Effect of Piper nigrum (Linn.) seeds extract and second line anti-tuberculosis drugs on a few Mycobacterium tuberculosis strains
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Abstract
Piper nigrum (Linn.) belonging to the family Piperaceae have been reported for its multitudinous medicinal values. The present study was undertaken to examine the direct effect of Ethionamide (ETH), Para amino salicylic acid (PAS), ethanolic extracts of P. nigrum on Mycobacterium tuberculosis (MTB) strain H37Rv and Multi drug-resistant (MDR)-strains-12, 19 and 21. The proportion method was used to detect the anti-mycobacterial drug susceptibility testing for mycobacteria using Lowenstein Jensen (LJ) medium. It was found that P. nigrum does not interfere with single or in the combination of both ETH and PAS showing the bioenhancer activity. In vitro study of ethanolic extract of P. nigrum observed that the extract inhibited the growth of H37Rv strains and MDR strains-12, MDR strains 19, and MDR strains 21. The present results will pave new avenues to find a new medicine that possesses P. nigrum alone or in combination with drugs to combat MDR-strains controlling tuberculosis.
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Keywords
Ethionamide, Mycobacterium tuberculosis, Multidrug-resistant, Para aminosalicyclic acid
References
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Tasduq S A , Kaisar P, Gupta D K, Kapahi B K, Maheshwari H S, Jyotsna S, Johri R K, (2005). Protective effect of a 50% hydroalcoholic fruit extract of Emblica officinalis against anti-tuberculosis drugs induced liver toxicity. Phytother Res., 19 (3),193-7.DOI: 10.1002/ptr.16 31
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Zodape G.V., Gaikwad V.S. (2019). Effect of Piper Nigrum (L.) on Hepatotoxicity Induced by Ethionamide and Para Amino Salicylic Acid in Sprague-Dawley Rats. Biomedical & Pharmacology Journal, 12(3), 1531-1541. DOI : https://dx.doi.org/10.13005/bpj/1784
Barua, C. C., Singh, A., Sen, S,Barua, A. G. and Barua, I. C. (2014). In vitro antioxidant and anti-mycobacterial activity of seeds of Piper longum Linn: A comparative study. SAJ Pharmacy and Pharmacology, 1 (1),1-11.DOI: 10.18875/2375-2262.1.101
Changtam C, Hongmanee P & Suksamrarn A. (2010). Isoxazole analogs of curcuminoids with highly potent multidrug-resistant anti-mycobacterial activity. Eur. J. Med. Chem. 45(10), 4446–4457. DOI: 10.1016/j.ejmech.201 0.07.003
Eman M. Abd El-Kader,Wedad A. Hassan Ekram Nemr Abd Al-Haleem Amany,KA and Yehia A. Raslan. (2018). Curcuma longa and Nigella sativa Modulate the Hepatotoxic Effect of Anti-Tuberculosis Drugs and Acetaminophen in Rats. Journal of Pharmacy and Biological Sciences, 13(3),65-78. DOI: 10.9790/3008-1303016578
Fadipe V. O., Opoku A. R. , Singh M., Pereira A. R., Rijo P. and Mongalo N. I. (2020). Antimycobacterial, antiplasmodial studies and cytotoxicity of oleanolic acid and its derivative from Syzygium aromaticum Linn (Myrtaceae), Biomedical and Biopharmaceutical Research, 17(2), 1-12.
Gruft, H. (1965). Nalidixic acid as a decontaminant in Lowenstein-Jensen medium. J. Bacteriol., 90: (3), 829. DOI: 10.1128/JB.90.3.829-829.1965
Gupta Pooja, Bhatter Purva, D’souza Desiree , Tolani Monica , Daswani Poonam, Pundarikakshudu Tetali & Birdi Tannaz. (2014) Evaluating the anti Mycobacterium tuberculosis activity of Alpinia galanga (L.) Willd. axenically under reducing oxygen conditions and in intracellular assays; BMC Complementary and Alternative Medicine volume 14, Article number: 84, 1-8. DOI: 10.1186/1472-6882-14-84
Gupta, Renu, Thakur, Bandan, Singh, Pushpendra, Singh, H. B., Sharma, V. D., Katoch, V.M. and Chauhan SVS. (2010). Anti-tuberculosis activity of selected medicinal plants against multi-drug resistant Mycobacterium tuberculosis isolates. Indian J. Med. Res., 131,809-13.
NTCP, (2008). Handbook for National Tuberculosis Control Programmes, WHO.
Leon-Diaz R, Meckes M, Said-Fernández S, Molina-Salinas GM, Vargas Villarreal J, Torres J, LunHerrera J, JiménezArellanes A.( 2010). Anti-mycobacterial neolignans isolated from Aristolochia taliscana. Mem Inst. Oswaldo Cruz., 105, 45–51. DOI- https://doi.org/10.11 55/2012/593403.
Mehta A, Srivastva G, Kachhwaha S, Sharma M, Kothari SL.(2013). Anti-mycobacterial activity of Citrullus colocynthis (L.) Schrad. Against drug sensitive and drug resistant Mycobacterium tuberculosis and MOTT clinical isolates. J. Ethnopharmacol., 149(1), 195–200. DOI: 10.1016/j.jep.20 13.06.022
Periyakaruppan Adaikkappan, Manickavasagam Kannapiran, and Arulandhu Anthonisamy (2012). Anti-mycobacterial activity of Withania somnifera and Pueraria tuberosa against Mycobacterium tuberculosis H37Rv. J. Acad. Indus. Res., 1(4), 153-156.
Raviglione MC, Snider DE Jr, Kochi A. (1995). Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic JAMA. 273(3), 220-6.
Singh C,Singh S,Nath G, (2011). Anti-mycobacterial activity of Piper longum L fruit extracts against multi drug resistant spp. International Journal of Phytomedicine, 3(3), 353-361.
Singh R. (2015). A review Medicinal plants. Journal of plant science. 3(1),50-55. DOI: 10.11648/j.jps.s.20150301 01.18
Tasduq S A , Kaisar P, Gupta D K, Kapahi B K, Maheshwari H S, Jyotsna S, Johri R K, (2005). Protective effect of a 50% hydroalcoholic fruit extract of Emblica officinalis against anti-tuberculosis drugs induced liver toxicity. Phytother Res., 19 (3),193-7.DOI: 10.1002/ptr.16 31
WHO Report (2002). Global tuberculosis control, surveillance, planning, finances. World Health Organization, Geneva.WHO document WHO/CDS/TB / 295
WHO (2014). Global Tuberculosis report. World Health Organization (WHO) Geneva: WHO.WHO/HTM/TB/2014.08
WHO (2020). Global Tuberculosis report. World Health Organization, Geneva 2020
Zodape G. V., Bhise P.P. (2017). Effect of Aloe vera Extract and Isoniazid-Rifampicin drug on Mycobacterium tuberculosis bacterial (MTB) strain H37Rv.IJAR, 7(7),144-148. DOI: 10.36106/IJAR
Zodape G.V., Gaikwad V.S. (2019). Effect of Piper Nigrum (L.) on Hepatotoxicity Induced by Ethionamide and Para Amino Salicylic Acid in Sprague-Dawley Rats. Biomedical & Pharmacology Journal, 12(3), 1531-1541. DOI : https://dx.doi.org/10.13005/bpj/1784
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How to Cite
Effect of Piper nigrum (Linn.) seeds extract and second line anti-tuberculosis drugs on a few Mycobacterium tuberculosis strains. (2021). Journal of Applied and Natural Science, 13(1), 402-406. https://doi.org/10.31018/jans.v13i1.2497
