Optimization with genetic algorithms of chlorogenic acid's extraction and purification from native potato (Solanum tuberosum L.) peel, using an aqueous two-phase system
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Abstract
Chlorogenic acid is one of the main phenolic components of potatoes (Solanum tuberosum L.). Researchers have demonstrated that this phenolic compound is a higher concentration in the native Huagalina potato peel and is also found in the whole tuber's cooking water. This research aims to extract and purify chlorogenic acid (CGA) from potato Huagalina peel obtained from discarded manufacturing for snacks, using an Aqueous Two-Phase System (ATPS). The central composite design rotatable (CDDR); Response Surface Methods (RSM) in R x 64 4.0.3 and RSM package was used to identify the regions of interest that resulted in the best extraction levels. The concentration of ethanol (EtOH) and disodium phosphate (DSP) were selected as factors capable of affecting CGA performance. Extraction efficiency values for concentrations were optimized using genetic algorithms (GA) applying the R package GA. . In the present research, a high value of 0.8 was applied, which produced new "offspring" solutions, which share some good characteristics taken from both parents. The mutation is applied after the crossover, altering some genes in the chains, which was 0.1. According to what has been reported, the offspring can replace the entire population or replace individuals with less aptitude. This evaluation cycle and selection-reproduction cycle were repeated until a satisfactory recovery of CGA (97.2%) estimated with GA at a pH of 3.4 (25ºC) was achieved, yielding 443.7 ± 0.062 mg CGA / 100 g dry weight of potato peels.
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Keywords
ATPS, Chlorogenic acid, Genetic algorithms, Native potato, Potato peels
References
ADEX. (2016). Asociación de Exportadores. Exportación de papa peruana. http://andina.pe/agencia/noticia.aspx?id=668919
André, Ch., Oufir, M., Hoffmann, L., Hausman, J., Rogez, H., Larondelle, Y., Evers, D. (2009). Influence of environment and genotype on polyphenol compounds and in vitro antioxidant capacity of native Andean potatoes (Solanum tuberosum L.). Journal of Food Composition and Analysis, 22, 517-524. https://doi.org/10.1016/j.jfca.2008.11.010
Aydo?an, Ö., Bayraktar, E., Mehmeto?lu, Ü., Kaeding, T. and Zeng, A. P. (2010). Selection and optimization of an aqueous two-phase system for the recovery of 1, 3, propanediol from fermentation broth. Engineering in Life Sciences, 10(2), 121-129. https://doi.org/10.1002/elsc.20 0900084
Bandyopadhyay, G., Biswas, T., Roy, K. C., Mandal, S., Mandal, C., Pal, B. C. and Konar, A. (2004). Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells. Blood, 104(8), 2514-2522. https://doi.org/10.1182/blood-2003-11-4065
Benavides, J. and Rito-Palomares, M. (2008). Aplicación genérica de sistemas de dos fases acuosas polietilenglicol-sal para el desarrollo de procesos de recuperación primaria de compuestos biológicos. Revista Mexicana de Ingeniería Química, 7(2), 99111. http://www.scielo.or g.mx/scielo.php?script=sci_arttext&pid=S166527 382008000200002&lng=es&tlng=es.
Bender, O. and Atalay, A. (2021). Polyphenol chlorogenic acid, antioxidant profile, and breast cancer. In Cancer (pp. 311-321). Academic Press. https://doi.org/10.1016/B978-0-12-819547-5.00028-6
Casas, P. and Daniel, H. (2017). Análisis de las restricciones que influyen en la competitividad de la cadena productiva de papas nativas (Solanum tuberosum) en la región Apurímac. [tesis de bachiller, Universidad Nacional José María Arguedas]. Repositorio Institucional UNAJMA. http://repositorio.unajma.edu.pe/handle/12345 6789/317
Cerón, L. and López, I. (2013). Extracción y cuantificación de compuestos con actividad antioxidante a partir de cáscaras de tres variedades de papa (Solanum tuberosum) en el departamento de Nariño. [Tesis de grado, Universidad de Nariño]. Sistema de Recursos digitales UN. http://sired.udenar.edu.co/2454/
Cheng, Z., Song, H., Cao, X., Shen, Q., Han, D., Zhong, F. and Yang, Y. (2017). Simultaneous extraction and purification of polysaccharides from Gentiana scabra Bunge by microwave-assisted ethanol-salt aqueous two-phase system. Industrial Crops and Products, 102, 75-87. https://doi.org/10.1016/j.indcrop.2017.03.029
Chon, K.Y. and Su-Ling, M. (2021). Effects of recycling on the aqueous two-phase extraction of bioactives from haskap leaves. Separation and Purification Technology, 255, 117755. https://doi.org/10.1016/j.seppur.2020.11 775 5
Cienfuegos, N. E. C., Santos, P. L., García, A. R., Soares, C. M. F., Lima, A. S. and Souza, R. L. (2017). Integrated process for purification of capsaicin using aqueous two-phase systems based on ethanol. Food and Bioproducts Processing, 106, 1-10. https://doi.org/10.101 6/j.fbp.201 7.08.005
Cortés-Burgos, M. P. (2008). Predicción del coeficiente de partición de proteínas en sistemas de dos fases acuosas a través de la caracterización bioinformática de su superficie. [tesis de grado, Universidad de Chile]. Repositorio Institucional UC. http://repositorio.uchile.cl/handle/225 0/1 03095
Dutra-Molino, J., Feitosa, V. A., de Lencastre-Novaes, L. C., Santos-Ebinuma, V., Lopes A. M., Jozala, A. F., Marques D. de A, V., Pellegrini-Malpiedi, L. and Pessoa-Júnior, A. (2014). Biomolecules extracted by ATPS: Practical examples. Revista Mexicana de Ingeniería Química, 13(2), 359-377. https://ri.conicet.gov.ar/handle/11 336/ 12064
Flores, C. F. (2017). Análisis de los factores que inciden en la baja productividad de 5 variedades de papa nativa en la Provincia de Cotabambas, Región Apurímac [tesis de grado, Universidad Nacional de San Agustín]. Repositorio Institucional UNSA. http://repositorio.unsa.edu.pe/handle/UNSA/2725
Gutiérrez, H. and Vara, R. (2012). Análisis y diseño de experimentos, 2. ª ed. Mc Graw Hill, México. https://gc.scalahed.com/recursos/files/r161r/w19537w/analisi s_y_diseno_experimentos.pdf
Huang, A., Deng, W., Wu. D., Wu, S. and Xiao, Y. (2019). Hexafluorisopropanol-salt aqueous two-phase system for extraction and purification of chlorogenic acid from ramie leaves. Journal of Chromatography A, 1597, 196-201. https://doi.org/10.1016/j.chroma.2019.04.046
Iqbal, M., Tao, Y., Xie, S., Zhu, Y., Chen, D., Wang, X. and Hussain, H. I. (2016). Aqueous two-phase system (ATPS): an overview and advances in its applications. Biological procedures online, 18(1), 18. https://doi.or g/10.1186/s12575-016-0048-8
López-Méndez, I. C., Ríos, G. and De Sarón, R. (2014). Determinación del contenido de ácido clorogénico por Espectroscopía UV-VIS en hojas secas y verdes de Cecropia peltata (Guarumo) en árboles silvestres de 10, 15, y 20 M de altura en la reserva natural laguna de apoyo [tesis de doctorado, Universidad Nacional Autónoma de Nicaragua, Managua). Repositorio UNAN. https://repositorio.unan.edu.ni/5369/
Malpiedi, L. P., Nerli, B. B., Abdala, D. S., de Alcântara Pessôa-Filho, P. and Pessoa, A. (2014). Aqueous micellar systems containing Triton X-114 and Pichia pastoris fermentation supernatant: A novel alternative for single chain-antibody fragment purification. Separation and Purification Technology, 132, 295-301. https://doi.org/1 0.1016/j.seppur.2014.05.045
Mariajayaprakash, A., Senthilvelan, T. and Gnanadass, R. (2015). Optimization of process parameters through fuzzy logic and genetic algorithm–A case study in a process industry. Applied Soft Computing, 30, 94-103. https://doi.org/10.1016/j.asoc.2015.01.042
Morales, C. A. D., Medina, S. E. L., Salvatierra, C. R. Z., Barrantes, M. Y. R. and Viera, J. P. H. (2015). Cuantificación de los principios anticancerígenos de la variedad de papa nativa de pulpa de color de la región La Libertad con el fin de procesamiento industrial. Pueblo Continente, 24(2), 425-431. http://journal.upao.edu.pe/Puebl oContinente/article/view/58
Mu, T., Sun, H., Zhang, M. and Wang, C. (2017). Sweet potato processing technology. Academic Press, 7(1),357-403. https://doi.org/10.1016/B978-0-12-812871-8.00001-5
Myers, R ., Montgomery, D., Anderson-Cook (2016)Response Surface Methodology (Process and Product Optimization Using Designed Experiments). Second Edition. John Wiley & Sons.
Narváez-Cuenca, C. E., Vincken, J. P. and Gruppen, H. 2012. Identification and quantification of (dihydro) hydroxycinnamic acids and their conjugates in potato by UHPLC–DAD–ESI-MSn. Food Chemistry, 730-738. https://doi.org/10.1016/j.foodchem.2011.04.050
Naveed, M., Hejazi, V., Abbas, M., Kamboh, A. A., Khan, G. J., Shumzaid, M., ... & XiaoHui, Z. (2018). Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomedicine & Pharmacotherapy, 97, 67-74. https://doi.org/10.1016/j.biopha.2017.10.064
Nemati-Knade, E., Shekaari, H. and Jafari, S. A. (2012). Thermodynamic study of aqueous two-phase systems for some aliphatic alcohols+ sodium thiosulfate+ water. Fluid phase equilibria, 321, 64-72. https://doi.org/10.1016/j.flui d.2012.02.015
Peña, E. F. (2017). Extracción y caracterización fisicoquímica y funcional de almidones de cinco variedades de papas nativas procedentes de Ilave (Puno) [tesis de grado, Universidad Agraria la Molina]. Repositorio Institucional UNALM http://repositorio.lamolina.edu.pe/handle/UN ALM/2655
Rojas-Padilla, C. and Vásquez-Villalobos, V. (2016). Phenolic compounds with antioxidant capacity of the native Andean potato (Solanum tuberosum L.) Huagalina variety in La Libertad-Peru. Scientia Agropecuaria, 7(3), 333-340. http://dx.doi.org/10.17268/sci.agropecu.201 6.0 3.22.
Rojas-Padilla, C, Vásquez-Villalobos, V., Elber, C., Rojas, J. C., Ríos, N. H., Lujan, A. P., Ninaquispe, P. and Espinoza, S. (2018). Phenolic compounds in native potato (Solanum tuberosum L.) cooking water, with potential antioxidant activity. Food Science and Technology, 39 (1), 66-71. https://www.scielo.br/s cielo.php?scrip t=sc i_arttext&pid=S0101-20612019000100066&tl ng=en
Sandoval, M. H., Tenorio-Mucha, J., Tinco-Jayo, A., Loli-Ponce, R. A. and Calderón-Pinillos, S. (2015). Efecto antioxidante y citoprotector del tocosh de Solanum tuberosum papa en la mucosa gástrica de animales de experimentación. In Anales de la Facultad de Medicina, 76(1), 15 - 20. http://dx.doi.org/10.15381/anales.v76i1.11070
Siswanto, F. M., Oguro, A. and Imaoka, S. (2017). Chlorogenic acid modulates hypoxia response of Hep3B cells. Personalized Medicine Universe, 6, 12-16. https://doi.org/10.1016/j.pmu.2017.03.001
Soto-García, M. and Rosales-Castro, M. (2016). Efecto del solvente y de la relación masa/solvente, sobre la extracción de compuestos fenólicos y la capacidad antioxidante de extractos de corteza de Pinus durangensis y Quercus sideroxyla. Maderas. Ciencia y tecnología, 18(4), 701-714. http://dx.doi.org/10.4067/S0718-221X2016 0050 00061
Souza, R. L., Lima, R. A., Coutinho, J. A., Soares, C. M. and Lima, Á. S. (2015). Novel aqueous two-phase systems based on tetrahydrofuran and potassium phosphate buffer for purification of lipase. Process Biochemistry, 50(9),1459-1467. https://doi.org/10.1016/j.procbio.2015.05.01 5
Sukrasno, Y. and Kusmardiyani, S. (2014). Influence of Cooking Methods on Chlorogenic Acid Content of Potato Peels (Solanum tuberosum L.). International Journal of Pharmacognosy and Phytochemical Research, 6(3), 488-491. https://pdfs.semanticscholar.org/626a/eee3249109 23442a5aa2c1a7abe6ede32254.pdf
Tan, Z., Wang, C., Yi, Y., Wang, H., Li, M., Zhou, W. and Li, F. (2014). Extraction and purification of chlorogenic acid from ramie (Boehmeria nivea L. Gaud) leaf using an ethanol/salt aqueous two-phase system. Separation and Purification Technology, 132, 396-400. https://doi.or g/10.1016/j.seppur.2014.05.048
Tajik, N., Tajik, M., Mack, I., and Enck, P. (2017). The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature. European Journal of Nutrition, 56(7), 2215-2244. https://doi.org/10.1007/s00394-017-1379-1
Wang, D., Tian, L., Lv, H., Pang, Z., Li, ., Yao, Z., & Wang, S. (2020). Chlorogenic acid prevents acute myocardial infarction in rats by reducing inflammatory damage and oxidative stress. Biomedicine & Pharmacotherapy, 132, 110773. https://doi.org/10.1016/j.biopha.2020.11 07 73
Wang,T., Xu, W-J. Wang, S-X., Kou,P., Wang, P.,Wang; X-Q, Fu, Y-J.(2017). Integrated and sustainable separation of chlorogenic acid from blueberry leaves by deep eutectic solvents coupled with an aqueous two-phase system. food and bioproducts processing, 105, 205–214. https://doi.org/10.1016/j.fbp.2017.07.010
Wu, Y., Wang, Y., Zhang, W., Han, J., Liu, Y., Hu, Y. and Ni, L. (2014). Extraction and preliminary purification of anthocyanins from grape juice in an aqueous two-phase system. Separation and Purification Technology, 124, 170-178. https://doi.org/10.1016/j.seppur.2014.01.025
Yang, Z., Tan, Z., Li, F., Li, X. (2016). An effective method for the extraction and purification of chlorogenic acid from ramie (Boehmeria nivea L.) leaves using acidic ionic liquids. Industrial Crops and Products, 89,78–86. http://dx.doi.org/10.1016/j.indcrop.2016.05.006
Zhang, D. Q., Mu, T. H. and Sun, H. N. (2016). Domestic and abroad research progress of potato tuber-specific storage protein patatin. Sci. Agric. Sin, 49, 1746-1756. http://www.chinaagrisci.com/EN/10.3864/j.issn.0578-175 2.2
André, Ch., Oufir, M., Hoffmann, L., Hausman, J., Rogez, H., Larondelle, Y., Evers, D. (2009). Influence of environment and genotype on polyphenol compounds and in vitro antioxidant capacity of native Andean potatoes (Solanum tuberosum L.). Journal of Food Composition and Analysis, 22, 517-524. https://doi.org/10.1016/j.jfca.2008.11.010
Aydo?an, Ö., Bayraktar, E., Mehmeto?lu, Ü., Kaeding, T. and Zeng, A. P. (2010). Selection and optimization of an aqueous two-phase system for the recovery of 1, 3, propanediol from fermentation broth. Engineering in Life Sciences, 10(2), 121-129. https://doi.org/10.1002/elsc.20 0900084
Bandyopadhyay, G., Biswas, T., Roy, K. C., Mandal, S., Mandal, C., Pal, B. C. and Konar, A. (2004). Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells. Blood, 104(8), 2514-2522. https://doi.org/10.1182/blood-2003-11-4065
Benavides, J. and Rito-Palomares, M. (2008). Aplicación genérica de sistemas de dos fases acuosas polietilenglicol-sal para el desarrollo de procesos de recuperación primaria de compuestos biológicos. Revista Mexicana de Ingeniería Química, 7(2), 99111. http://www.scielo.or g.mx/scielo.php?script=sci_arttext&pid=S166527 382008000200002&lng=es&tlng=es.
Bender, O. and Atalay, A. (2021). Polyphenol chlorogenic acid, antioxidant profile, and breast cancer. In Cancer (pp. 311-321). Academic Press. https://doi.org/10.1016/B978-0-12-819547-5.00028-6
Casas, P. and Daniel, H. (2017). Análisis de las restricciones que influyen en la competitividad de la cadena productiva de papas nativas (Solanum tuberosum) en la región Apurímac. [tesis de bachiller, Universidad Nacional José María Arguedas]. Repositorio Institucional UNAJMA. http://repositorio.unajma.edu.pe/handle/12345 6789/317
Cerón, L. and López, I. (2013). Extracción y cuantificación de compuestos con actividad antioxidante a partir de cáscaras de tres variedades de papa (Solanum tuberosum) en el departamento de Nariño. [Tesis de grado, Universidad de Nariño]. Sistema de Recursos digitales UN. http://sired.udenar.edu.co/2454/
Cheng, Z., Song, H., Cao, X., Shen, Q., Han, D., Zhong, F. and Yang, Y. (2017). Simultaneous extraction and purification of polysaccharides from Gentiana scabra Bunge by microwave-assisted ethanol-salt aqueous two-phase system. Industrial Crops and Products, 102, 75-87. https://doi.org/10.1016/j.indcrop.2017.03.029
Chon, K.Y. and Su-Ling, M. (2021). Effects of recycling on the aqueous two-phase extraction of bioactives from haskap leaves. Separation and Purification Technology, 255, 117755. https://doi.org/10.1016/j.seppur.2020.11 775 5
Cienfuegos, N. E. C., Santos, P. L., García, A. R., Soares, C. M. F., Lima, A. S. and Souza, R. L. (2017). Integrated process for purification of capsaicin using aqueous two-phase systems based on ethanol. Food and Bioproducts Processing, 106, 1-10. https://doi.org/10.101 6/j.fbp.201 7.08.005
Cortés-Burgos, M. P. (2008). Predicción del coeficiente de partición de proteínas en sistemas de dos fases acuosas a través de la caracterización bioinformática de su superficie. [tesis de grado, Universidad de Chile]. Repositorio Institucional UC. http://repositorio.uchile.cl/handle/225 0/1 03095
Dutra-Molino, J., Feitosa, V. A., de Lencastre-Novaes, L. C., Santos-Ebinuma, V., Lopes A. M., Jozala, A. F., Marques D. de A, V., Pellegrini-Malpiedi, L. and Pessoa-Júnior, A. (2014). Biomolecules extracted by ATPS: Practical examples. Revista Mexicana de Ingeniería Química, 13(2), 359-377. https://ri.conicet.gov.ar/handle/11 336/ 12064
Flores, C. F. (2017). Análisis de los factores que inciden en la baja productividad de 5 variedades de papa nativa en la Provincia de Cotabambas, Región Apurímac [tesis de grado, Universidad Nacional de San Agustín]. Repositorio Institucional UNSA. http://repositorio.unsa.edu.pe/handle/UNSA/2725
Gutiérrez, H. and Vara, R. (2012). Análisis y diseño de experimentos, 2. ª ed. Mc Graw Hill, México. https://gc.scalahed.com/recursos/files/r161r/w19537w/analisi s_y_diseno_experimentos.pdf
Huang, A., Deng, W., Wu. D., Wu, S. and Xiao, Y. (2019). Hexafluorisopropanol-salt aqueous two-phase system for extraction and purification of chlorogenic acid from ramie leaves. Journal of Chromatography A, 1597, 196-201. https://doi.org/10.1016/j.chroma.2019.04.046
Iqbal, M., Tao, Y., Xie, S., Zhu, Y., Chen, D., Wang, X. and Hussain, H. I. (2016). Aqueous two-phase system (ATPS): an overview and advances in its applications. Biological procedures online, 18(1), 18. https://doi.or g/10.1186/s12575-016-0048-8
López-Méndez, I. C., Ríos, G. and De Sarón, R. (2014). Determinación del contenido de ácido clorogénico por Espectroscopía UV-VIS en hojas secas y verdes de Cecropia peltata (Guarumo) en árboles silvestres de 10, 15, y 20 M de altura en la reserva natural laguna de apoyo [tesis de doctorado, Universidad Nacional Autónoma de Nicaragua, Managua). Repositorio UNAN. https://repositorio.unan.edu.ni/5369/
Malpiedi, L. P., Nerli, B. B., Abdala, D. S., de Alcântara Pessôa-Filho, P. and Pessoa, A. (2014). Aqueous micellar systems containing Triton X-114 and Pichia pastoris fermentation supernatant: A novel alternative for single chain-antibody fragment purification. Separation and Purification Technology, 132, 295-301. https://doi.org/1 0.1016/j.seppur.2014.05.045
Mariajayaprakash, A., Senthilvelan, T. and Gnanadass, R. (2015). Optimization of process parameters through fuzzy logic and genetic algorithm–A case study in a process industry. Applied Soft Computing, 30, 94-103. https://doi.org/10.1016/j.asoc.2015.01.042
Morales, C. A. D., Medina, S. E. L., Salvatierra, C. R. Z., Barrantes, M. Y. R. and Viera, J. P. H. (2015). Cuantificación de los principios anticancerígenos de la variedad de papa nativa de pulpa de color de la región La Libertad con el fin de procesamiento industrial. Pueblo Continente, 24(2), 425-431. http://journal.upao.edu.pe/Puebl oContinente/article/view/58
Mu, T., Sun, H., Zhang, M. and Wang, C. (2017). Sweet potato processing technology. Academic Press, 7(1),357-403. https://doi.org/10.1016/B978-0-12-812871-8.00001-5
Myers, R ., Montgomery, D., Anderson-Cook (2016)Response Surface Methodology (Process and Product Optimization Using Designed Experiments). Second Edition. John Wiley & Sons.
Narváez-Cuenca, C. E., Vincken, J. P. and Gruppen, H. 2012. Identification and quantification of (dihydro) hydroxycinnamic acids and their conjugates in potato by UHPLC–DAD–ESI-MSn. Food Chemistry, 730-738. https://doi.org/10.1016/j.foodchem.2011.04.050
Naveed, M., Hejazi, V., Abbas, M., Kamboh, A. A., Khan, G. J., Shumzaid, M., ... & XiaoHui, Z. (2018). Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomedicine & Pharmacotherapy, 97, 67-74. https://doi.org/10.1016/j.biopha.2017.10.064
Nemati-Knade, E., Shekaari, H. and Jafari, S. A. (2012). Thermodynamic study of aqueous two-phase systems for some aliphatic alcohols+ sodium thiosulfate+ water. Fluid phase equilibria, 321, 64-72. https://doi.org/10.1016/j.flui d.2012.02.015
Peña, E. F. (2017). Extracción y caracterización fisicoquímica y funcional de almidones de cinco variedades de papas nativas procedentes de Ilave (Puno) [tesis de grado, Universidad Agraria la Molina]. Repositorio Institucional UNALM http://repositorio.lamolina.edu.pe/handle/UN ALM/2655
Rojas-Padilla, C. and Vásquez-Villalobos, V. (2016). Phenolic compounds with antioxidant capacity of the native Andean potato (Solanum tuberosum L.) Huagalina variety in La Libertad-Peru. Scientia Agropecuaria, 7(3), 333-340. http://dx.doi.org/10.17268/sci.agropecu.201 6.0 3.22.
Rojas-Padilla, C, Vásquez-Villalobos, V., Elber, C., Rojas, J. C., Ríos, N. H., Lujan, A. P., Ninaquispe, P. and Espinoza, S. (2018). Phenolic compounds in native potato (Solanum tuberosum L.) cooking water, with potential antioxidant activity. Food Science and Technology, 39 (1), 66-71. https://www.scielo.br/s cielo.php?scrip t=sc i_arttext&pid=S0101-20612019000100066&tl ng=en
Sandoval, M. H., Tenorio-Mucha, J., Tinco-Jayo, A., Loli-Ponce, R. A. and Calderón-Pinillos, S. (2015). Efecto antioxidante y citoprotector del tocosh de Solanum tuberosum papa en la mucosa gástrica de animales de experimentación. In Anales de la Facultad de Medicina, 76(1), 15 - 20. http://dx.doi.org/10.15381/anales.v76i1.11070
Siswanto, F. M., Oguro, A. and Imaoka, S. (2017). Chlorogenic acid modulates hypoxia response of Hep3B cells. Personalized Medicine Universe, 6, 12-16. https://doi.org/10.1016/j.pmu.2017.03.001
Soto-García, M. and Rosales-Castro, M. (2016). Efecto del solvente y de la relación masa/solvente, sobre la extracción de compuestos fenólicos y la capacidad antioxidante de extractos de corteza de Pinus durangensis y Quercus sideroxyla. Maderas. Ciencia y tecnología, 18(4), 701-714. http://dx.doi.org/10.4067/S0718-221X2016 0050 00061
Souza, R. L., Lima, R. A., Coutinho, J. A., Soares, C. M. and Lima, Á. S. (2015). Novel aqueous two-phase systems based on tetrahydrofuran and potassium phosphate buffer for purification of lipase. Process Biochemistry, 50(9),1459-1467. https://doi.org/10.1016/j.procbio.2015.05.01 5
Sukrasno, Y. and Kusmardiyani, S. (2014). Influence of Cooking Methods on Chlorogenic Acid Content of Potato Peels (Solanum tuberosum L.). International Journal of Pharmacognosy and Phytochemical Research, 6(3), 488-491. https://pdfs.semanticscholar.org/626a/eee3249109 23442a5aa2c1a7abe6ede32254.pdf
Tan, Z., Wang, C., Yi, Y., Wang, H., Li, M., Zhou, W. and Li, F. (2014). Extraction and purification of chlorogenic acid from ramie (Boehmeria nivea L. Gaud) leaf using an ethanol/salt aqueous two-phase system. Separation and Purification Technology, 132, 396-400. https://doi.or g/10.1016/j.seppur.2014.05.048
Tajik, N., Tajik, M., Mack, I., and Enck, P. (2017). The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature. European Journal of Nutrition, 56(7), 2215-2244. https://doi.org/10.1007/s00394-017-1379-1
Wang, D., Tian, L., Lv, H., Pang, Z., Li, ., Yao, Z., & Wang, S. (2020). Chlorogenic acid prevents acute myocardial infarction in rats by reducing inflammatory damage and oxidative stress. Biomedicine & Pharmacotherapy, 132, 110773. https://doi.org/10.1016/j.biopha.2020.11 07 73
Wang,T., Xu, W-J. Wang, S-X., Kou,P., Wang, P.,Wang; X-Q, Fu, Y-J.(2017). Integrated and sustainable separation of chlorogenic acid from blueberry leaves by deep eutectic solvents coupled with an aqueous two-phase system. food and bioproducts processing, 105, 205–214. https://doi.org/10.1016/j.fbp.2017.07.010
Wu, Y., Wang, Y., Zhang, W., Han, J., Liu, Y., Hu, Y. and Ni, L. (2014). Extraction and preliminary purification of anthocyanins from grape juice in an aqueous two-phase system. Separation and Purification Technology, 124, 170-178. https://doi.org/10.1016/j.seppur.2014.01.025
Yang, Z., Tan, Z., Li, F., Li, X. (2016). An effective method for the extraction and purification of chlorogenic acid from ramie (Boehmeria nivea L.) leaves using acidic ionic liquids. Industrial Crops and Products, 89,78–86. http://dx.doi.org/10.1016/j.indcrop.2016.05.006
Zhang, D. Q., Mu, T. H. and Sun, H. N. (2016). Domestic and abroad research progress of potato tuber-specific storage protein patatin. Sci. Agric. Sin, 49, 1746-1756. http://www.chinaagrisci.com/EN/10.3864/j.issn.0578-175 2.2
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How to Cite
Optimization with genetic algorithms of chlorogenic acid’s extraction and purification from native potato (Solanum tuberosum L.) peel, using an aqueous two-phase system. (2021). Journal of Applied and Natural Science, 13(1), 377-384. https://doi.org/10.31018/jans.v13i1.2537
