the extracellular matrix proteins in the baboon endometrium during the menstrual cycle and early pregnancy. Biology of Reproduction, 56: 348-356.
Gerardo, R.C., Allekotle, R. and Kravetz, F.O. (2000).Scurvy in capybaras breed in captivity in Argentine. Journal of Wild life Disease, 36 (1): 97-101.
Jackel, S.S., Mosbach, E.H., Burns, J.J and King, C.G. (1950). The synthesis of L-ascorbic acid by the albino rat. American Chemical Society in Philadelphia [c.f. Jackel et al.(1950) Department of chemistry, Columbia University, New York]
Jones, P.R., Hurley, R.J. and Hughes, R.E.(1973). Dietary cholesterol sex and scurvy in guinea pigs. Nature, 242: 521-522.
Kharb, S. (2000). Total free radical trapping antioxidamt potential in pre-eclampsia. Int. J. Gynaecol. Obset., 69:23-26.
Kipp,D.E., Mc Elvin, M., Kimmel, D.B., Akhtar, M.P., Robinson, R.G. and Lukert, B.P.(1996). Scurvy results in decreased collagen synthesis and bone density in guinea pig animal model. Bone, 18: 281-288.
Nockles, C.F. (1990). Vitamin needs increase during stress, disease. Poultry Digest, May. 218-226.
Odumosu, A and Wilson, C.W. (1973). Metabolic availability of vitamin C in the guinea pigs. International Journal of Fertility, 31: 232-239.
Roy, R.K., Banerjee, S.K., Majumdar, P. K., Sasmal, N and Chatterjee, G.C. (1973). Effects of manganese, cobalt and molybdenum on ascorbic acid metabolism and other related pathways in control and ascorbic acid deficient guinea pigs. Indian Journal of Biochemistry and Biophysics, 10: 202-205.[ c.f. Hegsted, D.M., Mills, R.C., Elvehjem, C.A. and Hart, E.B.(1941). J.Biol.Chem., 138: 459].
Sherman, M. I., Gay, R. and Miller, E.J.(1980). Association of collagen with preimplantation and peri-implantation mouse embryos. Developmental Biology, 74: 470-478.
Simon, J.A. and Hudes, E.S. (2000) Serum antioxidants and gallbladder disease prevalence among US adults. Arch. Intern. Med., 160: 931-936.
Train, J.J. and Trounson, A.O. (1993). Effects of stimulation or inhibition of lipid peroxidation on freezing thawing of mouse embryos. Biology of Reproduction, 49: 1362-1368.
Valkonen, M.M. and Kuusi.T. (2000). Vitamin C prevents the acute atherogenic effects of passive smooking. Free Radic. Biol. Med., Feb1, 28: 428-436.
Washburn, K.W. and Nix, D.F. (1974). A rapid technique for the extraction of yolk cholesterol. Poult. Sci., 53: 1118-1122.
Wilkinson, I.B., Megson, I.L. and MacCallum H. (1999). Oral vitamin C reduces arterial stiffnes and platelet aggregation in humans. Journal Cardiovasc Pharmacol., 34: 690-693.
Zollinger, P.E., Tuinebreijer, W.E., Kreis, R.W. and Breederveld, R.S. (1999). Effect of Vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet, 354: 2025-2028.
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