D. M. Agase S. B. Zade M. S. Markam P.M. Mohurle P.R. Chaudhari S.P. Padole P.R. Bandebuche P.D. Bhoyar A.D. Pangal A.K. Ganju


A combination of haematological parameters with morphological evaluation of peripheral blood and bone marrow blast cells is crucial for leukaemia diagnosis. FAB (French– American–British) classification is a simple and powerful diagnostic tool for leukaemia           in developing countries like India. Differentiation block in the early stages of haematopoiesis and morphological characteristics of leukemic blast cells are directly related to haematological parameters. The present study is an approach to increase understanding of the simple morphological FAB classification of leukaemia  in relation to haematological parameters. The present study revealed that Chronic Myeloid Leukaemia  (CML) was the most common type of leukaemia , followed by Acute Myeloid Leukaemia, Acute Lymphoid Leukaemia  (ALL), and Chronic Lymphoid Leukaemia  (CLL) in Nagpur. Most of the cases of Acute Leukaemia  had severe anaemia and thrombocytopenia. Highest variation was found in Total WBCs count of different types of leukaemia , particularly in different subtypes of AML. The present study also suggested that FAB classification is not outdated, but it does require continuous revalidation and other procedures for refinement.           


Download data is not yet available.


Metrics Loading ...




Blast cell, Bone marrow, FAB classification, Haematopoiesis, Leukaemia

Ahirwar R, Nigam R. K, Parmar D. (2018). A study of leukaemia’s profile in central India. Tropical Journal of Pathology & Microbiology, 4(2), Print ISSN: 2456-9887, Online ISSN: 2456-1487.
Baviskar J. (2016). Incidence of acute and chronic leukaemia s in rural area at tertiary care teaching hospital: A five years of study. Indian Journal of Pathology and Oncology, 3(4), 710-713.
Bennett JM, Catovsky D, Daniel M?T, Flandrin G, Galton D. A. G, Gralnick H. R, Sultan C. (1976). Proposals for the classification of the acute leukaemias. British Journal of Haematology, 33(4), 451-458.
Chatterjea JB, Ghose S, Ray RN. (1962). Incidence of leukaemia. (An analysis of 544 cases studied in Calcutta). The Journal of the Association of Physicians of India, 10, 673-6.
Conter V, Rizzari C, Sala A, Chiesa R, Citterio M, Biondi A. (2004). Acute Lymphoblastic Leukaemia . Orphanet Encyclopedia.
Danielle E. W, Ling Z, Sophie S, Stephen L. (2008). Concurrent Megakaryocytic and Erythroid Chronic Myelogenous Leukaemia Blast Crisis. Arch Pathol Lab Med, 132, 1021–1025.
David O, Monica E, Estella M, Ricardo M, Jonathan C. Strefford, Daniel C. (2016). The morphology of CLL revisited: the clinical significance of prolymphocytes and correlations with prognostic/molecular markers in the LRF CLL4 trial. British Journal of Haematology, 174, 767–775.
Fasakin KA, Okogun GR, Omisakin CT, Adeyemi AA, Esan AJ. (2014). Modified Leishman Stain: The Mystery Unfolds. British Journal of Medicine & Medical Research, 4(27), 4591- 4606.
Farzana C, Tahir S, Shamsi, Ali M. W. (2016). Clinical and Haematological Profile of Acute Myeloid Leukaemia (AML) Patients of Sindh. Journal of Hematology & Thromboembolic Diseases, 4(2), 239.
Gaydos LA, Freireich EJ, Mantel N. (1962), The quantitative relation between platelet count and hemorrhage in patients with acute leukaemia . N Engl J Med, 266, 905-909.
Ghosh SC, Shinde SC, Kumaran GS, Sapre RS, Dhond SR, Badrinath Y, Ansari R, Kumar A, Mahadik S, Chaugule AB, Nair CN. (2003). Hematologic and Immunophenotypic Profile of Acute Myeloid Leukaemia : An Experience of Tata Memorial Hospital. Indian J Cancer, 40(2), 71-76.
Gunz FW. (1977). The epidemiology and genetics of the chronic leukaemias. Clinics In Haematol, 6(1), 3-20.
Karl G, Daniel A. (2000). Chronic myelogenous leukaemia . Laboratory medicine, 31, 10.
Ladines-Castro W, Barragán-Iba˜nez G, Luna-Pérez M.A, Santoyo-Sánchez A, Collazo-Jaloma J, Mendoza-García E, Ramos-Pe˜nafiel C.O. (2016), Morphology of Leukaemia s. Rev Med Hosp Gen Mex, 79(2), 107-113.
Prakash S, Ramamurthi, Gopalan R, Aurora AL. (1981). Leukaemias at Pondicherry. Indian J Cancer, 18 (1), 1-6.
Qazi R, Hameed B. (2002). Bleeding diathesis in acute Myeloid Leukaemia : Thrombocytopenia alone or in Disseminated Intravascular Coagulopathy. Pak J Med Sci, 13, 682-685.
Radha R, Minakshi V, Ashok K, Sunita S. (2014). Incidence of acute and chronic forms of leukaemia in Haryana; International Journal of Pharmacy and Pharmaceutical Sciences, 6(2), 42- 45.
Rani S, Beohar PC, Mohanty TK, Mathur MD. (1982). Leukaemic pattern in Delhi--a ten-year study of 490 cases. Indian J Cancer, 19(2), 81- 6.
Sabina C, Gina Z, Renato B. (2014). Diagnosis and Sub classification of Acute Lymphoblastic Leukaemia . The Mediterranean Journal of Hematology and Infectious Diseases, 6(1), e2014073.
Sareen R, Kapil M, Gupta GN. (2018). Incubation and its effect on Leishman stain. J Lab Physicians, 10(03), 357-361.
Sharma S, Nangia N, Jain S, Narayan S, Harbhajanka A, Singh S. (2009). Clinico Haematological Profile of Acute Megakaryoblastic Leukaemia: Report of Five Cases. Adv Hematol, 10, 673-6.
Singh T. (2018). Atlas and text of Hematology. Avi. Pub, 4 (1), 237-314.
Varghese PR, Elayidom NB, Joseph CD, Kumar S. (1984). Epidemiological observations on leukaemia in Kerala (A study of 1016 cases over three years), Ind J Haemato, 2, 15-17.
Vasavada PS, Akbar Ali, Mukherjee DP. (1962). Clinical studies in leukaemia - A review of 100 cases in symposium in Leukaemia . Leukaemia Journal of associations Phy India, 9, 357.
Citation Format
How to Cite
Agase, D. M., Zade , S. B., Markam, M. S., Mohurle, P. ., Chaudhari, P. ., Padole, S. ., Bandebuche, P. ., Bhoyar, P. ., Pangal, A., & Ganju, A. . (2020). Studies on the morphology of leukaemic blast cells in relation to haematological parameters . Journal of Applied and Natural Science, 12(2), 171–179. https://doi.org/10.31018/jans.vi.2267
More Citation Formats:
Research Articles

Most read articles by the same author(s)