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Terence P. Barry Padma Marwah Ashok Marwah

Abstract

Two sediment samples that differed with respect to total organic carbon and texture (“sand†and “clayâ€) were exposed to radio inert 17a-methyltestosterone (MT) or [14C]-radiolabeled 17a-methyltestosterone (14C-MT), under both aerobic and anaerobic conditions, for up to 56 days, to characterize the fate of MT in the aquatic environment. Radio inert MT was quantified by a highly sensitive liquid chromatography/mass spectrometry (LCMS) method and radioactive MT was quantified by HPLC using an in-line flow liquid scintillation counter (LSC). The
data suggest that MT entering the aquatic environment is converted into metabolites that become tightly associated with the sediment. Half-lives for MT dissipation in the sediment systems ranged from 2-9 days, depending on the sediment type and the presence of oxygen. Sediment type had little effect on MT dissipation. The mineralization of MT under aerobic conditions was low (<9% conversion of MT to CO2).

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Keywords

17a-Methyltestosterone (MT), Aquatic-Sediment, Radio-HPLC, LC-MS, Aerobic, Anaerobic

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How to Cite
Barry, T. P., Marwah, P., & Marwah, A. (2011). Transformation of 17a-methyltestosterone in aquatic-sediment systems. Journal of Applied and Natural Science, 3(1), 1-9. https://doi.org/10.31018/jans.v3i1.145
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Research Articles