Phytoremedial effect of Asparagus racemosus on sodium arsenite-induced toxicity in Charles Foster rats
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Abstract
Arsenic poisoning has recently resulted in significant health problems in the exposed population. In India, the Indo-Gangetic plains are the region where the arsenic threat has increased. In Bihar, it is estimated that 10 million people are exposed to arsenic poisoning. The present study aims to develop a novel drug as an antidote against arsenic-induced toxicity in rats. In the present study, arsenic in sodium arsenite at a dose of 8 mg/kg body weight per day was induced (Group-II) in Charles Foster rats at 2 or 6 months to observe chronic exposure. In the arsenic pretreated group (Group-III), Asparagus racemosus was administered at a dose of 400 mg/kg body weight per day for 8 weeks. Normal control group (Group I) was taken without any treatment. After completion of the entire experiment, the animals were sacrificed, and their blood samples were obtained for hematological and biochemical evaluation. At the same time, vital tissues, such as the liver and kidney, were fixed in preservatives for the histopathological study. The study showed that the hematological levels, such as RBC, WBC, platelet counts and hemoglobin percentage, were significantly restored by administering A. racemosus (Group-III), against the arsenic-exposed group. Furthermore, biochemical parameters such as SGPT, SGOT, ALP, bilirubin, urea, uric acid and creatinine were significantly recovered (p<0.05) against arsenic-induced toxicity. The histopathological study also showed remarkable restoration in hepatocytes and nephrocytes by A. racemosus against arsenic-induced toxicity. Therefore, it can be concluded from the entire study that A. racemosus has a significant antidote effect against arsenic-induced toxicity.
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Keywords
Arsenic treatment, A.racemosus, Charles Foster rats, Drug development
References
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Kumar, A., Ali, M., Kumar, R., Kumar, M., Sagar, P., Pandey, R.K., Akhouri, V., Kumar, V., Anand, G., Niraj, P.K., Rani, R., Kumar, S., Kumar, D., Bishwapriya, A., Ghosh, A.K., (2021a). Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk. Scientific Reports. 11(1):2376. https://doi.org/10.1038/s41598-021-81579-9.
Kumar, A., Kumar, V., Akhouri, V., Kumar R., Ali., M, Rashmi T., Chand G.B., Singh S.K., Ghosh A.K. (2022): Protective efficacy of Coriandrum sativum seeds against arsenic induced toxicity in Swiss albino mice. Toxicol Res. (2022). https://doi.org/10.1007/s43188-022-00123-7.
Kumar, A., Ali, M., Kumar, R., Rahman, M.S., Srivastava, A., Chayal, N.K., Sagar, V., Kumari, R., Parween, S., Kumar, R., Niraj, P.K., Anand, G., Singh, S.K., Ghosh, A.K., (2020a). High arsenic concentration in blood samples of people of village Gyaspur Mahaji, Patna, Bihar drinking arsenic contaminated water. Springer Nature J Expos Health. 12, 131–140. https://doi.org/10.1007/s12403-018-00294-5.
Kumar, V., Akhouri, V., Singh, S. K., & Kumar, A. (2020b). Phytoremedial effect of Tinospora cordifolia against arsenic induced toxicity in Charles Foster rats. Biometals: an International Journal on the role of Metal Ions in Biology, Biochemistry, and Medicine, 33(6), 379–396. https://doi.org/10.1007/s10534-020-00256-y.
Kumar, A., Ali, Md., Rahman, S.Md., Iqubal, A.Md., Anand, G., Niraj, P.K., Srivastava, A., Kumar, R., Gahlot, V., (2015). Ground Water Arsenic Poisoning in “Tilak Rai Ka Hatta” Village of Buxar District, Bihar, India Causing Severe Health Hazards and Hormonal Imbalance. J. Environ Anal Toxicol., 5, 290.
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Kumar, A., Kumar, R., Rahman, M.S., Ali, M., Kumar, R., Nupur, N., Gaurav, A., Raj, V., Anand, G., Niraj, P. K., Kumar, N., Srivastava, A., Biswapriya, A., Chand, G.B., Kumar, D., Rashmi, T., Kumar, S., Sakamoto, M., Ghosh, A.K., (2021c). Assessment of arsenic exposure in the population of Sabalpur village of Saran District of Bihar with mitigation approach. Environmental Science and Pollution Research International, 10.1007/s11356-021-13521-5. Advance online publication. https://doi.org/10.1007/s11356-021-13521-5.
Kumar, A., Rahman, M.S., Ali, M., Kumar, R., Niraj, P.K., Akhouri, V., Singh, S.K., Kumar, D., Rashmi, T., Bishwapriya, A., Chand G.B., Sakamoto, M., Ghosh, A.K., (2021d). Assessment of arsenic exposure and its mitigation intervention in severely exposed population of Buxar district of Bihar, India. Toxicol. Environ. Health Sci. https://doi.org/10.1007/s13530-021-00086-6.
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Phytoremedial effect of Asparagus racemosus on sodium arsenite-induced toxicity in Charles Foster rats . (2022). Journal of Applied and Natural Science, 14(2), 302-309. https://doi.org/10.31018/jans.v14i2.3164
