Efficacy of vitamin E and vitamin C against silica induced toxicity on male reproductive organs of albino rats
##plugins.themes.bootstrap3.article.main##
Abstract
Silica is one of the most documented workplace contaminants. Long-term occupational exposure to silica is associated with an increased risk in respiratory diseases such as silicosis, tuberculosis, chronic bronchitis, chronic obstructive pulmonary disease and lung cancer. The present study was carried out to observe the alteration in testosterone level & histopathological changes in the testis and epididymis after silica exposure, and to show whether therapeutic agents (Vitamin E + Vitamin C) used in study may provide recovery against exposure to silica. For investigations, silica was administered in albino rats as silicon dioxide at a dose of 40 mg/Kg for 28 days (IP) to produce toxic effects. Recovery pattern was evaluated by Vitamin E + vitamin C (50 mg/kg, ip + 100 mg/kg, po, for 5 days after silica administration. The study showed alterations in the various blood parameters after intraperitoneal
intoxication of silicon dioxide. Testosterone was significantly decreased in experimental rats after 28 days of silica intoxication. Therapeutic agents i.e. vitamin E and vitamin C recouped the values to normal control and recoupment was also observed in histology of testis and epididymis.
##plugins.themes.bootstrap3.article.details##
##plugins.themes.bootstrap3.article.details##
Blood parameters, Intraperitoneal, Silicon di-oxide, Testosterone, Therapeutic agents
Dorfman, R. I., forcheilli, E. and Gut, M. (1963). Androgen biosynthesis and related studies. Recent Prog. Horm. Res., 19: 251-273.
Fatma, S. K., Prabhavathi, P. A., Padmavathis, P. and. Reddy, P. P. (2001). Analysis of Chromosamal aberrations in men occupationally exposed to cement dust. Mutational Res., 490: 179-186.
Hnizdo, E. (1990). Combined effect of silica dust and tobacco smoking on mortality from chronic obstructive lung disease in gold minters. Br. J. Ind. Med., 47: 656.
Hnizdo, E. and Sluis-Cremer, G. K. (1991). Silica exposure, silicosis and lung cancer: A mortality study of south African gold miners. Br. J. Ind. Med., 48:53.
ICMR Bulletin (1999). Silicosis- an uncommonly diagnosed common occupational disease. Div. of Publ. and Inform. 29, 9.
Jacob, D., Yadava, L. and Vyas, D. K. (1988). Alternation in PO4 contents of genital organs of male rats after administration of antifertility doses of Plumeria leaf. J. Adv. Zoo., 9 (1): 6-10.
Jaffrey, L. L., O’Sullivan, M. F., Corn, C. J., Williams, M. G. and Dodson, R. F. (1999). Asbestosis and small lung cancer in a clutch refabricator. Occup. Environ. Med., 56: 602.
John, S., Kale, M., Rathore, N. and Bhatnagar, D. (2001). Protective effect of vitamin E in dimethoate and malathione induced oxidative stress in rat erythrocytes. J. Nutr. Biochem., 12: 500.
Joseph, D. (1994). Global warming impact on the cement and aggregate industries. Geopolymer Institute Saint- Quention, France. World Resour. Rev., 6: 263-278.
Karnik, A. B. Saiyed, H. N. and Nigam, S. K. (1990). Humoral immunologic dysfunction in silicosis. Ind. J. Med. Res. [B] 92:440.
Kaur, P., Kullar, O. M., Mittal, S. and Rai, U. C. (1988). Effects of Gossypal on testes and epididymis of Albino rats. Indian J. Med. Res., 87 (4): 368-378.
Magnani, C., Mollo, F., Paoletti, L., Bellis, D., Bernardi, P., Betta, P., Botta, M., Falchi, M., Ivaldi, C. and Pavesi, M. (1998). Asbestos lung burden and asbestosis after occupational and environmental exposure in an asbestos cement manufacturing area: a necropsy study. Occup. Environ. Med., 55: 840.
Malmberg, P., Hedenstrom, H. and Sundblad, B. M. (1993). Changes in lung function of granite crushers exposed to moderately high silica concentrations: A 12-year follow-Up. Br. J. Ind. Med., 50:726.
Mohallem, S.V. D. J. De Araujo. Lobo, C. R. Pesquero, J. V. Assuncao, P. A. Andre, P. H. Nasinento, S. and Dolhnikoff, M. (2005). Decreased fertility in mice exposed to environmental air pollution in the city of Sao Paulo. Environ. Res., 98: 196-202.
Nigragau, J. O. and Davidson, C. L. (1986). Toxic Metals in the Atmosphere.John Wiley and Sons, New York. Occupational Hygiene, 43 (4):269-273
Oleru, U. G. (1984). Pulmonary function and symptoms of Nigerian workers exposed to cement dust. Environmental Research , 33(2): 379-385.
Paul, H. E.; Paul, M. F.; Kopko, F.; Bender, R. C. and Everett, G. (1953). Crbohydrate metabolism studies on the testis of rat for certain nitrofurans. Endocrinology, 53: 585-588.
Selevan, S. G. L. Borkovek, V. L. Slott, Z. Zudova, J. Rubea, D. P. Evenson and Perreault, S. D. (2000). Semen quality and reproductive health of young Czech men exposed to seasonal air pollution. Environ.Health Perspect.,108:887-894.
Stoyanovsky, D., Goldman, R., Darrow, R., Organisciak, D. and Kagan, V. (1995). Endogenous ascorbate regenerates vitamin E in the retina directly and in combination with dihydrolipoic acid. Curr. Eye. Res., 14:181.
Vanessa, V. Barrett, C. Roycroft, J. Schuman, L. Dankovic, D. Baron, P. Martomen, T. Papelko, W. and Lai, D. (1996). Workshop Report. Chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles. Regul. Toxicol. and Pharmacol., 24: 202.
Weiss, W. (2000). Asbestosis and lober site of lung cancer. Occup. Environ. Med., 57:358.
Wilson, R.. Langer, A. M. Nolan, R. P. Barnard, J. Gee, L. and Ross, M. (1994). Asbestos in New York city public school buildings- public policy: is there a scientific basis? Reg. Toxicol. and Pharmacol., 20: 161.
Yucesoy, B., Vallyathan, V., Landsittel, D. P., Sharp, D. S., Wewton, A., Burleson, G. R., Simionova, P., McKinstry, M. Luster, M. I. (2001). Association of tumor necrosis factor- á and interleukin-1 gene polymorphism with silicosis. Toxicol. and appl. Pharmacol., 172: 75.
This work is licensed under Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) © Author (s)