The effect of P-alaxin on some neurobehavioural parameters was studied in Swiss white mice. 21 mice were randomly assigned to three groups (n=7) namely; control group, clinical dose group and high dose group. Animals in control group received normal rat chow and standard feed ad libitum. Animals in the clinical dose group were given P-alaxin at a dose of 0.01mg/kg body weight while animals in the high dose group were given P-alaxin at a dose of 0.02mg/kg body weight. The results obtained showed that, in the open field maze test, the clinical dose and high dose groups showed significant increase (P<0.05) in stretch attend posture compared to control. Conversely, there was a significant decrease (P<0.05) in line crossings of high and clinical dose groups when compared to control. In the light/dark transition box test, the clinical and high dose groups showed a significant decrease (P<0.05) in the frequency of line crossings when compared to control. In the morris water maze test, the high and clinical dose groups showed a significant inncrease in frequency of swimming latency when compared to control group. From the total analysis obtained, P-alaxin decreases locomotion and exploratory activities, it impairs motivation and the tendency to investigate the environment as well as reduction in visuospartial learning and memory.
P-Alaxin, Dihydroartemisinin, Piperaquine phosphate, Neurobehaviour
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