S. B. Zade D. M. Agase A.M. Nagwnshi H. N. Nenwani S. N. Qureshi H. Jagyasi


In the present study, investigation were carried out on gills of African cat fish Clarias gariepinus exposed to sub lethal concentrations (80mg/ml,400mg/ml and 800mg/ml) of 2-Methyltetrahydrofuran for 10 days. Lesions were observed in gills tissue of treated fish for long term exposure to Methyltetrahydrofuran (2MTHF). The occurrence and degree of alteration were positively related with the concentration of 2MTHF. Histological examination of the gills of fish treated with 80 mg/ml of 2MTHF for 10 days showed architectural loss, necrosis and desquamation of epithelial layer. Histological examination of the gills of fish treated with 400 mg/ml of 2MTHF for 10 days showed architectural loss, necrosis and mild vaccuolation. The gill filament exhibited telangiectesis, disorganisation of secondary gill lamellae and complete vaccuolation of gills  treated with 800 mg/ml of 2MTHF for 10 days.  The study indicated that 2MTHF had marked effects on the cyto-architecture of the gills of C. gariepinus.  The degree of vaccuolation and necrosis were positively related with the concentration of 2MTHF.


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Gill lamellae, 2-Methyltetrahydrofuran (2MTHF), Nacrosis, Telangiectesis, Vaccuolation

Aycock, G. and David, F. (2007). Solvent Applications of 2-Methyltetrahydrofuran in Organometallic and Biphasic Reactions. J. Org. Proc. Res. Dev., 11:156–159. 
Balabanic, D., Rupnik, M. and Klemenc, A.K. (2011). Negative impact of endocrine-disrupting compounds on human reproductive health. J. Reproduction, Fertility and Development, 23: 403–416.
Chhabra, R.S., Herbert, R. A., Roycroft, J. H., Chou B. , Miller, R. A. and Renne, R. A. (1998). Carcinogenesis Studies of Tetrahydrofuran Vapors in Rats and Mice. J. Tox. Sci., 41:183–188.
De Silva, P. M. C. S., and Samayawardhena, L. A. (2002). Low concentrations of lorsban in water result in far reaching behavioral and histological effects in early life stages in guppy. Ecotox. Environ. Safe., 53: 248- 254.
Dhanapakiam, P., Ramasamy, V.K. and Sampoorani, R. (1998). A study on the histological changes in gills of Channapunctatus in Cauvery river water. J. Envrion. Biol., 19: 265-269.
Dutta, H. M., Munshi, J. S. D., Roy, P. K., Singh, N.K., Motz, L., Adhikari, S. (1997). Effects of diazinon on bluegill sunfish, Lepomis macrochirus, gills: scanning electron microscope observations. Exp. Biol. Online, 2: 1-11.
Dwivedi, H., Sari, R. and Wate, S. (1997). Long term effects of DI-aromatic hydrocarbon in catfish Heteropneustes fossilis. Journal of Ecobiology, 9: 247-254.
El-Sayed, N. K., Salem, S. A., Moursy, A. and Ibrahim, B. M. (1995). Acute and chronic toxicity of some aromatic hydrocarbons on Tilapia zillii. Bulletin of the National Institute of Oceanography and Fisheries, 21: 613-630.
Gupta, A.K., Rajbanshi, V.K. and J. Environ (1995). Histopathological lesions in the selected tissues of Cirrhinus mrigala (Ham.) fingerlings exposed to a sublethal concentration of mercury Biol.,16 (1): 33-36.
Jayachandran, K. and Pugazhendy, K. (2009). Histopathological changes in the gill of Labeo rohita (hamilton) fingerlings exposed to atrazine. J. Sci. Res., 4:219-221.
Leino, R.L., P. Wilkinson and J.G. Anderson. (1987). Histopathological changes in the gills of pearl dace semotilus margarita and fathered minuows pimephales promelas, from experimentally acidified Canadian lakes. Can. J. Fish Aqucat. Sci., 44: 126-134.
Liqun, X., Hongling. L., Xiaowei, Z., Markus, H., John, P. and Hongxia, Yu.(2014). A comparison of statistical methods for deriving freshwater quality criteria for the protection of aquatic organisms. Environ Sci Pollut. Res., 21:159–167.
 Man, He., Zhou, Da-Qing, Ge, Hong-Li, Huang, Mei-Yu, and Jiang Ying-Yan (2003).Catalytic Behavior of Wool-Rh Complex in AymmetricHydrogenation of 2-Methyl Furan. Polymers for Advanced Technologies 14: 273–277.
NTP (1998). Toxicology and Carcinogenesis Studies of Tetrahydrofuran (CAS No. 109-99-9) in F344/N Rats and B6C3F1 Mice. Natl Toxicol Program Tech Rep Ser.,475:1-244.
Rhind, S.M.(2009). Anthropogenic pollutants: a threat to ecosystem sustainability. J. Phil. Trans. R. Soc. B., 364:3391–3401.
Roy, P.K. and J.S. Datta Munshi, 1991. Malathion induced structural and morphometric changes of gills of a freshwater major carp Cirrhinus mrigala (Ham.). J. Environ. Biol., 12(1): 79-87.
Sakthivel, M. (1994). Sublethal effects of tannery and textile mill effluents on gill structure, respiration and bioconcentration of Chromium in Cyprinus carpio (Linnaeus). J. Environ. Poll. 1(3-4): 83-88.
Sharma, A and M.S. Sharma (1991): Histopathology of zinc to developing. Lebistes reticulatus (Peters) and Cyprinus carpio (Linnaeus). Poll-Res. 10(3): 183-188.
Singh, A.N. and Datta Munshi. (1996). Scanning electron microscopic evaluation of the effects of short and long term exposure of copper and mercury on the gills of Channa punctatus (Bloch) J.S.: J. Freshwater Biol., 8 (1): 51-55.
Tilak, K.S., K. Veeraiah and K. Yacobu, 2001. Studies of histopathological chanes in the gill, liver and kidney of Ctenopharyngodon idellus (Valenciennes) exposed to technical fenvalerate and EC20%. Poll. Res., 20(3): 387-393.
Vijayalakshmi, S and Tilak K.S. (1996). Effect of pesticides on the gill morphology of Labeo rohita. J. Ecotoxicol. Environ. Monit. 6: 59-64.
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Zade, S. B., Agase, D. M., Nagwnshi, A., Nenwani, H. N., Qureshi, S. N., & Jagyasi, H. (2018). Studies on the toxicity of 2-Methyltetrahydrofuran on the histopathology of gills of African catfish Clarias gariepinus. Journal of Applied and Natural Science, 10(2), 765-769. https://doi.org/10.31018/jans.v10i2.1775
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