Cadmium induced histopathological changes in the stomach and small intestine of Swiss albino mice Mus musculus
Article Main
Abstract
The results on the effect of oral administration of cadmium chloride on the histomorphology of the stomach and small intestine of Swiss albino mice revealed severe histopathological effects in the tissues of both stomach and small intestine. There is marked atrophy of musculature, and disintegration of sub-mucosal and mucosal tissues, distortion of villi with disintegration of mucosal epithelial cells characterized by cytoplasmic vacuolization, nuclear pycnosis and nuclear fragmentation. A significant damage in the Brunner’s gland and crypts of Liberkuhn has been observed.
Article Details
Article Details
Keywords
Cadmium chloride, Serosa, Musculature, Brunner’s glands, Crypts of liberkuhn
References
Babu, S. M., Venu Gopal, N. and Pratap R. K. (2007). Post natal antioxidant enzyme activity of rat brain regions during developmental lead exposure. J. Environ. Biol., 28, 21-27.
Bataineh, H., Al-Hamood, M. and Elbetieha, A. (1998). Assessment of aggression, sexual behaviour and fertility in adult male rat following long-term ingestion of four industrial metal salts. J. Human Exp. Toxicol., 17: 570-576.
Bu-Olayan, A. H., Al-Hassan, R., Thomas, B. V. and Subhrmanyam, M.N.V. (2001). Impact of trace metal sand nutrient levels on phytoplanktons from the Kuwait coast. Environ. Int., 26: 199-203.
Cotte-Krief. M.C., Guiea, C., Thomas, A. J. and Martin, J. M. (2000). Sources of Cd, Cu, Ni and Zn in Portuguese coastal waters. Mar. Chem., 71: 199-214.
Doreswamy, K., Balakrishna, S., Thimappa, R. and Muralidhara, K. (2004). Nickel induced oxidative stress in testis of mice: Evidence of DNA damage and genotoxic effects. Journal of Andrology, 25 (6) November/December 2004.
Elbetieha, A., Al-Hamood, M. (1997). Term exposure of male and female mice to trivalent and hexavalent chromium compounds. Effect on fertility. J. toxicol., 116: 39-47.
Esser, B. K. and Volpe, A. (2002). At sea high-resolution trace element mapping: San Diego bay and its plume in adjacent coastal ocean. Environ. Sci. Technol., 36: 2826-32.
Garba, S. H., Adelaiye, A. B. and Mshelia, L.Y. (2007). Toxicological Effects of Inhaled Mosquito Coil Smoke on the Rat Spleen: A Hematological and Histological study. J. Med. Sci., 7 (1): 94-99.
Gurer Orhan, H. and Ercal, N. (2000). Can antioxidants beneficial in the treatment of lead poising. Free radical Biol. Med., 29, 927-945.
Karmakar, R., Bhattacharya, R. and Chatterjee, M. (2000) Biochemical, hematological and histopathological study in relation to time-related cadmium induced hepatotoxicity in mice. Biometals, 13 (3): 231-239.
Kennish, M. J. (1996). Practical Handbook of Estuarine and Marine Pollution. CRC Press, New York, 535pp.
Kwon K. S., Cho, K. J. and Yang, E. J. (1997). The study of anatomical and biochemical effects of cadmium on the testis in rats. Dev. Reprod., 1: 125-132.
Macfarlane, G. R. and Burchett, M. D. (2001). Photosynthetic pigments and peroxidase activity as indicators of heavy metal stress in the grey mangrove, Avicennia marina (Forsk). Viesh. Mar. Pollut. Bull., 42: 233-40.
Mayyas, I., Elbetieha, A., Khamas, W. and Khamas, W. A. (2005). Evaluation of reproductive and fertility toxic potentials of aluminium chloride on adult male mice. J. Anim. Vet. Adv., 4: 224-233.
McDowell, L.S. (1992). Minerals in Animal and human nutrition. Academic Press Inc. California, 361-364.
Phetsombat, S., Maleeya, K., Pokethitiyook, P. and Upatham, S. (2006). Toxicity and bioaccumulation of cadmium and lead in Salvinia cucullata. L. J. Environ. Biol., 27, 645-652.
Rebhun, S. and Amotz, A. B. (1984). The distribution of cadmium between the marine algae Chlorella stigmatophora and sea water medium. Water Res., 18: 173-178.
Robbins, S. and Angell, D. (1976). Basic Pathology, 2ndEd, W. B. Saunders Company, Philadelphia, London.
Saksena, S. and Lau, I. (1979). Effects of cadmium chloride on testicular steroidogenesis and fertility of male rats. J. Endocrinol., 74: 6-12.
Sharma, G. P., Sareen, M. L. and Monga, V. K. (1980). Effect of cadmium chloride on the testis of the Guinea pig, Cavia cobaya. Proc. Nat. Agad. Sci. India, 50 (B), III.
Wickfors, G. H. and Ukeles, R. (1982). Growth and adaptation of estuarine unicellular algae in media with excess copper, cadmium and zinc. Mar. Ecol. Progr. Ser., 191-206.
Yang. H. S., Dong Kein, H., Jung Ran, K. and Jae Chul Sim (2006). Effects of a-tocopherol on cadmium induced toxicity in rat testis and spermatogenesis. Journal of Korean Medical Science. 21 (3) 445-451.
Zhang, L.Y. and Wang, C.X. (1984). Histopathological and histochemical studies on toxic effect of brodifacoum in mouse liver. Acta Acad Med Sci., 6 (5) :386-388.
Bataineh, H., Al-Hamood, M. and Elbetieha, A. (1998). Assessment of aggression, sexual behaviour and fertility in adult male rat following long-term ingestion of four industrial metal salts. J. Human Exp. Toxicol., 17: 570-576.
Bu-Olayan, A. H., Al-Hassan, R., Thomas, B. V. and Subhrmanyam, M.N.V. (2001). Impact of trace metal sand nutrient levels on phytoplanktons from the Kuwait coast. Environ. Int., 26: 199-203.
Cotte-Krief. M.C., Guiea, C., Thomas, A. J. and Martin, J. M. (2000). Sources of Cd, Cu, Ni and Zn in Portuguese coastal waters. Mar. Chem., 71: 199-214.
Doreswamy, K., Balakrishna, S., Thimappa, R. and Muralidhara, K. (2004). Nickel induced oxidative stress in testis of mice: Evidence of DNA damage and genotoxic effects. Journal of Andrology, 25 (6) November/December 2004.
Elbetieha, A., Al-Hamood, M. (1997). Term exposure of male and female mice to trivalent and hexavalent chromium compounds. Effect on fertility. J. toxicol., 116: 39-47.
Esser, B. K. and Volpe, A. (2002). At sea high-resolution trace element mapping: San Diego bay and its plume in adjacent coastal ocean. Environ. Sci. Technol., 36: 2826-32.
Garba, S. H., Adelaiye, A. B. and Mshelia, L.Y. (2007). Toxicological Effects of Inhaled Mosquito Coil Smoke on the Rat Spleen: A Hematological and Histological study. J. Med. Sci., 7 (1): 94-99.
Gurer Orhan, H. and Ercal, N. (2000). Can antioxidants beneficial in the treatment of lead poising. Free radical Biol. Med., 29, 927-945.
Karmakar, R., Bhattacharya, R. and Chatterjee, M. (2000) Biochemical, hematological and histopathological study in relation to time-related cadmium induced hepatotoxicity in mice. Biometals, 13 (3): 231-239.
Kennish, M. J. (1996). Practical Handbook of Estuarine and Marine Pollution. CRC Press, New York, 535pp.
Kwon K. S., Cho, K. J. and Yang, E. J. (1997). The study of anatomical and biochemical effects of cadmium on the testis in rats. Dev. Reprod., 1: 125-132.
Macfarlane, G. R. and Burchett, M. D. (2001). Photosynthetic pigments and peroxidase activity as indicators of heavy metal stress in the grey mangrove, Avicennia marina (Forsk). Viesh. Mar. Pollut. Bull., 42: 233-40.
Mayyas, I., Elbetieha, A., Khamas, W. and Khamas, W. A. (2005). Evaluation of reproductive and fertility toxic potentials of aluminium chloride on adult male mice. J. Anim. Vet. Adv., 4: 224-233.
McDowell, L.S. (1992). Minerals in Animal and human nutrition. Academic Press Inc. California, 361-364.
Phetsombat, S., Maleeya, K., Pokethitiyook, P. and Upatham, S. (2006). Toxicity and bioaccumulation of cadmium and lead in Salvinia cucullata. L. J. Environ. Biol., 27, 645-652.
Rebhun, S. and Amotz, A. B. (1984). The distribution of cadmium between the marine algae Chlorella stigmatophora and sea water medium. Water Res., 18: 173-178.
Robbins, S. and Angell, D. (1976). Basic Pathology, 2ndEd, W. B. Saunders Company, Philadelphia, London.
Saksena, S. and Lau, I. (1979). Effects of cadmium chloride on testicular steroidogenesis and fertility of male rats. J. Endocrinol., 74: 6-12.
Sharma, G. P., Sareen, M. L. and Monga, V. K. (1980). Effect of cadmium chloride on the testis of the Guinea pig, Cavia cobaya. Proc. Nat. Agad. Sci. India, 50 (B), III.
Wickfors, G. H. and Ukeles, R. (1982). Growth and adaptation of estuarine unicellular algae in media with excess copper, cadmium and zinc. Mar. Ecol. Progr. Ser., 191-206.
Yang. H. S., Dong Kein, H., Jung Ran, K. and Jae Chul Sim (2006). Effects of a-tocopherol on cadmium induced toxicity in rat testis and spermatogenesis. Journal of Korean Medical Science. 21 (3) 445-451.
Zhang, L.Y. and Wang, C.X. (1984). Histopathological and histochemical studies on toxic effect of brodifacoum in mouse liver. Acta Acad Med Sci., 6 (5) :386-388.
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Cadmium induced histopathological changes in the stomach and small intestine of Swiss albino mice Mus musculus. (2009). Journal of Applied and Natural Science, 1(2), 253-257. https://doi.org/10.31018/jans.v1i2.66
