Influence of silica intoxication on female reproductive organs with therapeutic agents vitamin E and vitamin C
Article Main
Abstract
The aim of the present study was to observe the alteration of blood biochemical and histopathological variables after silica exposure, and also to show whether therapeutic agents (Vitamin E + Vitamin C) used in study may provide recovery against exposure to silica. In this study, silica was administered as silicon dioxide at a dose of 40 mg/kg for 28 days to produce toxic effect. Recovery pattern was evaluated by Vitamin E + vitamin C (50 mg/kg, ip + 100 mg/kg, po), The present study showed alterations in the activities of oestrogen and LH were significantly decreased in experimental rats after 28 days of silica intoxication. The level of progesteron and FSH, were also decreased. Therapeutic agents i.e. vitamin E and vitamin C recouped the values to normal and near to control.
Article Details
Article Details
Keywords
Histopathological variables, Recovery pattern, Blood biochemical, Silica
References
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Weiss, W., (2000). Asbestosis and lober site of lung cancer. Occup. Environ. Med., 57: 358.
Wilson, R., Langer, A. M., Nolan, R. P., Barnard, J., Gee, L. and Ross, M., (1994). Asbestos in New York city public school buildings- public policy: is there a scientific basis. Reg. Toxicol. and Pharmacol., 20: 161.
Yucesoy, B., Vallyathan, V., Landsittel, D. P., Sharp, D. S., Wewton, A., Burleson, G. R., Simionova, P., McKinstry, M. Luster, M. I. ((2001). Association of tumor necrosis factor- á and interleukin-1 gene polymorphism with silicosis. J. Toxicol. and appl. Pharmacol., 172: 75.
Biswas, N. M. and Ghosh P. K. (2004). Effect of lead on male gonadal activity in albino Rats. Kathmandu University Medical Journal, 2 (1): 43-46.
CFR (1992). Exemptions from the requirement of a tolerance. Code of Federal Regulations, Vol. 40:413.
Chakarborti, S., Chaudhary, A. and Chaudhary, R.R. (1968). Antifertility effect of green leaves of Artobotrys odoratissimus Linn. J. Indian Med. Ass., 51 (5): 227 - 229.
Everett, J. (1962). The influence of oestradiol and progesterone on the endometrium of the guinea pig in vitro. J. Endocrinol., 24: 491-496.
Hnizdo, E. and Sluis-Cremer, G. K., (1991). Silica exposure, silicosis and lung cancer: A mortality study of south African gold miners. Br. J. Ind. Med., 48: 53.
Hnizdo, E., (1990). Combined effect of silica dust and tobacco smoking on mortality from chronic obstructive lung disease in gold minters. Br. J. Ind. Med., 47: 656.
Jaffrey, L. L., O’Sullivan, M. F., Corn, C. J., Williams, M. G. and Dodson, R. F., (1999). Asbestosis and small lung cancer in a clutch refabricator. Occup. Environ. Med., 56: 602.
Karkun J. N. and Mehrotra P. K. (1973). Studies on physiology and biochemistry of female genital tract; Response of uterus, cervix and vagina of albino rat to cis-transclomiphere in the presence or absence of oestrogen. Indian J. Exp. Biol., 11 (7): 14.
Kholkute, S.D. and Udupa, K.N. (1974). Antifertility properly of Hibiscus rosa sinensis Linn. J. Res. Indian Med., 9 (4) : 99 - 102.
Kholkute, S.D., Chatterjee, S. and Udupa, K.N. (1976). Effect of Hibiscus rosasinensis flower on oestrus cycle and reproductive organs in rats. Indian J. Exp. Biol., 14 : 703.
Lerner, L. J. (1969). The biology of non steroidal antifertility agents in contraception, chemical control fertility. Daniel Lednicer Marcel Dekker Inc.P. 161.
Magnani, C., Mollo, F., Paoletti, L., Bellis, D., Bernardi, P., Betta, P., Botta, M., Falchi, M., Ivaldi, C. and Pavesi, M., (1998). Asbestos lung burden and asbestosis after occupational and environmental exposure in an asbestos cement manufacturing area: a necropsy study. Occup. Environ. Med., 55: 840.
Malmberg, P., Hedenstrom, H. and Sundblad, B. M., (1993): Changes in lung function of granite crushers exposed to moderately high silica concentrations: A 12-year follow-Up. Br. J. Ind. Med., 50: 726.
Packer, L. and Landvik, S., (1989). Vitamin E: Introduction to biochemistry and health benefits. In: Diplock, A. T., Machlin, J. L., Proyr, W. A., (Eds), Vitamin E, Biochemistry and health implications. New York Acad. of Science, New York. 1: 6.
Sharma, J.D., Sharma, L. and Yadav, P. (2007). Antifertility efficacy of Piper betle Linn. (Petiole) on female Albino Rats. Asian J. Exp. Sci.,21 (1): 145-150
Suresh, C. and Tiwary, R. S., (1999). Free radicals in health and disease. Everyman’s Sciences, 33:149.
Vallyathan, V., Shi, X., Dalal, N. S. and Castranova, V., (1988): Generation of free radicals from freshly fractured silica dust: potential role in acute silica induced lung injury. Am. Rev. Respir. Dis., 138:1213.
Vanessa, V, Barrett, C., Roycroft, J., Schuman, L., Dankovic, D., Baron, P., Martomen, T., Papelko, W. and Lai, D., (1996). Workshop Report. Chronic inhalation toxicity and carcinogenicity testing of respirable fibrous particles. Regul. Toxicol. and Pharmacol., 24: 202.
Weiss, W., (2000). Asbestosis and lober site of lung cancer. Occup. Environ. Med., 57: 358.
Wilson, R., Langer, A. M., Nolan, R. P., Barnard, J., Gee, L. and Ross, M., (1994). Asbestos in New York city public school buildings- public policy: is there a scientific basis. Reg. Toxicol. and Pharmacol., 20: 161.
Yucesoy, B., Vallyathan, V., Landsittel, D. P., Sharp, D. S., Wewton, A., Burleson, G. R., Simionova, P., McKinstry, M. Luster, M. I. ((2001). Association of tumor necrosis factor- á and interleukin-1 gene polymorphism with silicosis. J. Toxicol. and appl. Pharmacol., 172: 75.
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Influence of silica intoxication on female reproductive organs with therapeutic agents vitamin E and vitamin C. (2011). Journal of Applied and Natural Science, 3(1), 82-85. https://doi.org/10.31018/jans.v3i1.159
