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Garima Bora Abhishek Gunna Megha M. Kumar Sonia Morya Chinaza Godswill Awuchi Farid Menaa

Abstract

Probiotics are live organisms that generally give consumers health advantages by improving or restoring the gut flora. Lactobacillus and Bifidobacterium are the two most commonly known probiotics. They have vital role in the prevention and/or diagnosis of many diseases, such as obesity, cancer, asthma, diarrhoea, hay fever, diabetes, chronic fever, HIV, and atopic eczema. They also help to maintain the gut microflora of the intestine. Gut microbiota reside in the gastrointestinal tract of humans, which can be bacteria, fungi, viruses, or protozoa and bacteriophages, which are essential for maintaining healthy gut health. The most dominant gut microbial phyla consist of firmicutes, actinobacteria, proteobacteria, bacteroidetes, and fusobacteria. In 90% of the gut microbiata belongs to the two important phyla-firmicutes and bacteroidetes. Examples include Lactobacillus acidophilus, Clostridium perfringens, Helicobacter pylori, Bacteroides fragilis, and Corynebacterium matruchotii. This review paper focuses on the role of probiotic microorganisms in preventing certain chronic diseases. The role of gut microbiota in maintaining human health is very crucial. They are known to maintain the host's homeostasis by providing protection against pathogens, training the immune system, better processing dietary compounds, and assisting proper nutrient uptake.


 

Article Details

Article Details

Keywords

Actinobacteria, Bacteroides, Good health, Well-being, Gut microbiota

References
Abenavoli, L., Scarpellini, E., Colica, C., Boccuto, L., Salehi, B., Sharifi-Rad, J., … & Capasso, R. (2019). Gut microbiota and obesity: a role for probiotics. Nutrients, 11(11), 2690.http://dx.doi.org/10.3390/nu11112690
Alesa, D. I., Alshamrani, H. M., Alzahrani, Y. A., Alamssi, D. N., Alzahrani, N. S. & Almohammadi, M. E. (2019). The role of gut microbiome in the pathogenesis of psoriasis and the therapeutic effects of probiotics. Journal of Family Medicine and Primary Care, 8(11), 3496–3503. http://doi.org/10.4103/jfmpc.jfmpc_709_19
Alessandri, G., van Sinderen, D. & Ventura, M. (2021). The genus Bifidobacterium: From genomics to functionality of an important component of the mammalian gut microbiota running title: Bifidobacterial adaptation to and interaction with the host. Computational and Structural Biotechnology Journal, 19, 1472–1487. https://doi.org/10.1016/j.csbj.2021.03.006
Antony, S. & de Leon, M. P. (2018). Probiotics and its relationship with the cardiovascular system. Probiotics Curr. Knowl. Future Prospect, 52–68. http://doi.org/10.5772/intechopen.75077
Ayivi, R. D., Gyawali, R., Krastanov, A., Aljaloud, S. O., Worku, M., Tahergorabi, R., … & Ibrahim, S. A. (2020). Lactic acid bacteria: Food safety and human health applications. Dairy, 1(3), 202-232.;https://doi.org/10.3390/dairy1030015
Azad, M. A. K., Sarker, M., Li, T. & Yin, J. (2018). Probiotic species in the modulation of gut microbiota: An overview. BioMed Research International, 2018, 9478630. http://doi.org/10.1155/2018/9478630
Ballini, A., Charitos, I. A., Cantore, S., Topi, S., Bottalico, L. & Santacroce, L. (2023). About Functional Foods: The Probiotics and Prebiotics State of Art. Antibiotics, 12(4), 635.https://doi.org/10.3390/antibiotics12040635
Bodke, H. & Jogdand, S. (2022). Role of probiotics in human health. Cureus, 14(11). https://doi.org/10.7759/cureus.31313
Bin-Asif, H. & Ali, S. A. (2019). The genus Enterococcus and its associated virulent factors (pp. 109–130). London. http://doi.org/10.5772/intechopen.89083
Cerdó, T., García-Santos, J. A., G. Bermúdez, M. & Campoy, C. (2019). The role of probiotics and prebiotics in the prevention and treatment of obesity. Nutrients, 11(3), 635.https://doi.org/10.3390/nu11030635
Ciprandi, G., & Tosca, M. A. (2022). Probiotics in Allergic Rhinitis Management: Is There a Positioning for Them? Allergies, 2(3), 119–127. https://doi.org/10.3390/allergies2030011
Collado, M. C., Isolauri, E., Salminen, S. & Sanz, Y. (2009). The impact of probiotic on gut health. Current Drug Metabolism, 10(1), 68–78. http://doi.org/10.2174/138920009787048437
Dizzell, S., Nazli, A., Reid, G. & Kaushic, C. (2019). Protective effect of probiotic bacteria and estrogen in preventing HIV-1-mediated impairment of epithelial barrier integrity in female genital tract. Cells, 8(10), 1120. http://doi.org/10.3390/cells8101120
Elshaghabee, F. M. F. (2017). Probiotics food supplement for NAFLD. Journal of Nutritional Health and Food Engineering, 6(4). http://doi.org/10.15406/jnhfe.2017.06.00209
Eslami, M., Bahar, A., Keikha, M., Karbalaei, M., Kobyliak, N. M. & Yousefi, B. (2020). Probiotics function and modulation of the immune system in allergic diseases. Allergologia et Immunopathologia, 48(6), 771–788. http://doi.org/10.1016/j.aller.2020.04.005
Espín, J. C. (2017). Gut microbiota, diet and health. (We and our gut microbes). Molecular Nutrition and Food Research, 61(1), 1770015. https://doi.org/10.1002/mnfr.201770015
Fabusoro, O. K. & Mejia, L. A. (2021). Nutrition in HIV-Infected Infants and Children: Current Knowledge, Existing Challenges, and New Dietary Management Opportunities. Advances in Nutrition, 12(4), 1424-1437.https://doi.org/10.1093/advances/nmaa163
Fijan, S. (2014). Microorganisms with claimed probiotic properties: An overview of recent literature. International Journal of Environmental Research and Public Health, 11(5), 4745–4767. http://doi.org/10.3390/ijerph110504745
Gomaa, E. Z. (2020). Human gut microbiota/microbiome in health and diseases: A review. Antonie van Leeuwenhoek, 113(12), 2019–2040. http://doi.org/10.1007/s10482-020-01474-7
Gomes, A. C., Hoffmann, C. & Mota, J. F. (2018). The human gut microbiota: Metabolism and perspective in obesity. Gut Microbes, 9(4), 308–325. http://doi.org/10.1080/19490976.2018.1465157
Górska, A., Przystupski, D., Niemczura, M. J. & Kulbacka, J. (2019). Probiotic bacteria: A promising tool in cancer prevention and therapy. Current Microbiology, 76(8), 939–949. http://doi.org/10.1007/s00284-019-01679-8
Gupta, M., Gupta, R., Khunteta, A. & Swarnkar, S. (2017). An Overview of Asthma and its treatment. Journal of Biomedical and Pharmaceutical Research, 6(5), 32–36.
Gu, S., Yang, D., Liu, C. & Xue, W. (2023). The role of probiotics in prevention and treatment of food allergy. Food Science and Human Wellness, 12(3), 681-690.https://doi.org/10.1016/j.fshw.2022.09.001
Hamid, Q. & Tulic, M. (2009). Immunobiology of asthma. Annual Review of Physiology, 71, 489–507. http://doi.org/10.1146/annurev.physiol.010908.163200
Homayouni-Rad, A., Soroush, A. R., Khalili, L., Norouzi-Panahi, L., Kasaie, Z. & Ejtahed, H. S. (2017). Diabetes management by probiotics: Current knowledge and future pespective. International Journal for Vitamin and Nutrition Research, 1(1), 1–13. http://doi.org/10.1024/0300-9831/a000273
Hoyte, F. C. L. & Nelson, H. S. (2018). Recent advances in allergic rhinitis. F1000Research, 7. http://doi.org/10.12688/f1000research.15367.1
Iweala, O. I., Choudhary, S. K. & Commins, S. P. (2018). Food allergy. Current Gastroenterology Reports, 20(5), 17. http://doi.org/10.1007/s11894-018-0624-y
Jeong, J. J., Park, H. J., Cha, M. G., Park, E., Won, S. M., Ganesan, R., … & Suk, K. T. (2022). The lactobacillus as a probiotic: Focusing on liver diseases. Microorganisms, 10(2), 288.https://doi.org/10.3390/microorganisms10020288
Kapila, A., Chaudhary, S., Sharma, R. B., Vashist, H., Sisodia, S. S. & Gupta, A. (2016). A review on: Hiv aids. Indian Journal of Pharmaceutical and Biological Research, 4(3), 69-73.http://doi.org/10.30750/ijpbr.4.3.9
Kaur, K. K., Allahbadia, G. N. & Singh, M. (2020). Will probiotics provide the answer for therapy of nonalcoholic fatty liver disease (NAFLD). A systematic review. Biochemistry and Physiology, 9(257), 2.
Khaneghah, A. M., Abhari, K., Eş, I., Soares, M. B., Oliveira, R. B., Hosseini, H., … & Sant’Ana, A. S. (2020). Interactions between probiotics and pathogenic microorganisms in hosts and foods: A review. Trends in Food Science & Technology, 95, 205-218.https://doi.org/10.1016/j.tifs.2019.11.022
Khan, F. M., Morya, S. & Chattu, V. K. (2021). Probiotics as a boon in food diligence emphasizing the therapeutical role of probiotic beverages on consumers health. Journal of Applied and Natural Science, 13(2), 700–714. https://doi.org/10.31018/jans.v13i2.2683
Kim, S. K., Guevarra, R. B., Kim, Y. T., Kwon, J., Kim, H., Cho, J. H., … & Lee, J. H. (2019). Role of probiotics in human gut microbiome-associated diseases.https://doi.org/10.4014/jmb.1906.06064
Kocsis, T., Molnár, B., Németh, D., Hegyi, P., Szakács, Z., Bálint, A., … & Solymar, M. (2020). Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: a meta-analysis of randomized clinical trials. Scientific Reports, 10(1), 1-14. https://doi.org/10.1038/s41598-020-68440-1
Kopelman, P. G. (2000). Obesity as a medical problem. Nature, 404(6778), 635–643. http://doi.org/10.1038/35007508
Kumar, M. M. & Morya, S. (2022). Probiotics: Role of bioactives in foods and dietary supplements. Pharma Innovation Journal, 11(7), 2592-2597. https://doi.org/10.22271/tpi.2022.v11.i7ag.14368
Kumar, R., & Dhanda, S. (2017). Mechanistic insight of probiotics derived anticancer pharmaceuticals: A road forward for cancer therapeutics. Nutrition and Cancer, 69(3), 375–380. http://doi.org/10.1080/01635581.20 17.1267773
Ma, J., Zhou, Q. & Li, H. (2017). Gut microbiota and nonalcoholic fatty liver disease: insights on mechanisms and therapy. Nutrients, 9(10), 1124.http://doi.org/10.3390/nu9101124
Meirlaen, L., Levy, E.I. & Vandenplas, Y. (2021). Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review. Nutrients, 13(3), p.934.http://dx.doi.org/10.3390/nu13030934
Meroni, M., Longo, M. & Dongiovanni, P. (2019). The role of probiotics in nonalcoholic fatty liver disease: a new insight into therapeutic strategies. Nutrients, 11(11), 2642.http://doi.org/10.3390/nu11112642
Morya, S., Awuchi, C. G., Neumann, A., Napoles, J. & Kumar, D. (2022). Advancement in acidophilus milk production technology. In Advances in Dairy Microbial Products (pp. 105-116). Woodhead Publishing.https://doi.org/10.1016/B978-0-323-85793-2.00016-3
Morya, S., Chandra, R., & Seelam, B. S. (2017a). Microbial characteristics of whey and sorghum based low fat probiotic beverage. International Journal of Chemical Studies, 5(4), 403-406.
Morya, S., Chandra, R. & Thompkinson, D. K. (2017b). Organoleptic evaluation of low fat probiotic (Lactobacillus acidophilus) beverage prepared by whey and sorghum. The Pharma Innovation, 6(7), 153.
Niu, Y., Wang, C., Dong, X. & Zhong, N. (2021). Epigenetic Regulation of Th2 Response in Asthma by Non-Coding RNAs. In Recent Advances in Asthma Research and Treatments. IntechOpen.https://doi.org/10.5772/intechopen.97328
Oniszczuk, A., Oniszczuk, T., Gancarz, M. & Szymańska, J. (2021). Role of gut microbiota, probiotics and prebiotics in the cardiovascular diseases. Molecules, 26(4), 1172.http://doi.org/10.3390/molecules26041172
Pascal, M., Perez-Gordo, M., Caballero, T., Escribese, M. M., Lopez Longo, M. N., Luengo, O., ... & Mayorga, C. (2018). Microbiome and allergic diseases. Frontiers in Immunology, 9, 1584.http://doi.org/10.3389/fimmu.2018.01584
Patterson, E., Ryan, P. M., Cryan, J. F., Dinan, T. G., Ross, R. P., Fitzgerald, G. F. & Stanton, C. (2016). Gut microbiota, obesity and diabetes. Postgraduate Medical Journal, 92(1087), 286-300.http://doi.org/10.1136/postgradmedj-2015-133285
Plaza-Díaz, J., Ruiz-Ojeda, F. J., Vilchez-Padial, L. M., & Gil, A. (2017). Evidence of the anti-inflammatory effects of probiotics and synbiotics in intestinal chronic diseases. Nutrients, 9(6), 555.http://doi.org/10.3390/nu9060555
Rai, N., Singh, A. K., Keshri, P. K., Barik, S., Kamble, S. C., Singh, S. K., ... & Gautam, V. (2021). Probiotics for management of gastrointestinal cancers. In Probiotic Research in Therapeutics (pp. 191-209). Springer, Singapore.http://doi.org/10.1007/978-981-15-8214-1_9
Rittiphairoj, T., Pongpirul, K., Janchot, K., Mueller, N. T. & Li, T. (2021). Probiotics contribute to glycemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Advances in Nutrition, 12(3), 722-734.https://doi.org/10.10 93/advances/nmaa133
Rodrigues, M. X., Lima, S. F., Higgins, C. H., Canniatti-Brazaca, S. G. & Bicalho, R. C. (2016). The Lactococcus genus as a potential emerging mastitis pathogen group: A report on an outbreak investigation. Journal of Dairy Science, 99(12), 9864-9874.http://doi.org/10.3168/jds.2016-11143
Ruszczyński, M. & Feleszko, W. (2016). Probiotics and prebiotics for the prevention or treatment of allergic asthma.http://doi.org/10.10 16/B978-0-12-802189-7.00066-6
Safari, Z. & Gérard, P. (2019). The links between the gut microbiome and nonalcoholic fatty liver disease (NAFLD). Cellular and Molecular Life Sciences, 76(8), 1541-1558.http://doi.org/10.1007/s00018-019-03011-w
Salgaço, M. K., Oliveira, L. G. S., Costa, G. N., Bianchi, F. & Sivieri, K. (2019). Relationship between gut microbiota, probiotics, and type 2 diabetes mellitus. Applied Microbiology and Biotechnology, 103(23), 9229-9238.http://doi.org/10.1007/s00253-019-10156-y
Sánchez, B., Delgado, S., Blanco‐Míguez, A., Lourenço, A., Gueimonde, M. & Margolles, A. (2017). Probiotics, gut microbiota, and their influence on host health and disease. Molecular Nutrition & Food research, 61(1), 1600240.http://doi.org/10.1002/mnfr.201600240
Schuler IV, C. F. & Montejo, J. M. (2021). Allergic rhinitis in children and adolescents. Immunology and Allergy Clinics, 41(4), 613-625.http://doi.org/10.1016/j.pcl.2019.06.004
Sen, M. (2019). Role of probiotics in health and disease–A review. International Journal of Advancement in Life Sciences Research, 1-11.https://doi.org/10.31632/ijalsr.2019v02i02.001
Serra, D., Almeida, L. M. & Dinis, T. C. (2019). The impact of chronic intestinal inflammation on brain disorders: The microbiota-gut-brain axis. Molecular Neurobiology, 56(10), 6941-6951.http://doi.org/10.1007/s12035-019-1572-8
Sestito, S., D'Auria, E., Baldassarre, M. E., Salvatore, S., Tallarico, V., Stefanelli, E., ... & Pensabene, L. (2020). The role of prebiotics and probiotics in prevention of allergic diseases in infants. Frontiers in Pediatrics, 870.http://doi.org/10.3389/fped.2020.583946
Śliżewska, K., Markowiak-Kopeć, P. & Śliżewska, W. (2020). The Role of Probiotics in Cancer Prevention. Cancers, 13(1), p.20.http://doi.org/10.3390/cancers13010020
Small, P., Keith, P. K. & Kim, H. (2018). Allergic rhinitis. Allergy, Asthma & Clinical Immunology, 14(2), 1-11.http://doi.org/10.1186/1710-1492-7-S1-S3
So, S. S., Wan, M. L., & El-Nezami, H. (2017). Probiotics-mediated suppression of cancer. Current Opinion in Oncology, 29(1), 62-72.http://doi.org/10.1097/CCO.0000000000000342
Syiemlieh, I. & Morya, S. (2022). Dairy and non-dairy based probiotics: A review. Pharma Innovation Journal, 11, 2956-2964.https://doi.org/10.22271/tpi.2022.v11.i6Sak.13568
Tagg, J. R., Wescombe, P. A., Burton, J. P. & Wescombe, P. A. (2011). Streptococcus: a brief update on the current taxonomic status of the genus. Lactic Acid Bacteria, 123-146.
Tang, R.-B., Chang, J.-K. & Chen, H.-L. (2015). Can probiotics be used to treat allergic diseases? Journal of the Chinese Medical Association, 78(3), pp.154–157.http://doi.org/10.1016/j.jcma.2014.08.015
Tarhani, F. & Nezami, A. (2019). Role of probiotics in treatment of congenital heart disease and necrotizing enterocolitis. Pharma Nutrition, 8, 100144.https://doi.org/10.1016/j.phanu.2019.100144
Thilakarathna, W. P., Rupasinghe, H. P. & Ridgway, N. D. (2021). Mechanisms by which probiotic bacteria attenuate the risk of hepatocellular carcinoma. International Journal of Molecular Sciences, 22(5), 2606.http://doi.org/10.3390/ijms22052606
Torres, T., Ferreira, E., Gonçalo, M., Mendes-Bastos, P., Selores, M. & Filipe, P. (2019). Update on atopic dermatitis. Acta Medica Portuguesa, 32(9), 606-613.http://doi.org/10.20344/amp.11963
Trefts, E., Gannon, M. & Wasserman, D.H. (2017). The liver. Current Biology, 27(21), pp.R1147–R1151.http://doi.org/10.101 6/j.cub.2017.09.019
Upadhyay, J., Farr, O., Perakakis, N., Ghaly, W. & Mantzoros, C. (2018). Obesity as a Disease. Medical Clinics of North America, 102(1), pp.13–33.http://doi.org/10.1016/j.mcna.2017.08.004
Valdes, A. M., Walter, J., Segal, E. & Spector, T. D. (2018). Role of the gut microbiota in nutrition and health. Bmj, 361.http://doi.org/10.1136/bmj.k2179
Wan, M. L. & El-Nezami, H. (2018). Targeting gut microbiota in hepatocellular carcinoma: probiotics as a novel therapy. Hepatobiliary Surgery and Nutrition, 7(1), 11.http://dx.doi.org/10.21037/hbsn.2017.12.07
Welch, R. A. (2006). The genus escherichia. Prokar yotes, 6(1), 60-71.http://doi.org/10.1007/0-387-30746-X_3
Yang, C.-Y., Zhang, F.-Y. & Wang, I.-J. (2022). Probiotics’ Efficacy in Preventing Asthmatic Allergic Reaction Induced by Air Particles: An Animal Study. Nutrients, 14(24), 5219.https://doi.org/10.3390/nu14245219
Yao, M., Qv, L., Lu, Y., Wang, B., Berglund, B. & Li, L. (2021). An update on the efficacy and functionality of probiotics for the treatment of nonalcoholic fatty liver disease. Engineering, 7(5), 679-686.http://doi.org/10.1016/j.eng.2020.01.017
Yoo, J. Y., Groer, M., Dutra, S. V. O., Sarkar, A. & McSkimming, D. I. (2020). Gut microbiota and immune system interactions. Microorganisms, 8(10), 1587.https://doi.org/10.3390/microorganisms8101587
Yu, W., Freeland, D. M. H. & Nadeau, K. C. (2016). Food allergy: immune mechanisms, diagnosis and immunotherapy. Nature Reviews Immunology, 16(12), 751-765. http://doi.org/10.1038/nri.2016.111
Zeigler, D. R., & Perkins, J. B. (2015). 27 The Genus Bacillus. Practical Handbook of Microbiology, 429. http://doi.org/10.1201/9781420 009330.ch24
Zheng, J., Wittouck, S., Salvetti, E., Franz, C. M., Harris, H., Mattarelli, P., ... & Lebeer, S. (2020). A taxonomic note on the genus Lactobacillus: Description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae. http://doi.org/10.1099/ijsem.0.004107
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The Gut microbiota and chronic diseases: Role of probiotics: Gut Microbiota. (2023). Journal of Applied and Natural Science, 15(2), 692-703. https://doi.org/10.31018/jans.v15i2.4540