Correlation of (IL-10) gene rs 1800896 polymorphism and tuberculosis risk in Iraq's Nineveh city
Article Main
Abstract
The equilibrium between host immune factors and bacterial evasion methods is critical for tuberculosis (TB) control. One immunomodulatory factor that has been suggested to affect a person's vulnerability to tuberculosis is interleukin-10 (IL-10).The study aimed to Identify: (1) Association of (IL-10) gene rs 1800896 polymorphism and the hazard of TB infection, (2) a novel variation of this gene that may be influencing its activity, (3) Association of some haematology tests and tuberculosis. The study included 334 patients with tuberculosis and control. DNA was extracted from blood samples, (IL-10) gene rs 180096 polymorphism was detected by Tetra ARMS PCR and gene sequencing method. (IL-10) levels were detected by Elisa test. Sequencing results for amplifying of the (IL-10) gene in tuberculosis patients revealed the existence of several nucleotide sequence variations that have not been reported before. Both a new phenotype of the (IL-10) protein and a new genotype for the (IL-10) gene were discovered in Nineveh, Iraq, at the National Center for Biotechnology Information. The ARMS PCR reaction results indicated a correlation between the genomic variation of the (IL-10) gene at the site (rs 180096) and tuberculosis patients. The genetic variation was observed in three different genotypes with varying proportions. The native allele C had a higher allelic frequency (65%) than the mutant allele T (35%). The study concluded that individuals with the (IL-10) gene rs180096 TT genotype under the dominant model were more likely to be at risk of TB infection.
Article Details
Article Details
Keywords
IL10, Immune genes, Mycobacterium tuberculosis, Polymorphism, Tuberculosis
References
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Algawwam, H. G. W. & Hasan, A. E. (2024). "Impact of Genetic Polymorphism on Pulmonary Function and Individualized Treatment Plan in Pulmonary Tuberculosis," Hilla University College Journal For Medical Science, (2), 2, Article 2. https://doi.org/10.62445/2958-4515.1018
Ali, Z. A., Mankhi A. A. & Ad’hiah, A. H. (2022). Interleukin-37 gene polymorphism and susceptibility to pulmonary tuberculosis among Iraqi patients. Indian J Tuberc, 69(2), 191– 200. https://doi.org/10.1016/j.ijtb.2021.08.003
Aljanaby, A. A., Al-Faham Q. M. H., Aljanaby, I. A. J. & Hasan, T. H. (2022). Epidemiological study of Mycobacterium Tuberculosis in Baghdad Governorate, Iraq. Gene Reports. 26 (3), 101467. https://doi.org/10.1016/j.genrep.2021.101467
Al–Tamimi, B. J., Al-Mayah, Q. S. & Abd-Alwahab, H. S. (2022). Study of HLA-G gene polymorphism and serum level of soluble HLAG in patients infected with Mycobacterium tuberculosis. Revis Bionatura, 7(3), 24. https://doi.org/10.21931/RB/2022.07.03.24
Ameen, N.Y., Abed, M.Q., Utba, N. M. & Mankhi, A. A. (2018). Genetic polymorphisms of IL-17A in association with the risk of pulmonary tuberculosis in Iraqi patients. Asian J Pharm Clin Res. 11(10), 428–432. https://doi.org/10.22159/ajpcr.2018.v11i10.26008.
Anggraini, D., Nasrul, E., Susanti, R. & Suharti, N. (2023). Polymorphysm of tumor necrosis factor-Α interleukin-10 gene with pulmonary tuberculosis susceptibility. Journal of Population Therapeutics and Clinical Pharmacology, 30(2), 50–58. https://doi.org/10.47750/jptcp.2023.1064
Aravindan, P.P. (2019). Host genetics and tuberculosis: Theory of genetic polymorphism and tuberculosis. Lung Indi, 36(3), 244-252. https://doi.org/10.4103/lungindia.lungindia_146_15.
Areeshi, M. Y., Mandal, R. K., Dar, S. A., Jawed, A., Wahid, M., Lohani, M. Panda, A.K., Mishra, B.N., Akhter, N. & Haque, S. (2017). IL-10 -1082 A>G (rs1800896) polymorphism confers susceptibility to pulmonary tuberculosis in Caucasians but not in Asians and Africans: a meta-analysis. Bioscience Reports, 37(5), BSR20170240. https://doi.org/10.1042/BSR20170240.
Carabalí-Isajar, M. L., Rodríguez-Bejarano, O. H., Amado, T., Patarroyo, M. A., Izquierdo, M. A., Lutz, J. R. & Ocampo, M. (2023). Clinical manifestations and immune response to tuberculosis. World J Microbiol Biotechnol. 39(8), 206. https://doi.org/10.1007/s11274-023-03636-x.
De Martino, M., Lodi, L., Galli L. & Chiappini, E. (2019). Immune Response to Mycobacterium tuberculosis: A Narrative Review. Front Pediatr, 27, 7, 350. https://doi.org/10.3389/fped.2019.00350.
Ferreira, C. M., Barbosa, A. M., Barreira-Silva, P., Silvestre, R., Cunha, C., Carvalho, A. Rodrigues, F., Correia-Neves, M., Castro, A. G. & Torrado, E. (2021). Early IL-10 promotes vasculature-associated CD4+ T cells unable to control Mycobacterium tuberculosis infection. JCI Insight, 6(21), e150060. https://doi.org/10.1172/jci.insight.150060.
Gao, L., Xiong, Y. J., Liang, Y. X., Huang, P. F., Liu, S., Xiao, Y., Huang, Q., Wang, H. & Wu, H. M. (2024). The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis. Front Immunol, 16,15:1267624. https://doi.org/10.3389/fimmu.2024.1267624.
Gao, X., Chen, J., Tong, Z., Yang, G., Yao, Y., Xu, F. & Zhou, J. (2015). Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Tuberculosis: A Meta-Analysis. PLoS ONE, 10(6), e0127496. https://doi.org/10.1371/journal.pone.0127496
García-Elorriaga, G., Vera-Ramírez, L., del Rey-Pineda, G. & González-Bonilla, C. (2013). -592 and -1082 interleukin-10 polymorphisms in pulmonary tuberculosis with type 2 diabetes. Asian Pacific Journal of Tropical Medicine, 6(7), 505-509. https://doi.org/10.1016/S1995-7645(13)60086-3
Harishankar, M., Selvaraj, P. & Bethunaickan, R. (2018). Influence of Genetic Polymorphism Towards Pulmonary Tuberculosis Susceptibility. Front Med (Lausanne), 5, 213. https://doi.org/10.3389/fmed.2018.00213.
He, S., Yang, S., Zhao, Q., Wang, L., Liu, H., Sheng, Y. Yuan, D. & Jin, T. (2018) . Association of IL4, IL6, and IL10 polymorphisms with pulmonary tuberculosis in a Tibetan Chinese population. Oncotarget, 9(23), 16418-16426. https://doi.org/10.18632/oncotarget.23995.
Hu, Y., Wu, L., Li, D., Zhao, Q., Jiang, W. & Xu, B. (2015). Association between cytokine gene polymorphisms and tuberculosis in a Chinese population in Shanghai: a case-control study. BMC Immunology, 16, 8. https://doi.org/10.1186/s12865-015-0071-6.
Ibrahim, M. A. & Faisal, R. M. (2024). Molecular characterization of antibiotic resistance and virulence genes on plasmids of Proteus mirabilis isolated from urine samples of Hospitals in Mosul City, Iraq. Journal of Applied and Natural Science, 16(2), 830-841. DOI: https://doi.org/10.31018/jans.v16i2.5526.
Iyer, S. S. & Cheng ,G. (2012). Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Critical Reviews in Immunology, 32(1), 23-63. https://doi.org/10.1615/critrevimmunol.v32.i1.30.
Kang, Y. J., Park, H., Park, S. B., Kim, J., Lee, J., Kim, J., Park, S., Lee, Y. S. & Kim, S. (2021). Combined analysis of whole blood interferon gamma release assay and complete blood count analysis for rapid discrimination of active tuberculosis and latent tuberculosis infection. Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 24, 100253. https://doi.org/10.1016/j.jctube.2021.100253.
Liu, Q., Chen, X. & Dai, X. (2022). The association of cytokine gene polymorphisms with tuberculosis susceptibility in several regional populations. Cytokine, 156,155915. https://doi.org/10.1016/j.cyto.2022.155915.
Liu, Q., Li, W., Li, D., Feng, Y. & Tao, C. (2015). The association of interleukin-10 -1082, -819, -592 polymorphisms and tuberculosis risk. Saudi medical journal, 36(4), 407-17. https://doi.org/10.15537/smj.2015.4.10545.
Ma, J., Lv, Z., Wang, J. & Lu , J. (2019). Relationship Between IL-10 Gene Polymorphism and Spinal Tuberculosis. Medical Science Monitor, 25:4901-4906. https://doi.org/10.12659/MSM.914039.
Moghaddam, S. G. M., Namaei, M. H., Manoochehri, R. E. & Zardast, M. (2020). The sequential assay of interleukin-10 and 13 serum levels in relation to radiographic changes during pulmonary tuberculosis treatment. Journal of Research in Medical Sciences, 25(1), 63. https://doi.org/10.4103/jrms.JRMS_116_19.
Naim, N. (2019). Result Analysis of Erythrocyte Sedimentation Rate (ESR) For Tuberculosis (TB) Patient with AntiTuberculosis Drug. International Journal of Science and Healthcare Research, 4(2) : 143-148 www.ijsh r.com.
Namaei, M. H., Mortazavi-Moghaddam, S. G., Eslami-Manoochehri, R. & Zardast, E. M. (2019). The role of Interleukin-10 and 13 in tuberculosis-associated pulmonary dysfunction. Caspian Journal of Internal Medicine, 10(2), 223-227. https://doi.org/10.22088/cjim.10.2.223.
Rohini, K., Surekha Bhat, M., Srikumar, P. S. & Mahesh Kumar, A. (2016). Assessment of Hematological Parameters in Pulmonary Tuberculosis Patients. Indian Journal of Clinical Biochemistry, 31(3), 332-5. https://doi.org/10.1007/s12291-015-0535-8.
Saati, A. A., Khurram, M., Faidah, H., Haseeb, A. & Iriti, M. (2021). A Saudi Arabian Public Health Perspective of Tuberculosis. International Journal of Environmental Research and Public Health, 18, 10042. https://doi.org/10.3390/ijerph181910042
Salman, M. S., Issa, A. H. & Humoud, M. N. (2017). Molecular Study of two Types of Mutations in Promoters of IL-2 and IL-10 Genes in Iraqi Patients with Tuberculosis. Donnish Journal of Genetics and Molecular Biology, 2(1) pp. 001-004. http://www.donnishjournals.org/djgmb.
Saripalli, A. & Ramapuram, J. (2022). C-Reactive Protein as a Screening Test for Tuberculosis in People Living with HIV in Southern India: A Cross-Sectional, Observational Study. Journal of Clinical Medicine, 11(13), 3566. https://doi.org/10.3390/jcm11133566.
Scriba, T. J., Coussens, A. K. & Fletcher, H. A.( 2017). Human Immunology of Tuberculosis. Microbiol Spectrum, 5(1).TBTB2- 0016-2016. https://doi.org/10.1128/microbiolspec.tbtb2-0016-2016.
Shermeh, A. S., Khoshmirsafa, M., Delbandi, A., Tabarsi, P., Mortaze, E., Bolouri, M. R., Fayeze, E. A., Seif, F. & Shekarabi, M. (2020). IL-10-592 A/C Gene Polymorphism and Cytokine Levels are Associated with Susceptibility to Drug Resistance in Tuberculosis. Turkish Journal of Immunology, 8(3), 103–112. http://doi.org/10.25002/tji.2020.1235
Stefanescu, S., Cocoș, R., Turcu-Stiolica, A., Shelby, E. S., Matei, M., Subtirelu, M. S. Meca, A.D., Stanciulescu, E.C., Popescu, S.O., Biciusca, V. & Pisoschi, C.G. (2021). Prediction of Treatment Outcome with Inflammatory Biomarkers after 2 Months of Therapy in Pulmonary Tuberculosis Patients: Preliminary Results. Pathogens, 10(7), 789. https://doi.org/10.3390/pathogens10070789.
Sulochana, S., Gayathri, S. J. R. & fathima, J. (2022). Clinical Significance of Erythrocyte Sedimentation Rate in Tuberculosis. Research Journal of Pharmacy and Technology, 15(1), 245-9. https://doi.org/10.52711/0974-360X.2022.00040
Trifunović, J., Miller, L., Debeljak, Ž. & Horvat, V. (2015). Pathologic patterns of interleukin 10 expression--a review. Biochemia Medica (Zagreb), 25(1), 36-48. https://doi.org/10.11613/BM.2015.004.
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Correlation of (IL-10) gene rs 1800896 polymorphism and tuberculosis risk in Iraq’s Nineveh city. (2025). Journal of Applied and Natural Science, 17(2), 486-498. https://doi.org/10.31018/jans.v17i2.6381
