Antifertility effects of Solanum xanthocarpum seeds on female albino rats
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Abstract
The effect of Solanum xanthocarpum seed powder as aqueous suspension on genital organs and fertility of female albino rats was studied at doses of 50, 100 & 150 mg/kg/day for 30 days.Tthe genital organ weight of albino rats was reduced significantly (P<0.05) after the treatment at 100 and 150 mg/kg doses of seed powder of S. xanthocarpum.for 30 days.The higher doses caused histopathological changes in the ovary and uterus leading to 100% control of fertility as no implants were recorded in treated female rats on the day 10th of pregnancy.
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Keywords
Contraception, Fertility control, Genital organs, Herbal drugs, Solanum xanthocarpum
References
Agarwal, O.P., Bhardwaj, S. and Mathur, R. (1980). Antifertility effects of fruits of Juniperus communis. Planta Medica. (Supl.), 98101.
Aswal, B.S.; Bhakuni, D.S.; Goel, A.K.; Kar, K.; Mehrotra, B.N. and Mukherjee, K. (1984). Screening of Indian plants for Biological activity. Part X. Indian J. Exp. Biol., 22 : 312-332.
Balamurugan, K., Kalaichelvan, V.K.. Anuradha, G., Madhana Gopal, K., Meganathan, M. and Manavalan, R. (2009). Antifertility activity of Methanolic extract of Saccharum officinarum Linn. (leaves) on female albino rats. Int. Pharm. Tech. Res., 1(4) : 1621-1634.
Bhardwaj, S. and Mathur, R. (1979). Antifertility screening of fruits of Cassia fistula Linn. In female albino rats. Comp. Physiol. Ecol., 4 (4) 277 - 279.
Chaudhury. R.R. (1966). Plants with possible antifertility activity. Special report series No. 55, I.C.M.R., New Delhi.
Chakraborti, B. Chaudhary, A. and Chaudhury, R.R. (1968). Antifertility effect of green leaves of Artobotrys odoratissimus. J. Indian Med. Asso., 31 (5): 227 - 229.
Dixit, V.P. (1977). Effect of Chronically administration of Malva viscus conzattii flower extract on the female genital tract of gerbil, Merionis hurrianae, Jerdon. Indian J. Exp. Biol., 15 (8): 1650-1652.
Dixit, V.P. and Gupta R.S. (1982). Antispermatogenitic/antiandrogenic properties of solasodine obtained from Solanum xanthocarpum berries on the male genital tract of dog (canis familiries) a histophysiological approach. Intern. J. Androl., 4:1 - 8.
Farnsworth, N.R., Bingel, A.S., Cordell, S.A., Crane, F.A. and Fong H.H.S. (1975). Potential value of plants as sources of new antifertility agents. l. J. Pharma. Sci. U.S.A., 64 (4): 535 - 558.
Jain, C.M. and Bharathi, K. (2011). Critical Review of Scientific validity of indigenous female contraceptive drugs described in Ayurvedic literature. Indian J. Trad. Knowl., 10(4) : 678-681.
Kholkute, S.D. and Udupa, K.N. (1974). Antifertility properties of Hibiscus rosa sinensis Linn. J. Res. Indian Med., 9 (4): 99 - 102.
Kholkute, S.D., Chatterjee, S. and Udupa, K.N. (1976). Effect of Hibiscus rosa sinensis Linn. on oestrus cycle and reproductive organs in rats. Indian J. Exp. Biol., 14 (11): 703 - 704.
Lal, B. and Udupa, K.N. (1993) . A preliminary study of antifertility effect of an indigenous drug – Arjuna (Terminalia arjuna). Jour. Res. Ayur. Siddha, 14(1) : 165-169.
Munshi, S.R. and Rao, S.S. (1972). Antifertility activity of an indigenous plant preparation ROC 101. Effect on reproduction. Indian J. Med. Res. 60: 1054 - 1060.
Padmashali, B.; Vaidya, V.P.; Vagdevi, H.M. and Satyanarayana, N.D. (2006). Antifertility efficacy of the plant Balanites roxburghii (Balanitaceae) in female rats. Indian J. Pharma. Sci., 68(3) : 347-351.
Pathania, P.C.; Singh, S.P. and Bhatia, D.K. (2000). Effect of Lantana camara Linn. leaves on ovarian and uterine histology, oestrus cycle and ovulation in Albino rats. Indian Jour. Env. Sci., 4(1) : 53-60.
Pokharkar, R.D.; Saraswat, R.K. and Sheetal Kotkar (2010). Survey of plants having antifertility activity from Western ghat area of Maharashtra state. Jour. Herb Med. Toxicol., 4(2) : 71-75
Prakash, A.O. (1979). Effect of Embelia ribes Burm. Extracts on the uterus of rat: a histological study. Probe, 18 (3): 178- 184.
Rao, M.V. (1986). Effect of Solanum xanthocarpum seed extracts on reproductive organs of male rats. Bio Sci. Res. Bull., 2: 22 - 28
Rao, M.V. (1988). Effect of alcoholic extract of Solanum xanthocarpum seeds in adult male rats. Indian J. Exp. Biol., 26: 95 - 98.
Sharma, R.K., Chopra, G., Gyan Bhushan and Munjal, K. (2003). Use of Indian medicinal plants for infertility regulation in mammal. J. Exp. Zool., 6(1) : 57-74.
Aswal, B.S.; Bhakuni, D.S.; Goel, A.K.; Kar, K.; Mehrotra, B.N. and Mukherjee, K. (1984). Screening of Indian plants for Biological activity. Part X. Indian J. Exp. Biol., 22 : 312-332.
Balamurugan, K., Kalaichelvan, V.K.. Anuradha, G., Madhana Gopal, K., Meganathan, M. and Manavalan, R. (2009). Antifertility activity of Methanolic extract of Saccharum officinarum Linn. (leaves) on female albino rats. Int. Pharm. Tech. Res., 1(4) : 1621-1634.
Bhardwaj, S. and Mathur, R. (1979). Antifertility screening of fruits of Cassia fistula Linn. In female albino rats. Comp. Physiol. Ecol., 4 (4) 277 - 279.
Chaudhury. R.R. (1966). Plants with possible antifertility activity. Special report series No. 55, I.C.M.R., New Delhi.
Chakraborti, B. Chaudhary, A. and Chaudhury, R.R. (1968). Antifertility effect of green leaves of Artobotrys odoratissimus. J. Indian Med. Asso., 31 (5): 227 - 229.
Dixit, V.P. (1977). Effect of Chronically administration of Malva viscus conzattii flower extract on the female genital tract of gerbil, Merionis hurrianae, Jerdon. Indian J. Exp. Biol., 15 (8): 1650-1652.
Dixit, V.P. and Gupta R.S. (1982). Antispermatogenitic/antiandrogenic properties of solasodine obtained from Solanum xanthocarpum berries on the male genital tract of dog (canis familiries) a histophysiological approach. Intern. J. Androl., 4:1 - 8.
Farnsworth, N.R., Bingel, A.S., Cordell, S.A., Crane, F.A. and Fong H.H.S. (1975). Potential value of plants as sources of new antifertility agents. l. J. Pharma. Sci. U.S.A., 64 (4): 535 - 558.
Jain, C.M. and Bharathi, K. (2011). Critical Review of Scientific validity of indigenous female contraceptive drugs described in Ayurvedic literature. Indian J. Trad. Knowl., 10(4) : 678-681.
Kholkute, S.D. and Udupa, K.N. (1974). Antifertility properties of Hibiscus rosa sinensis Linn. J. Res. Indian Med., 9 (4): 99 - 102.
Kholkute, S.D., Chatterjee, S. and Udupa, K.N. (1976). Effect of Hibiscus rosa sinensis Linn. on oestrus cycle and reproductive organs in rats. Indian J. Exp. Biol., 14 (11): 703 - 704.
Lal, B. and Udupa, K.N. (1993) . A preliminary study of antifertility effect of an indigenous drug – Arjuna (Terminalia arjuna). Jour. Res. Ayur. Siddha, 14(1) : 165-169.
Munshi, S.R. and Rao, S.S. (1972). Antifertility activity of an indigenous plant preparation ROC 101. Effect on reproduction. Indian J. Med. Res. 60: 1054 - 1060.
Padmashali, B.; Vaidya, V.P.; Vagdevi, H.M. and Satyanarayana, N.D. (2006). Antifertility efficacy of the plant Balanites roxburghii (Balanitaceae) in female rats. Indian J. Pharma. Sci., 68(3) : 347-351.
Pathania, P.C.; Singh, S.P. and Bhatia, D.K. (2000). Effect of Lantana camara Linn. leaves on ovarian and uterine histology, oestrus cycle and ovulation in Albino rats. Indian Jour. Env. Sci., 4(1) : 53-60.
Pokharkar, R.D.; Saraswat, R.K. and Sheetal Kotkar (2010). Survey of plants having antifertility activity from Western ghat area of Maharashtra state. Jour. Herb Med. Toxicol., 4(2) : 71-75
Prakash, A.O. (1979). Effect of Embelia ribes Burm. Extracts on the uterus of rat: a histological study. Probe, 18 (3): 178- 184.
Rao, M.V. (1986). Effect of Solanum xanthocarpum seed extracts on reproductive organs of male rats. Bio Sci. Res. Bull., 2: 22 - 28
Rao, M.V. (1988). Effect of alcoholic extract of Solanum xanthocarpum seeds in adult male rats. Indian J. Exp. Biol., 26: 95 - 98.
Sharma, R.K., Chopra, G., Gyan Bhushan and Munjal, K. (2003). Use of Indian medicinal plants for infertility regulation in mammal. J. Exp. Zool., 6(1) : 57-74.
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How to Cite
Antifertility effects of Solanum xanthocarpum seeds on female albino rats. (2013). Journal of Applied and Natural Science, 5(1), 153-156. https://doi.org/10.31018/jans.v5i1.299
