he present work has been taken to assess the pharmacological efficacy of two edible macrofungi Dacryopinax spathularia and Schizophyllum commune in the improvement of renal profile of Gentamicin-induced nephrotoxicity in albino wistar rats. The intra-peritoneal administration of gentamicin 80 mg/Kg Body Weight per day had resulted in alterations in renal function and renal damage which was reflected by abnormal and significant (p=0.05) increase in renal function parameters of blood like Urea, Creatinine, Uric Acid and Blood Urea Nitrogen (BUN). On administration of high dose (500 mg/Kg BW) of D. Spathularia extract to the nephrotoxic group of rats the concentration of urea, creatinine, uric acid and BUN significantly decreased from 104.26±7.45 to 76.27±7.24, 1.17±0.43 to 0.68±0.47, 3.68±1.34 to 2.58±0.56 and 48.72±4.36 to 31.14±3.76 respectively, in comparison to the nephrotoxic group of rats. On the other hand, the administration of high dose (500 mg/Kg BW) of S. commune extract to the nephrotoxic group of rats resulted into significant (p=0.05) decrease in the concentration of urea, creatinine, uric acid and BUN, from 104.26±7.45 to 51.42±6.15, 1.17±0.43 to 0.62±0.14, 3.68±1.34 to 2.36±0.74 and 48.72±4.36 to 28.65±3.85 respectively, in comparison to the nephrotoxic group of rats. The results also revealed that S. commune extract showed comparatively more efficacy in the renal profile improvement of nephrotoxic rats in comparison to the D. spathularia extract.
Dacryopinax spathularia, Gentamicin, Macrofungi, Nephrotoxicity, Oxidative stress, Schizophyllum commune
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