Normalizing of estrous cycle in polycystic ovary syndrome (PCOS) induced rats with Tephrosia purpurea (Linn.) Pers.
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Abstract
This study evaluates the potentiality of an herbal plant Tephrosia purpurea (Linn.) Pers. in the treatment of Letrozole induced polycystic ovary syndrome (PCOS) using female Albino wistar rats. Seed powder of T. purpurea at concentration of 200 mg/kg body weight with milk as a carrier vehicle 3ml/kg body weight, given for at least 3 consecutive estrous cycles. Vaginal smear, FSH, LH, Testosterone, and Estrogen were analyzed to determine the fluctuations in sex steroid level in PCOS induced rats. The plasma testosterone and estrogen level
were found to be significantly increased in rats with PCOS whereas Follicle stimulating hormone and Leutinizing hormone did not show any changes. When compared with control the PCOS induced rats showed characteristic ovary with high incidence of ovarian cyst. All the parameters assessed were significantly improved after the treatment with T. purpurea and achieved level close to 80% normalcy. Effect of T. purpurea significantly reduced histopathological changes in ovary and endocrinological and biochemical changes induced by hyperandrogenism. Further to check ovulation and fertility female rats were mated and pregnancy was confirmed. Thus potential of T. purpurea in the treatment of PCOS using an animal model suggested being a good alternative therapy in the treatment of PCOS.
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Carboxymethylecellulose, Estrogen, Estrous cycle, Letrozole, Polycystic ovary syndrome, Testosterone, Tephrosia purpurea
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