Enteric diseases enter through the mouth and are usually spread by contaminated food, water or contact with contaminated vomit or feces. Enteric infection encompasses all the infections of the intestinal tract. These intestinal infections include organisms like Escherichia coli, Salmonella, Shigella, Klebsiella, Proteus etc. Out of these, E. coli are one of the common causes of enteric infection. In spite the introduction of a wide variety of antimicrobial agents against enteric diseases, life threatening infections caused by E. coli contributes to morbidity and mortality in patients. The present study was conducted to determine the antibiotic sensitivity pattern of E. coli obtained from stool samples and potentiation of antibiotic activity by citric acid against multiple drug resistant E. coli. Out of the 200 isolates of E. coli, 150 were found to be resistant to one or more antibiotics tested. 0.05% and 0.1% citric acid was found to be effective in increasing the potency of the all the antibiotics used in the study.
Antimicrobial, Enteric, Escherichia, Potentiation, Potency, Resistance
Bureau of Epidemiology. (2004).â€˜Situation of diarrheal diseasesâ€™. Bangkok: Department of Disease Control, Ministry of Public Health.
Fang, T.J., Wei, Q.K., Liao, C.W., Hung, M.J. and Wang, T.H. (2003). Microbiological quality of 18 degrees C ready- toeat food products sold in Taiwan. Int. J. Food Microbiol., 80: 241-50.
Gomashe, A.V. and Tumane, P.M. (2006). In vitro antimicrobial activity of citric acid against multidrug resistant uropathogens. J. of Curr. Sci., 9 (2) 595-598.
Jay, J.M., (2000). Modern food Microbiology 6th Edition. Aspen Publishers. Gaithersburg Maryland.
Jones, R.N. and Thornsberry, C. (1982). Cefotaxime: a review of in vitro antimicrobial properties and spectrum of activity. Rev. Infect Dis., 4: 5300-15.
Mosbyâ€™s Medical Dictionary. (2009). 8th Edition, Elsevier.
Nagoba, B.S., Wadher, B. J. and Chandorkar, A.G. (2002). Citric acid treatment of non-healthy ulcers in leprosy patients. Brit. J. Dermato, 146: 1101.
Nagoba, B.S., Wadher, B. J., Rao, A.K., Kore, G.D., Gomashe, A.V. and Ingle, A.B. (2008). A simple and effective approach for the treatment of chronic wound infections caused by multiple antibiotic resistant E.coli. Journal of Hospital Infection, 69: 177-180.
Tumane, P. M., Wadher, B. J., Aqueel, Khan and Ashok V. Gomashe (2006). Antimicrobial activity of citrus fruit juices. J.Curr. Sci., 9(1): 89-94.
Rabbani, G. H. and Greenough, W. B. (1999). â€˜Food as a vehicle of transmission of choleraâ€™. J Diarrhoeal Dis Res., 17: 1-9
Russell, A. D. and Furr, J. R. and Pugh, W. J. (1986). Sequential loss of outer membrane lipopolysaccharide and sensitivity of E.coli to antibacterial agents. International Journal of Pharmaceutics, 35: 227-233.
WHO (2001). Model Prescribing Information: drugs used in Bacterial infections. World Health Organization-Report.
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