he present work has been taken to assess the pharmacological efficacy of two edible macrofungi Dacryopinax spathularia and Schizophyllum commune in the improvement of renal profile of Gentamicin-induced nephrotoxicity in albino wistar rats. The intra-peritoneal administration of gentamicin 80 mg/Kg Body Weight per day had resulted in alterations in renal function and renal damage which was reflected by abnormal and significant (p=0.05) increase in renal function parameters of blood like Urea, Creatinine, Uric Acid and Blood Urea Nitrogen (BUN). On administration of high dose (500 mg/Kg BW) of D. Spathularia extract to the nephrotoxic group of rats the concentration of urea, creatinine, uric acid and BUN significantly decreased from 104.26±7.45 to 76.27±7.24, 1.17±0.43 to 0.68±0.47, 3.68±1.34 to 2.58±0.56 and 48.72±4.36 to 31.14±3.76 respectively, in comparison to the nephrotoxic group of rats. On the other hand, the administration of high dose (500 mg/Kg BW) of S. commune extract to the nephrotoxic group of rats resulted into significant (p=0.05) decrease in the concentration of urea, creatinine, uric acid and BUN, from 104.26±7.45 to 51.42±6.15, 1.17±0.43 to 0.62±0.14, 3.68±1.34 to 2.36±0.74 and 48.72±4.36 to 28.65±3.85 respectively, in comparison to the nephrotoxic group of rats. The results also revealed that S. commune extract showed comparatively more efficacy in the renal profile improvement of nephrotoxic rats in comparison to the D. spathularia extract.
Dacryopinax spathularia, Gentamicin, Macrofungi, Nephrotoxicity, Oxidative stress, Schizophyllum commune
Arivazhagan, S.J.J., Vimaastalin, R. (2014). Nephroprotective activity of Aristo lochia Indica leaf extract against gentamicin induced renal dysfunction. International Journal of Research in Biochemistry and Biophysics; 4(2):13-8.
Balakumar, P., Chakkarwar, V.A., Kumar, V., Jain, A., Reddy, J., Singh, M. (2008). Experimental models for nephropathy. J Renin Angiotensin Aldosterone Syst; 9(4):189-95.
Cuzzocrea, S., Mazzon, E., Dugo, L., Serraino, I., Di-Paola, R., Britti, D., et al. (2002). A role for superoxide in gentamicin-mediated nephropathy in rats. Eur J Pharmacology; 450(1):67-76.
Erdem, A., Gundogan, N., Alp, U., and Kara, A. (2000). The protective effect of taurine against Gen.-induced acute tubular necrosis in rats. Nephrol Dial.Transplant, 15:1175-82.
Gilbert, D.N. (2005) Aminoglycosides. In: Mandell GL, Bennett JE, Dolin R, editors. Principle and practices of infectious disease. 6th ed. New York: Churchill Livingstone; p. 328.
Harlalka, G.V., Patil, C.R., Patil, M.R. (2007). Protective effects of Kalanchoe pinnata pers. (Crassulaceae) on gentamicin-induced nephrotoxicity in rats. Indian J Pharmacol; 39(4):201-5.
Kumar, A., Ali, S., Lal, S.B., Sinha, M.P. (2018). Mycochemical screening and determination of nutritive potency and antioxidant activity of edible macrofungi Dacryopinax spathularia and Schizophyllim commune. World J. of Pharm. Res., Vol. 7, Issue 16, 1311-1321.
Kumar, A., Kumar, M., Sinha, M.P. (2019). Hepatoprotective efficacy of edible macrofungi Dacryopinax spathularia (Scwein) and Schizophyllum commune (Fries) against Carbon tetrachloride induced hepatotoxicity in albino Wistar rats. J. of Appl.and Nat. Sc. 11(1): 62-65.
Lindequist, U., Niedermeyer, T.H., Julich, W.D. (2005). The pharmacological potential of mushrooms. Evid Based Complement Alternat Med 2:285-289.
Morales, A.I., Detaille, D., Prieto, M., Puente, A., Briones, E., Arevalo, M., et al. (2010). Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway. Kidney Int; 77(10):861-69.
Nair, Aiswarya, Rao Rashmi, R., Shenoy Preethi, J., Vinod Chandran, S., Teerthanath, Pai Sunil, B., Rakesh, K.B. (2018). Nephroprotective Effect of Aqueous Extract of Pimpinella anisum in Gentamicin Induced Nephrotoxicity in Wistar Rats. Pharmacogn J.; 10(3):403-407.
Organisation for Economic Cooperation and Development (2004). OECD guidelines for the testing of chemicals /section 4: Health effects test no. 423; Acute Oral Toxicity-AcuteTtoxic Class Method.
Ozbek E. (2012). Induction of oxidative stress in kidney. Int J Nephrol., 2012:1-9.
Pragati Srivastava, Rashmi Rao, R., Preethi, J. Shenoy, Poornima Ajay Manjrekar, Teerthanath, S., Bhuvaneshwari, S. (2018). Nephroprotective Effect of Anethum graveolens in a Murine Model of Gentamicin induced Nephrotoxicity. J Young Pharm, 2018; 10(2): 155-158.
Parlakpinar, H., Tasdemir, S., Polat, A., Bay-Karabulut, A., Vardi, N., Ucar, M., Acet, A. (2005). Protective role of caffeic acid phenethyl ester (cape) on gentamicin-induced acute renal toxicity in rats. Toxicology 207, 169–177.
Ramhariya R, Ganeshpurkar A, Ayachi C, Kanojia P, Bansal D, Dubey N. Ameliorative effect of rutin on gentamicin-induced nephrotoxicity in murine model. Austin J Pharmacol Ther 2015;3(1):1066e70.
Rodrigues FA, Prata MM, Oliveira IC, Alves NT, Freitas RE, Monteiro HS, et al. (2014). Gingerol fraction from Zingiber officinale protects against gentamicin-induced nephrotoxicity. Antimicrob Agents Chemother; 58(4):1872-78.
Reiter RJ, Tan D, Sainz RM, Mayo JC, Lopez-Burillo S. (2002). Melatonin: reducing the toxicity and increasing the efficacy of drugs. J Pharm Pharmacology; 54(10):1299-321.
Sener, G., Sehirli, A.O., Altunbas, H.Z., Ersoy, Y., Paskalylu, K., Arbak, S., Ayanoglu-Dulger, G. (2002). Melatonin protects against gentamicin-induced nephrotoxicity in rats. J. Pineal Res. 32 (4), 231–236.
Saud Alarifi, Amin Al-Doaiss, Saad Alkahtani, S.A. Al-Farraj, Mohammed Saad Al-Eissa, B. Al-Dahmash, Hamad Al-Yahya, Mohammed Mubarak (2012). Blood chemical changes and renal histological alterations induced by gentamicin in rats. Saudi Jr of Biol Sc. 19, 103–110
This work is licensed under Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) © Author (s)