Pattern of lipid fractions in plasma and cardiovascular tissues under Cryptorchidism in albino rat
Article Main
Abstract
Bilateral cryptorchidism was induced surgically in adult wistar strain male albino rats and lipid fractions such as total lipids, total cholesterol, Free cholesterol, Esterified cholesterol, phospholipids, Triglycerides and free fatty acids were analysed in the plasma, heart and dorsal aorta. The lipid fractions such as triglycerides (56.63%), free (20.82%) and esterified (61.25%) cholesterol as well as fatty acids in glycerol (64.42%) had significant elevation in the plasma of cryptorchid animals. Similarly LDL lipid fractions (64.99%) were also elevated markedly under
cryptorchid conditions which are the markers of the obesity and atherosclerosis. The lipid fractions such as triglycerides (50.47%, 48.17%), cholesterol (74.64%, 67.7%) and phospholipids (42.04%, 68.88%) showed significant elevations in the heart and dorsal aorta of the cryptorchid animals over the control. The heart, dorsal aorta and plasma had significant accumulation of triglycerides and cholesterol fractions, suggesting the possible deposition of lipid fractions in the tissues, which can be attributed to the possible suppression in the mobilization of lipid fractions into energy metabolism. Such an accumulation of lipid fractions under cryptorchid condition can be considered as the development of risk factor for the cardio-vascular disorders.
Article Details
Article Details
Cryptorchidism, Albino rat, Lipid fractions, Cardiovascular, Tissues-Plasma
Chase, M.P., I.I. Geschwind and H.A. Bern (1957). Synergistic role of prolactin in response to male rat sex accessories to androgen. Proc.Soc.Exp.Biol.Med., 94: 680-683.
Demura, R., Suzuki, T., Nakamura, S., Komatsu, H., Jibiki, K., Odagiri, E., Demura, H.and Shizume, K. (1987). Effect of uni and bilateral cryptorchidism on testicular inhibin and testosterone secretion in rats. Endocrinol Jpn., Dec 34(6); 911-7.
Farooqui, S.M., Al-Bagdadi, F.O., Donnell, J.M. and Stont,R. (1997). Degenerative changes in spermatogonare associated with loss of glucose transporter (Glut 3) in abdominal testis of surgically induced unitaferal cryptorchidism in rats. Biochem.Biophys.Res.Commun.,236 (2): 407-12.
Folch, J.M., Lees, M.P. and Stane-stanley, G.H. (1969). A simple method for the isolation and purification of total lipids from animal tissues. J.Biol. Chem., 226: 497.
Friedewald, W.T., Levy, R.I. and Fredrickson, D.S. (1972). Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem., 18(6): 499-502.
Friedman, R.M., Lopez, F.J., Tucker, J.A., King, L.R. and Nigrovillar, A. (1994). Fertility after cryptorchidsm; a comparative analysis of early orchidopexy with and without concomitant hormonal therapy in the young male rat. J.Urol. Jan., 15(1): 227-35.
Galan, Francisco, Maria soledad Agerilar, Juan Gonzalez, Fernando celmente, Rafael sanchez, Marmel Topia and Manuel Moya. (1991). Interstitial 15q deletion without a classic praderwilli phenotype. Am.J.Med.Genet. ,38(4); 532-534.
Main, S.J. and Waites, G.M.H. (1997). The blood-testis barrier and temperature damage to the testis of rat. J.Reprod. Fertil., 51: 439-450.
Malyshkin, (1997). In; the interaction of changes in the genitilia in the pathogenesis of sterility in men. Lik sprava, May- June (3) 83-7.
Morimoto, Shinji, Yoshikazu Haisa, Toshihiro maeda, Michinori Harada, Tasuya wada, Tsukasa, Aihara, Masaaki Band, Yoshihiro Nakai, Yoshihiro Kataoka and Hiroyoshi Mori. (1986). Relation of serum apolipoprotein and lipoprotein and coronary atherosclerosis. Respir. Cire., 134 (1): 1221-1226.
Natelson, S. (1971a). Total cholesterol procedure Lieberamann – Burchard reagent. In: Techniques of clinical chemistry. Charles C. Thomas publishers, spring field USA, Illinois, 3rd edn. 263.
Natelson, S. (1971b). Free fatty acids in serum. In: Techniques of clinical chemistry, charles c. Thomas publishers, Spring field USA Illinois, 3rd edn., p-477-481.
Natelson, S. (1971c). Triglycerides In: Techniques of clinical chemistry charles C- Thomas publishers, Spring field. USA 3rd edn. Illinois. P 720-723.
Nossen, J.O., Rustan, A.C., Bjørneboe, G.E., Bjørneboe, A., Drevon, C.A. (1986). Lipoproteins and arteriosclerosis. From cell biology to environmental factors. Tidsskr Nor Laegeforen. Oct 30; 106(30):2495-9.
Pereira O.C., Picarelli, Z.P., Abreu L.C. (1993). “Experimental cryptorchidism in pre-pubertal rats; some effects on reactivity of the seminal vesicle to catecholamines”. Pharmacol. Res. Sep., 28(2): 175-81.
Rijli, Filippo, M, Robert Matyas, Massimo pellegrini, Andree Dierich, Peter Gruss, pascal Dolle and Pierre chambon. (1995). Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa – 10 mutant mice. Proceedings of the National Academy of Sciences of the united states of America., 92 (18): 8185-8189.
Shizume, K. (1987). Effect of uni and bilateral cryptorchidism on testicular inhibin and testosterone secretion in rats. Endocrinol Jpn. Dec. 34 (6):91 1-7.
Veracrug, N.C., Gomes W.R., and VanDemark, N.L. (1970). The effect of steroid and gonadotrophic hormones invitro on the metabolic activity of normal and cryptorchid rat testicular tissues. Biol. Reprod., 2: 376.
Wu, N. and Murono, E.P.(1996). Temperature and germ cell regulation of Leydig cell proliferation stimulated by sertoli cell-secreted mitogenic factor, a possible role in cryptorchidism. Andrologia, Sept-Oct; 28 (5): 247-57.
Zipt, W.B., Payne, A.H. and Kelch, R.P. (1978). Prolactin growth hormone and luetinizing hormone in the maintenance of testicular luteinizing hormone receptors. Endocrinol., 103: 595-599.
This work is licensed under Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) © Author (s)
