Cholinesterase and microbial inhibitory activities of Tetrapleura tetraptera
##plugins.themes.bootstrap3.article.main##
Abstract
The cholinesterase and microbial inhibitory activities of different parts of Tetrapleura tetraptera plant were evaluated due to their local applications. The cholinesterase results revealed that the extracts showed some levels of inhibitory effects depending on the solvents used. Tetrapleura tetraptera leaves had better inhibitory effects with maximum inhibitory activity of 70.0% at a concentration of 1.00mg/l for the water extract. Tetrapleura tetraptera bark showed highest inhibitory effect of 71.05% and (84.34%) for the ethanol and chloroform extracts at concentrations of 0.5mg/l and 1.0 mg/l respectively. While for petroleum ether, T. tetraptera bark recorded 74.34% inhibitory effect at concentration of 2.0 mg/l and also showed continuous increase in inhibitory activity as the concentration increases for aqueous methanol. The results of the antimicrobial activities showed that among all the test organisms, the
ethanol and water extracts of the leaves, stem, bark and root of the plants had promising activity against Escherichia coli, Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa and Klebsiella pneumonia bacteria and Aspergillus fumigatus and Rhizopus species fungi. There was no activity shown by the ethanol and water extracts of
the parts of the plants with Fugarium oxysporum, Penicillium chrysogenum and Mucor species fungi. The bacteria strains were more sensitive to the tested extracts than the fungi strains.
##plugins.themes.bootstrap3.article.details##
##plugins.themes.bootstrap3.article.details##
Keywords
Anticholinesterase, Antimicrobial, Inhibition, Tetrapleura tetraptera
References
Adesina, S. K. (1982). Studies in Nigerian herbal Anticonvulsant recipe. International Journal of Crude Drug. Reversed Edition Vol. 20 (2): 93-100.
Adesina, S. K., Adewunmi, C. O. and Marquis, V. O. (1980). Phytochemical investigation of the mullusicidal properties of Tetrplueura tetraptera (Taub). Journal of African Medical Plants, 3: 7-15.
Adewunmi, C. O., Gebremedhin, G., Becker, W., Olorunmola, F. O., Dorfler, G. and Adewunmi, T. A. (1993). Schistosomiasis and intestinal parasites in rural villages in south west Nigeria: an indication for expanded programme on drug distribution and integrated control programme in Nigeria”. Trop. Med. Parasitol., 44: 177-180.
Ahmad, I., Anis, I., Malik, A., Nawaz, S. A. and Choudhary, M. I. (2003). Cholinesterase inhibitory constituents from Onosma hispida. Chem. Pharm. Bull., 51(4): 412-414.
Akobundu, I. O. and Agyakwa, C. W. (1998). A Handbook of West Africa Weeds. (2nd edition). International Institute of Tropical Agriculture, Ibadan. p. 418.
Bode, A. U., Adewunmi, C. O., Dorfler, G. and Becker, W. (1996). The effect of extracrs from Tetrapleura tetraptera and Baylucide on cell tissue structure of Biomuphalaria Glabrata. Journal of Ethrophamarcology,50(2): 103.
Chandra, R. and Sarbhoy, A. K. (1997). Production of aflatoxins and zearalenone by the toxigenic fungal isolates obtained from stored food grains of commercial crops. Indian Phytopathology, 50: 458-68.
Irvine, F. R. (1961). Wooden Plants of Ghana with Special References to their Uses. London: Oxford University Press.
Janardhana, G. R., Raveesha, K.A. and Shetty, H.S. (1998). Modified atmosphere storage to prevent mould-induced nutritional loss in maize. Journal of Science Food and Agriculture, 76: 573-578.
Janardhana, G. R., Raveesha, K. A. and Shetty, H. S. (1999). Mycotoxin contamination of maize grains grown in Karnataka (India). Food Chemical Toxicology, 37: 863- 868.
JohnBull, E. O. and Muluh, E. K. (2009). Phytochemical analysis and ChE inhibition of Cyperus platycaulis. The Pacific Journal of Science and Technology, 10(1): 350-356
JohnBull, E. O. and Abdu, K. (2006a). Phytochemical and antimicrobial screening of ethanol extracts of the leaves of Anogeissus leiocarpus. Biol. & Environ. Science J. for the Tropics, 3 (3): 162-164.
JohnBull, E. O. and Abdu, K. (2006b). Screening of the extracts of Anogeissus leiocarpus for antituberculosis against: The enzyme estuation approach. A paper presented at the 20th Annual International Conference of Chemistry Society of Nigeria on Chemistry and Global Development Environmental Concern, Lagos, September.
JohnBull, E. O. and Afolabi, S. O. (2001). Bioctive evaluation of extracts of euphorbia hirta: The anti microbial and anticholinesterase approach. J. Phytomedicine and Theapeutics, 6(2): 79–84.
JohnBull, E. O., Ali, J., Abdulahi, S., Mustapha, A. D., Dele, R., Musa, K., Aminu, M. H. and Sylvester, M. (2001). Exploration of extracts of some Nigerian medicinal plants- The anti microbial and anticholinesterase approach. Indian. Chem. Biol., 5: 41-45.
Keay, R. W. and Onochie, C. E. (1964). Nigerian Trees. Federal Department of Forest Research. Ibadan.
Koelle, G. B. (1975). Drugs acting at synaptic and neuro effect or functional sites. In Goodman L. S., Gilman A. (Eds.) The Pharmacological basis of therapeutics. 5th edition. New York: Macmillian Pub. Co. Inc., 404 -476.
Koirala, P., Kumar, S., Yadar, B. K. and Premarajan, K. C. (2005). Occurrence of aflatoxin in some of the food and feed in Nepal. Indian Journal of Medical Sciences, 59: 331-336.
Lester, H. A. (1977). The response to acetylcholine. Sci. Am., 236: 106-118.
Marin. S., Homedes, V.,Sanchis, V., Ramos, A. J. and Magan, N. (1999). Impact of Fusarium moniliforme and F. proliferatum colonisation of maize on calorific losses and fumonisin production under different environmental conditions. Journal of Stored Product Research, 35: 15-26.
Nwaiwu, J. I. and Akah, P. A. (1986). Anticonstustant activity of the volatile oil from the fruit of Tetrapluera tetraptera. Journal of Ethnopharmacology, 8: 1-93.
Oliver-Bever, B. (1986). Medicinal Plants of Tropical West Africa. London: Cambridge University Press.
Okochi, V. I., Gbenie, G. O., Kazeem, A. A., Fagbenro-Bayioku, A. F., Igbodudu, H. E. and Anikwe, U. (1999). Effect of water extract of Tetrapleura tetraptera on Haematological Brucei. Nig. Quarterly J. Hospital Med.,9 (1): 66 – 70.
Okwu, D. E. and Ekeke, O. (2003). Phytochemical screening and mineral composition of chewing sticks in South Eastern Nigeria. Global Journal of Pure and Applied Sciences, 455 – 459.
Orhan, I., Sener, B., Choudhary, M. I. and Khalid, A. (2004). Acetyl cholinesterase and butrylcholinesterase inhibitory activity of some Turkish medicinal plants. J. Ethnopharmacol., 91: 57-60.
Ortega, M. G.., Agnese, A. M. and Cabrera, J.L. (2004). Anticholinesterase activity in an alkaloid extracts of Huperzia saururus. Phytomedicine, 11: 539-543.
Rajakaruna, N., Harris, C. S. and Towers, G. H. N. (2002). Antimicrobial activity of plants from Serpentine outcrops in Sri Lanka. Pharmaceutical Biology, 235-244.
Rafeeq, A. K., Ishfaq, A. B., Sarfraz; A. N. and Muhammad, I. C. (2006). Acetylcholinesterase and Butyrylcholinesterase inhibitory potential of some Pakistani medicinal plants. Journal of Applied Science, 2 (1).
Sung, H. S., Kang, S. Y., Lee, K. Y., Park, M. J., Kim, J. H., Park, J. H., Kim, Y. C., Kim, J. and Kim, Y. C. (2002). (+)Vineferin, a stilbene trimer from Caragana chamlague, inhibits acteylcholinesterase. Biol.Pharm. Bull., 25(1): 125-127.
Valsaraji, R., Pushpangadan, P., Smith, U. W., Adsergen A. and Nyman, U. (1997). Antimicrobial screening of selected medicinal plants from India. Journal of Ethnopharmacology, 58: 75-83.
Viegas, C. Jr., Bolzani, V. S., Pimentel, L. S., Castro, N. G.., Cabral, R. F., Costa, R. S., Floyd, C., Rocha, M. S., Young, M. C., Barreiro, E. J. and Fraga, C. A. (2005). New selective acetyl cholinesterase inhibitors designed from natural piperidine alkaloids. Bioorg Med Chem., 13: 4184-4190.
Adesina, S. K., Adewunmi, C. O. and Marquis, V. O. (1980). Phytochemical investigation of the mullusicidal properties of Tetrplueura tetraptera (Taub). Journal of African Medical Plants, 3: 7-15.
Adewunmi, C. O., Gebremedhin, G., Becker, W., Olorunmola, F. O., Dorfler, G. and Adewunmi, T. A. (1993). Schistosomiasis and intestinal parasites in rural villages in south west Nigeria: an indication for expanded programme on drug distribution and integrated control programme in Nigeria”. Trop. Med. Parasitol., 44: 177-180.
Ahmad, I., Anis, I., Malik, A., Nawaz, S. A. and Choudhary, M. I. (2003). Cholinesterase inhibitory constituents from Onosma hispida. Chem. Pharm. Bull., 51(4): 412-414.
Akobundu, I. O. and Agyakwa, C. W. (1998). A Handbook of West Africa Weeds. (2nd edition). International Institute of Tropical Agriculture, Ibadan. p. 418.
Bode, A. U., Adewunmi, C. O., Dorfler, G. and Becker, W. (1996). The effect of extracrs from Tetrapleura tetraptera and Baylucide on cell tissue structure of Biomuphalaria Glabrata. Journal of Ethrophamarcology,50(2): 103.
Chandra, R. and Sarbhoy, A. K. (1997). Production of aflatoxins and zearalenone by the toxigenic fungal isolates obtained from stored food grains of commercial crops. Indian Phytopathology, 50: 458-68.
Irvine, F. R. (1961). Wooden Plants of Ghana with Special References to their Uses. London: Oxford University Press.
Janardhana, G. R., Raveesha, K.A. and Shetty, H.S. (1998). Modified atmosphere storage to prevent mould-induced nutritional loss in maize. Journal of Science Food and Agriculture, 76: 573-578.
Janardhana, G. R., Raveesha, K. A. and Shetty, H. S. (1999). Mycotoxin contamination of maize grains grown in Karnataka (India). Food Chemical Toxicology, 37: 863- 868.
JohnBull, E. O. and Muluh, E. K. (2009). Phytochemical analysis and ChE inhibition of Cyperus platycaulis. The Pacific Journal of Science and Technology, 10(1): 350-356
JohnBull, E. O. and Abdu, K. (2006a). Phytochemical and antimicrobial screening of ethanol extracts of the leaves of Anogeissus leiocarpus. Biol. & Environ. Science J. for the Tropics, 3 (3): 162-164.
JohnBull, E. O. and Abdu, K. (2006b). Screening of the extracts of Anogeissus leiocarpus for antituberculosis against: The enzyme estuation approach. A paper presented at the 20th Annual International Conference of Chemistry Society of Nigeria on Chemistry and Global Development Environmental Concern, Lagos, September.
JohnBull, E. O. and Afolabi, S. O. (2001). Bioctive evaluation of extracts of euphorbia hirta: The anti microbial and anticholinesterase approach. J. Phytomedicine and Theapeutics, 6(2): 79–84.
JohnBull, E. O., Ali, J., Abdulahi, S., Mustapha, A. D., Dele, R., Musa, K., Aminu, M. H. and Sylvester, M. (2001). Exploration of extracts of some Nigerian medicinal plants- The anti microbial and anticholinesterase approach. Indian. Chem. Biol., 5: 41-45.
Keay, R. W. and Onochie, C. E. (1964). Nigerian Trees. Federal Department of Forest Research. Ibadan.
Koelle, G. B. (1975). Drugs acting at synaptic and neuro effect or functional sites. In Goodman L. S., Gilman A. (Eds.) The Pharmacological basis of therapeutics. 5th edition. New York: Macmillian Pub. Co. Inc., 404 -476.
Koirala, P., Kumar, S., Yadar, B. K. and Premarajan, K. C. (2005). Occurrence of aflatoxin in some of the food and feed in Nepal. Indian Journal of Medical Sciences, 59: 331-336.
Lester, H. A. (1977). The response to acetylcholine. Sci. Am., 236: 106-118.
Marin. S., Homedes, V.,Sanchis, V., Ramos, A. J. and Magan, N. (1999). Impact of Fusarium moniliforme and F. proliferatum colonisation of maize on calorific losses and fumonisin production under different environmental conditions. Journal of Stored Product Research, 35: 15-26.
Nwaiwu, J. I. and Akah, P. A. (1986). Anticonstustant activity of the volatile oil from the fruit of Tetrapluera tetraptera. Journal of Ethnopharmacology, 8: 1-93.
Oliver-Bever, B. (1986). Medicinal Plants of Tropical West Africa. London: Cambridge University Press.
Okochi, V. I., Gbenie, G. O., Kazeem, A. A., Fagbenro-Bayioku, A. F., Igbodudu, H. E. and Anikwe, U. (1999). Effect of water extract of Tetrapleura tetraptera on Haematological Brucei. Nig. Quarterly J. Hospital Med.,9 (1): 66 – 70.
Okwu, D. E. and Ekeke, O. (2003). Phytochemical screening and mineral composition of chewing sticks in South Eastern Nigeria. Global Journal of Pure and Applied Sciences, 455 – 459.
Orhan, I., Sener, B., Choudhary, M. I. and Khalid, A. (2004). Acetyl cholinesterase and butrylcholinesterase inhibitory activity of some Turkish medicinal plants. J. Ethnopharmacol., 91: 57-60.
Ortega, M. G.., Agnese, A. M. and Cabrera, J.L. (2004). Anticholinesterase activity in an alkaloid extracts of Huperzia saururus. Phytomedicine, 11: 539-543.
Rajakaruna, N., Harris, C. S. and Towers, G. H. N. (2002). Antimicrobial activity of plants from Serpentine outcrops in Sri Lanka. Pharmaceutical Biology, 235-244.
Rafeeq, A. K., Ishfaq, A. B., Sarfraz; A. N. and Muhammad, I. C. (2006). Acetylcholinesterase and Butyrylcholinesterase inhibitory potential of some Pakistani medicinal plants. Journal of Applied Science, 2 (1).
Sung, H. S., Kang, S. Y., Lee, K. Y., Park, M. J., Kim, J. H., Park, J. H., Kim, Y. C., Kim, J. and Kim, Y. C. (2002). (+)Vineferin, a stilbene trimer from Caragana chamlague, inhibits acteylcholinesterase. Biol.Pharm. Bull., 25(1): 125-127.
Valsaraji, R., Pushpangadan, P., Smith, U. W., Adsergen A. and Nyman, U. (1997). Antimicrobial screening of selected medicinal plants from India. Journal of Ethnopharmacology, 58: 75-83.
Viegas, C. Jr., Bolzani, V. S., Pimentel, L. S., Castro, N. G.., Cabral, R. F., Costa, R. S., Floyd, C., Rocha, M. S., Young, M. C., Barreiro, E. J. and Fraga, C. A. (2005). New selective acetyl cholinesterase inhibitors designed from natural piperidine alkaloids. Bioorg Med Chem., 13: 4184-4190.
Issue
Section
Research Articles
This work is licensed under Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) © Author (s)
How to Cite
Cholinesterase and microbial inhibitory activities of Tetrapleura tetraptera. (2012). Journal of Applied and Natural Science, 4(2), 156-163. https://doi.org/10.31018/jans.v4i2.240
