Plant sterols for human health- A review
Article Main
Abstract
The aim of the article was to review phytosterols as functional food and its significance in lowering cholesterol as well as its specific effect on human health. Phytosterols has been known for its cholesterol lowering action long time back but the uprising of phytosterols in form of functional foods gained the interest once again. Fatty food matrix provides optimal solubility but fortification of phytosterols with other food matrices like low fat fermented milk, bread, juice are showing positive results. A dose of 2 g/day of either steryl or stanyl esters has been prescribed for an optimum effect which has been confirmed by FDA and EC. A number of studies have documented the safety and the efficiency of phytosterols. But there is still a big question mark on the use of it because of their adverse effect on body in form of Phytosterol oxidation products (POPs). It needs further investigation to elucidate effect of POPs within body.
Article Details
Article Details
Keywords
Cholesterol lowering agent, Phytostanols, Phytosterols, Sitosterolemia
References
Acuff, R.,V., Cai, D.J., Dong, Z.P. and Bell, D. (2007). The lipid lowering effect of plant sterol ester capsules in hypercholesterolemic subjects. Lipids Health Dis., 6:11.
Berge, K.E., Tian, H., Graf, G.A., Yu, L., Grishin, N.V. and Schultz, J. (2000). Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Sci., 290 : 1771-1775.
Berger, A., Jones, P.J. and Abumweis, S.S. (2004). Plant sterols: factors affecting their efficacy and safety as functional food ingredients. Lipids Health Dis., 3:5.
Bergmann, K.V., Sudhop, T. and Lutjohann, D. (2005). Cholesterol and plant sterol absorption: recent insights. Am. J. Cardiol., 96 (1) : 10–4.
Bouic, P.J.D., Clark, A. and Lamprecht, J. (1999). The effects of ß-sitosterol (BSS) and ß-sitosterol glucoside (BSSG) mixture on selected immune parameters of marathon runners: inhibition of post marathon immune suppression and inflammation. Int. J. Sports Med., 20 : 258-262.
Bruckerdorfer, K.R., Demel, R.A., de Gier, J. and van Deenen, L.L.M. (1969). The effect of partial replacement of membrane cholesterol by other steroids on the osmotic fragility and glycerol permeability of erythrocytes. Biochim. Biophys. Acta., 183 : 334-345.
Brufaua, G., Canelab, M.A. and Rafecasa, M. (2008). Phytosterols: physiologic and metabolic aspects related to cholesterol- lowering properties. Nutr. Res., 28 : 217–225.
Cantrill, R. and Kawamura, Y. (2008). Phytosterols, phytostanols and their esters chemical and technical assessment, pp.1-13. www.fao.org.
Chen, B., McClements, D.J. and Decker, E.A. (2013). Design of foods with bioactive Lipids for improved health. Annu. Rev. Food Sci. Technol., 4 : 35-56.
Chen, C.Y. and Blumberg, J.B. (2008). Phytochemical composition of nuts. Asia. Pac. J. Clin. Nutr., 17 : 329-332.
Child, P. and Kuksis, A. (1982). Differential uptake of cholesterol and plant sterols by rat erythrocytes in vitro. Lipids, 17 : 748-754.
Clifton, P.M., Clifton, P.M., Mano, M., Duchateau, G.S., van der Knaap, H.C. and Trautwein, E.A. (2008). Dose– response effects of different plant sterol sources in fat spreads on serum lipids and C-reactive protein and on the kinetic behavior of serum plant sterols. Eur. J. Clin. Nutr., 62(8):968-977.
Davis, H.R., Zhu, L.J., Hoos, L.M., Tetzloff, G., Maguire, M. and Liu, J. (2004). Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole body cholesterol homeostasis. J. Biol. Chem., 279 : 33586-33592.
Demonty, I., Chan, Y.M., Pelled, D. and Jones, P.J.H. (2006). Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols. Am. J. Clin. Nutr., 84 (6) : 1534–1542.
Earnest, C.P., Mikus, C.R., Lemieux, I., Arsenault, B.J. and Church, T.S. (2007). Examination of encapsulated phytosterol ester supplementation on lipid indices associated with cardiovascular disease. Nutr., 23 (9) : 625–633.
Eisenberg, D. (2003). Naturally available oils contain phytosterols that affect cholesterol absorption. Curr. Atheroscler. Rep. 5(1) : 78.
Fernandes, P. and Cabral, J.M.S. (2007). Phytosterols: applications and recovery methods. Bioresour. Technol., 98 : 2335-2350.
Garcia-Llatasa, G. and Rodriguez-Estradab, M.R. (2011). Current and new insights on phytosterol oxides in plant sterol-enriched food. Chem. Phy. Lipid. 164 : 607-624.
Gupta, A.K., Savopoulos, C.G., Ahuja, J. and Hatzitolios, A.I. (2011). Role of phytosterols in lipid-lowering: current perspectives. Q. J. Med., 104 : 301-308.
Hansel, B., Nicolle, C., Lalanne, F., Tondu, F., Lassel, T., Donazzolo, Y. (2007). Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia. Am. J. Clin. Nutr., 86 : 790-796.
Heinemann, T., Axtmann, G. and von Bergmann, K. (1993). Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur. J. Clin. Invest., 23 : 827-831.
Hendriks, H.F.J., Brink, E.J., Meijer, G.W., Princen, H.M.G., Ntanios, F.Y. (2003). Safety of long-term consumption of plant sterol esters-enriched spread. Eur. J. Clin. Nutr., 57 : 681-692.
Hwang, K.K. and Kelsey, M.I. (1978). Evidence of epoxide hydrase activity in human intestinal microflora. Cancer Biochem. Biophys., 3 (1) :31-35.
Ikeda, I., Tanaka, K., Sugano, M., Vahouny, G.V. and Gallo, L.L. (1988). Discrimination between cholesterol and sitosterol for absorption in rats. J. Lipid Res., 29 : 1583-1591.
Jakulj, L., Trip, M.D., Sudhop, T., Bergmann, K.V., Kastelein, J.J.P. and Vissers, M.N. (2005). Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe: effects on plasma lipid levels. J. Lipid Res., 46 : 2692-2698.
Jimenez-Escrig, A., Santos-Hidalgo, A.B. and Saura-Calixto, F. (2006). Common sources and estimated intake of plant sterols in the Spanish diet. J. Agric. Food Chem., 54 : 3462–3471.
John, A.P., Janice, F., Wang, P., Marlia, M.B., Lee, L., Catherine, K., Carl, L.K. (2006). Cocoa flavanol-enriched snack bars containing phytosterols effectively lower total and low-density lipoprotein cholesterol levels. J. Am. Diet. Assoc., 106 : 1804-1813.
Jones, P.J. and Abumweis, S.S.(2009). Phytosterols as functional food ingredients: linkages to cardiovascular disease and cancer. Curr. Opin. Clin. Nutr. Metab. Care., 12(2) : 147–151.
Jones, P.J., Raeini-Sarjaz, M., Ntanios, F.Y., Vanstone, C.A., Feng, J.Y. and Parsons, W.E. (2000) Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. J. Lipid Res., 41 : 697–705.
Jong, A.D., Plat, J. and Mensink, R.P. (2003). Metabolic effects of plant sterols and stanols (Review). J. Nutr. Biochem. 14 : 362-369.
Jong, N de., Zuur, A., Wolfs, M.C.J., Wendel-Vos, G.C.W., Raaij J.M.A. van and Schuit, A.J. (2007). Exposure and effectiveness of phytosterol/-stanolenriched margarines. Eur. J. Clin. Nutr., 61 : 1407–1415.
Katan, M.B., Grundy, S.M., Jones, P., Law, M., Miettinen, T. and Paoletti, R. (2003). Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin. Proc., 78 : 965-978.
Kennedy, A.R. (1995). The evidence for soybean products as cancer preventive agents. J. Nutr. 125 : 733-743.
Klippel, K.F., Hilt, D.M. and Schip, B.A. (1997). Multicentric, placebo-controlled, double-blind clinical trial of ßsitosterol in patients with benign prostatic hyperplasia. Br. J. Urol., 80 : 427-432.
Kritchevskya, D.T. and Chen, S.C. (2005). Phytosterolshealth benefits and potential concerns: a review. Nutr. Res., 25 : 413–428.
Lavová, B., Hároniková, A., Márová, I. and Urminská, D. (2013) Production of ergosterol by Saccharomyces cerevisiae. JMBFS, 2 (1): 1934-1940.
Law, M. (2000). Plant sterol and stanol margarines and health. Br. Med. J., 320: 861-864.
Ling, W.H. and Jones, P.J.H. (1995). Dietary phytosterols: a review of metabolism, benefits and side effects. Life Sci., 57 (3) : 195-206.
Madsen, M.B., Jensen, A.M. and Schmidt, E.B. (2007). The effect of a combination of plant sterol-enriched foods in mildly hypercholesterolemic subjects. Clin. Nutr., 26(6) : 792–798.
Malinowski, J.M. and Gehret, M.M. (2010). Phytosterols for dyslipidemia. Am. J. Health Syst. Pharm. 67 : 1165- 1173.
Marangoni, F. and Poli, A. (2010). Phytosterols and cardiovascular health. Pharmacol. Res. 61(3) : 193-199.
Matvienko, O.A., Lewis, D.S., Swanson, M., Arndt, B., Rainwater, D.L., Stewart, J. and Alekel, D.L., (2002). A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men. Am. J. Clin. Nutr. 76 : 57-64.
Micallef, M.A. and Garg, M.L. (2008). Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals. Atherosclerosis 204 (2) : 476-482.
Micallef, M.A., Garg, M.L. (2009). Beyond blood lipids: phytosterols, statins and omega-3 polyunsaturated fatty acid therapy for hyperlipidemia. J. Nutr. Biochem. 20 : 927-939.
Miettinen, T.A., Vuoristo, M., Nissinen, M., Jarvinen, H.J. and Gylling, H. (2000). Serum biliary and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. Am. J. Clin. Nutr. 71 : 1095-1102.
Miettinen. T.A., Tilvis, R.S., Kesaniemi, Y.A. (1990). Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of randomly selected male population. Am. J. Epidemiol. 131(1) : 20-31.
Mora, M.P., Tourne-peteilh, C., Charveron, C., Fabre, B., Milon, A. and Muller, I. (1999). Optimization of plant sterols incorporation in human keratinocyte plasma membrane and modulation of membrane fluidity. Chem. Phys. Lipids. 101 : 255–265.
Moreau, R.A., Whitaker, B.D. and Hicks, K.B. (2002). Phytosterols, phytostanols and their conjugates in foods: structural diversity, quantitative analysis and healthpromoting uses. Proq. Lipid Res. 41(6) : 457-500.
Naumann, E., Plat, J., Kester, A.D. and Mensink, R.P. (2008). The baseline serum lipoprotein profile is related to plant stanol induced changes in serum lipoprotein cholesterol and triacylglycerol concentrations. J. Am. Coll. Nutr. 27 : 117-126.
Nguyen, T.T. (1999). The cholesterol-lowering action of plant stanol esters. J. Nutr. 129 : 2109-2112.
Nguyen, T.T. and Dale, L.C. (1999). Plant stanol esters and vitamin K. Mayo Clin. Proc. 74 : 642-643.
Noakes, M., Clifton, P., Ntanios, F., Shrapnel, W., Record, I. and McInerney, J. (2002). An increase in dietary carotenoids when consuming plant sterols or stanols is effective in maintaining plasma carotenoid concentrations. Am. J. Clin. Nutr. 75 : 79–86.
Normen, L., Dutta, P., Lia, A. and Andersson, H. (2000). Soy sterol esters and ß-sitostanol ester as inhibitors of cholesterol absorption in human small bowel. Am. J. Clin. Nutr. 71 : 908-913.
Oksana, A.M., Douglas, S.L., Mike, S., Beth, A., David, L.R., Stewart, J., and Alekel. D Lee (2002). A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men. Am. J. Clin. Nutr. 76 : 57–64.
Ortega, R.M., Palencia, A., Lo´pez-Sobaler, A.M. (2006). Improvement of cholesterol levels and reduction of cardiovascular risk via the consumption of phytosterols. Br. J. Nutr. 96(1) : 89-93.
Ostlund Jr., R.E. (2002). Phytosterols in human nutrition. Annu. Rev. Nutr. 22 : 533-549.
Otaegui-Arrazola, Menendez-Carreno, M., Ansorena, D. and Astiasaran, D. (2010). Oxysterols: a world to explore. Food Chem. Toxicol. 48 : 3289-3303.
Phillips, K.M., Ruggio, D.M. and Ashraf-Khorassani, M. (2005). Phytosterol composition of nuts and seeds commonly consumed in the United States. J. Agric. Food. Chem. 53(24) : 9436–9445.
Piironen, V. and Toivo, J. (2003). Plant sterols in vegetables, fruits and berries. J. Sci. Food Agric. 83 : 330-337.
Piironen, V., Lindsay, D.G., Miettinen, T.A., Toivo, J. and Lampi, A.M. (2000). Plant sterols: Biosynthesis, biological function and their importance to human nutrition. J. Sci. Food Agric. 80 : 939-966.
Plat, J. and Mensink, R.P. (2001). Effects of diets enriched with two different plant sterol ester mixtures on plasma ubiquinol-10 and fat-soluble antioxidant concentrations. Metabol. 50 : 520-529.
Plat, J. and Mensink, R.P. (2005). Plant stanol and sterol esters in the control of blood cholesterol levels: mechanism and safety aspects. Am. J. Cardiol. 96(1) : 15-22.
Pollak, O.J. (1953). Reduction of Blood Cholesterol in Man. Circulation. 7 : 702-706.
Qianchun, D., Yu, X., Xu, J., Liu, C., Fenghong, H., Qingde, H., and Jine, Y. (2012). Effect of flaxseed oil fortified with vitamin E and phytosterols on antioxidant defense capacities and lipids profile in rats. J. Food Sci. 77 : 135-140.
Qu?´lez, J., Rafecas, M., Brufau, G., Garc?´a-Lorda, P., Meg?´as, I. and Bullo´ M. (2003). Bakery products enriched with phytosterol esters, £tocopherol and ?carotene decrease plasma ldl-cholesterol and maintain plasma ?carotene concentrations in normocholesterolemic men and women. J. Nutr. 133 : 3103-3109.
Racette, SB, Lin, X., Lefevre, M., Spearie, C.A., Most, M.M., Ma, L. and Ostlund R.E. (2010). Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. Am. J. Clin. Nutr. 91(1) : 32-38.
Rodwell, V.W., Nordstrom, J.L., Mitschelen, J.J. (1976). Regulation of HMGCoA reductase. Adv. Lipid Res. 14 : 1-74.
Rozner, S. and Garti, N. (2006). The activity and absorption relationship of cholesterol and phytosterols. Colloids Surf. A Physicochem. Eng. Asp. 282 : 435-456.
Russell, J.C., Ewart, H.S., Kelly, S.E., Kralovec, J., Wright, J.L.C. and Dolphin P.J. (2002). Improvement of vascular dysfunction and blood lipids of insulin-resistant rats by a marine oil-based phytosterol compound. Lipids 37 (2) : 147–152.
Ryan, E., Mccarthy, F.O., Maguire, A.R., O’brien, N.M. (2009). Phytosterol oxidation products: their formation, occurrence, and biological effects of phytosterol oxidation products Food Rev. Int. 25:157-174.
Sailaja, P.S.S., Raju, M.P., Supraja, Hymavathi, T.V.N., Poshadri, A., Kuna, A. (2014). Effect of phytosterols supplemented health food (papaya fruit bar) on serum cholesterol and LDL cholesterol levels in normocholesterolemic and mildly hypercholesterolemic subjects - a pilot study. IOSR-JESTFT . 8(1): 1-8.
Salen, G., Shefer, S., Nguyen, L., Ness, G.C., Tint, G.S. and Shore, V. (1992), Sitosterolemia. J. Lipid Res. 33 : 945-955.
Salen, G., Shore, V., Tint, G.S., Forte, T., Shefer, S., Horak, I. et al. (1989). Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis. J. Lipid Res., 30 : 1319-1330.
Sanders. D.J., Minter, H.J., Howes, D. and Hepburn, P.A. (2000). The safety evaluation of phytosterol esters. The comparative absorption and tissue distribution of phytosterols in the rat. Food Chem. Toxicol., 38 : 485-491.
Shin MJ, Lee, J.H., Jang, Y., Lee-Kim, Y.C., Park, E., Kim, K.M., Chung, B.C. and Chung, N. (2005). Micellar phytosterols effectively reduce cholesterol absorption at low doses. Ann. Nutr. Metab., 49(5) : 346–351.
Sridevi, D., Ishwarlal, J. and Vega-López, S. (2004). Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. Arterioscler. Thromb. Vasc. Biol., 24 : 25-28.
Talati, R., Sobieraj, D.M., Makanji, S.S., Phung, O.J. and Coleman, C.I. (2010). The comparative efficacy of plant sterols and stanols on serum lipids: a systematic review and meta-analysis. J. Am. Diet. Assoc., 110 : 719-726.
Tikkanen, M.J. (2005). Plant sterols and stanols. Handb. Exp. Pharmacol., 170 : 215–230.
USDA (2011) US Department of Agriculture, agriculture research service, USDA nutrient database for standard reference, release27, accessed on 22 April 2015 from http://www.nal.usda.gov/fnic/foodcomp/search/
Vanmierlo, T., Husche, C., Schött, H.F., Pettersson, H., Lütjohann, D. (2013). Plant sterol oxidation products - analogs to cholesterol oxidation products from plant origin? Biochimie., 95 : 464-472.
Weihrauch, J.L. and Gardner, J.M. (1978). Sterol content of foods of plant origin. J. Am. Diet Assoc., 73 (1) : 39–47.
Wolfs, M., de Jong, N., Ocké, M.C., Verhagen, H. and Verschuren, W.M. (2006). Effectiveness of customary use of phytosterol/-stanol enriched margarines on blood cholesterol lowering. Food Chem.Toxicol., 44 (10) : 1682–1688.
Woyengo, T.A., Ramprasath, V.R. and Jones, P.J.H. (2009). Anticancer effects of phytosterols. Eur. J. Clin. Nutr., 63 : 813–820.
Wu, T., Fu, J., Yang, Y., Zhang, L. and Han, J. (2009). The effects of phytosterols/stanols on blood lipid profiles: a systematic review with meta-analysis. Asia Pac. J. Clin. Nutr., 18 (2) : 179-186.
Yvonne O’Callaghan, McCarthy, F.O., Nora M. O’Brien (2014). Recent advances in phytosterol oxidation products Biochemical and biophysical research communications. http://dx.doi.org/10.1016/j.bbrc.2014.01.148
Berge, K.E., Tian, H., Graf, G.A., Yu, L., Grishin, N.V. and Schultz, J. (2000). Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Sci., 290 : 1771-1775.
Berger, A., Jones, P.J. and Abumweis, S.S. (2004). Plant sterols: factors affecting their efficacy and safety as functional food ingredients. Lipids Health Dis., 3:5.
Bergmann, K.V., Sudhop, T. and Lutjohann, D. (2005). Cholesterol and plant sterol absorption: recent insights. Am. J. Cardiol., 96 (1) : 10–4.
Bouic, P.J.D., Clark, A. and Lamprecht, J. (1999). The effects of ß-sitosterol (BSS) and ß-sitosterol glucoside (BSSG) mixture on selected immune parameters of marathon runners: inhibition of post marathon immune suppression and inflammation. Int. J. Sports Med., 20 : 258-262.
Bruckerdorfer, K.R., Demel, R.A., de Gier, J. and van Deenen, L.L.M. (1969). The effect of partial replacement of membrane cholesterol by other steroids on the osmotic fragility and glycerol permeability of erythrocytes. Biochim. Biophys. Acta., 183 : 334-345.
Brufaua, G., Canelab, M.A. and Rafecasa, M. (2008). Phytosterols: physiologic and metabolic aspects related to cholesterol- lowering properties. Nutr. Res., 28 : 217–225.
Cantrill, R. and Kawamura, Y. (2008). Phytosterols, phytostanols and their esters chemical and technical assessment, pp.1-13. www.fao.org.
Chen, B., McClements, D.J. and Decker, E.A. (2013). Design of foods with bioactive Lipids for improved health. Annu. Rev. Food Sci. Technol., 4 : 35-56.
Chen, C.Y. and Blumberg, J.B. (2008). Phytochemical composition of nuts. Asia. Pac. J. Clin. Nutr., 17 : 329-332.
Child, P. and Kuksis, A. (1982). Differential uptake of cholesterol and plant sterols by rat erythrocytes in vitro. Lipids, 17 : 748-754.
Clifton, P.M., Clifton, P.M., Mano, M., Duchateau, G.S., van der Knaap, H.C. and Trautwein, E.A. (2008). Dose– response effects of different plant sterol sources in fat spreads on serum lipids and C-reactive protein and on the kinetic behavior of serum plant sterols. Eur. J. Clin. Nutr., 62(8):968-977.
Davis, H.R., Zhu, L.J., Hoos, L.M., Tetzloff, G., Maguire, M. and Liu, J. (2004). Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole body cholesterol homeostasis. J. Biol. Chem., 279 : 33586-33592.
Demonty, I., Chan, Y.M., Pelled, D. and Jones, P.J.H. (2006). Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols. Am. J. Clin. Nutr., 84 (6) : 1534–1542.
Earnest, C.P., Mikus, C.R., Lemieux, I., Arsenault, B.J. and Church, T.S. (2007). Examination of encapsulated phytosterol ester supplementation on lipid indices associated with cardiovascular disease. Nutr., 23 (9) : 625–633.
Eisenberg, D. (2003). Naturally available oils contain phytosterols that affect cholesterol absorption. Curr. Atheroscler. Rep. 5(1) : 78.
Fernandes, P. and Cabral, J.M.S. (2007). Phytosterols: applications and recovery methods. Bioresour. Technol., 98 : 2335-2350.
Garcia-Llatasa, G. and Rodriguez-Estradab, M.R. (2011). Current and new insights on phytosterol oxides in plant sterol-enriched food. Chem. Phy. Lipid. 164 : 607-624.
Gupta, A.K., Savopoulos, C.G., Ahuja, J. and Hatzitolios, A.I. (2011). Role of phytosterols in lipid-lowering: current perspectives. Q. J. Med., 104 : 301-308.
Hansel, B., Nicolle, C., Lalanne, F., Tondu, F., Lassel, T., Donazzolo, Y. (2007). Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia. Am. J. Clin. Nutr., 86 : 790-796.
Heinemann, T., Axtmann, G. and von Bergmann, K. (1993). Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur. J. Clin. Invest., 23 : 827-831.
Hendriks, H.F.J., Brink, E.J., Meijer, G.W., Princen, H.M.G., Ntanios, F.Y. (2003). Safety of long-term consumption of plant sterol esters-enriched spread. Eur. J. Clin. Nutr., 57 : 681-692.
Hwang, K.K. and Kelsey, M.I. (1978). Evidence of epoxide hydrase activity in human intestinal microflora. Cancer Biochem. Biophys., 3 (1) :31-35.
Ikeda, I., Tanaka, K., Sugano, M., Vahouny, G.V. and Gallo, L.L. (1988). Discrimination between cholesterol and sitosterol for absorption in rats. J. Lipid Res., 29 : 1583-1591.
Jakulj, L., Trip, M.D., Sudhop, T., Bergmann, K.V., Kastelein, J.J.P. and Vissers, M.N. (2005). Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe: effects on plasma lipid levels. J. Lipid Res., 46 : 2692-2698.
Jimenez-Escrig, A., Santos-Hidalgo, A.B. and Saura-Calixto, F. (2006). Common sources and estimated intake of plant sterols in the Spanish diet. J. Agric. Food Chem., 54 : 3462–3471.
John, A.P., Janice, F., Wang, P., Marlia, M.B., Lee, L., Catherine, K., Carl, L.K. (2006). Cocoa flavanol-enriched snack bars containing phytosterols effectively lower total and low-density lipoprotein cholesterol levels. J. Am. Diet. Assoc., 106 : 1804-1813.
Jones, P.J. and Abumweis, S.S.(2009). Phytosterols as functional food ingredients: linkages to cardiovascular disease and cancer. Curr. Opin. Clin. Nutr. Metab. Care., 12(2) : 147–151.
Jones, P.J., Raeini-Sarjaz, M., Ntanios, F.Y., Vanstone, C.A., Feng, J.Y. and Parsons, W.E. (2000) Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. J. Lipid Res., 41 : 697–705.
Jong, A.D., Plat, J. and Mensink, R.P. (2003). Metabolic effects of plant sterols and stanols (Review). J. Nutr. Biochem. 14 : 362-369.
Jong, N de., Zuur, A., Wolfs, M.C.J., Wendel-Vos, G.C.W., Raaij J.M.A. van and Schuit, A.J. (2007). Exposure and effectiveness of phytosterol/-stanolenriched margarines. Eur. J. Clin. Nutr., 61 : 1407–1415.
Katan, M.B., Grundy, S.M., Jones, P., Law, M., Miettinen, T. and Paoletti, R. (2003). Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin. Proc., 78 : 965-978.
Kennedy, A.R. (1995). The evidence for soybean products as cancer preventive agents. J. Nutr. 125 : 733-743.
Klippel, K.F., Hilt, D.M. and Schip, B.A. (1997). Multicentric, placebo-controlled, double-blind clinical trial of ßsitosterol in patients with benign prostatic hyperplasia. Br. J. Urol., 80 : 427-432.
Kritchevskya, D.T. and Chen, S.C. (2005). Phytosterolshealth benefits and potential concerns: a review. Nutr. Res., 25 : 413–428.
Lavová, B., Hároniková, A., Márová, I. and Urminská, D. (2013) Production of ergosterol by Saccharomyces cerevisiae. JMBFS, 2 (1): 1934-1940.
Law, M. (2000). Plant sterol and stanol margarines and health. Br. Med. J., 320: 861-864.
Ling, W.H. and Jones, P.J.H. (1995). Dietary phytosterols: a review of metabolism, benefits and side effects. Life Sci., 57 (3) : 195-206.
Madsen, M.B., Jensen, A.M. and Schmidt, E.B. (2007). The effect of a combination of plant sterol-enriched foods in mildly hypercholesterolemic subjects. Clin. Nutr., 26(6) : 792–798.
Malinowski, J.M. and Gehret, M.M. (2010). Phytosterols for dyslipidemia. Am. J. Health Syst. Pharm. 67 : 1165- 1173.
Marangoni, F. and Poli, A. (2010). Phytosterols and cardiovascular health. Pharmacol. Res. 61(3) : 193-199.
Matvienko, O.A., Lewis, D.S., Swanson, M., Arndt, B., Rainwater, D.L., Stewart, J. and Alekel, D.L., (2002). A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men. Am. J. Clin. Nutr. 76 : 57-64.
Micallef, M.A. and Garg, M.L. (2008). Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals. Atherosclerosis 204 (2) : 476-482.
Micallef, M.A., Garg, M.L. (2009). Beyond blood lipids: phytosterols, statins and omega-3 polyunsaturated fatty acid therapy for hyperlipidemia. J. Nutr. Biochem. 20 : 927-939.
Miettinen, T.A., Vuoristo, M., Nissinen, M., Jarvinen, H.J. and Gylling, H. (2000). Serum biliary and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. Am. J. Clin. Nutr. 71 : 1095-1102.
Miettinen. T.A., Tilvis, R.S., Kesaniemi, Y.A. (1990). Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of randomly selected male population. Am. J. Epidemiol. 131(1) : 20-31.
Mora, M.P., Tourne-peteilh, C., Charveron, C., Fabre, B., Milon, A. and Muller, I. (1999). Optimization of plant sterols incorporation in human keratinocyte plasma membrane and modulation of membrane fluidity. Chem. Phys. Lipids. 101 : 255–265.
Moreau, R.A., Whitaker, B.D. and Hicks, K.B. (2002). Phytosterols, phytostanols and their conjugates in foods: structural diversity, quantitative analysis and healthpromoting uses. Proq. Lipid Res. 41(6) : 457-500.
Naumann, E., Plat, J., Kester, A.D. and Mensink, R.P. (2008). The baseline serum lipoprotein profile is related to plant stanol induced changes in serum lipoprotein cholesterol and triacylglycerol concentrations. J. Am. Coll. Nutr. 27 : 117-126.
Nguyen, T.T. (1999). The cholesterol-lowering action of plant stanol esters. J. Nutr. 129 : 2109-2112.
Nguyen, T.T. and Dale, L.C. (1999). Plant stanol esters and vitamin K. Mayo Clin. Proc. 74 : 642-643.
Noakes, M., Clifton, P., Ntanios, F., Shrapnel, W., Record, I. and McInerney, J. (2002). An increase in dietary carotenoids when consuming plant sterols or stanols is effective in maintaining plasma carotenoid concentrations. Am. J. Clin. Nutr. 75 : 79–86.
Normen, L., Dutta, P., Lia, A. and Andersson, H. (2000). Soy sterol esters and ß-sitostanol ester as inhibitors of cholesterol absorption in human small bowel. Am. J. Clin. Nutr. 71 : 908-913.
Oksana, A.M., Douglas, S.L., Mike, S., Beth, A., David, L.R., Stewart, J., and Alekel. D Lee (2002). A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men. Am. J. Clin. Nutr. 76 : 57–64.
Ortega, R.M., Palencia, A., Lo´pez-Sobaler, A.M. (2006). Improvement of cholesterol levels and reduction of cardiovascular risk via the consumption of phytosterols. Br. J. Nutr. 96(1) : 89-93.
Ostlund Jr., R.E. (2002). Phytosterols in human nutrition. Annu. Rev. Nutr. 22 : 533-549.
Otaegui-Arrazola, Menendez-Carreno, M., Ansorena, D. and Astiasaran, D. (2010). Oxysterols: a world to explore. Food Chem. Toxicol. 48 : 3289-3303.
Phillips, K.M., Ruggio, D.M. and Ashraf-Khorassani, M. (2005). Phytosterol composition of nuts and seeds commonly consumed in the United States. J. Agric. Food. Chem. 53(24) : 9436–9445.
Piironen, V. and Toivo, J. (2003). Plant sterols in vegetables, fruits and berries. J. Sci. Food Agric. 83 : 330-337.
Piironen, V., Lindsay, D.G., Miettinen, T.A., Toivo, J. and Lampi, A.M. (2000). Plant sterols: Biosynthesis, biological function and their importance to human nutrition. J. Sci. Food Agric. 80 : 939-966.
Plat, J. and Mensink, R.P. (2001). Effects of diets enriched with two different plant sterol ester mixtures on plasma ubiquinol-10 and fat-soluble antioxidant concentrations. Metabol. 50 : 520-529.
Plat, J. and Mensink, R.P. (2005). Plant stanol and sterol esters in the control of blood cholesterol levels: mechanism and safety aspects. Am. J. Cardiol. 96(1) : 15-22.
Pollak, O.J. (1953). Reduction of Blood Cholesterol in Man. Circulation. 7 : 702-706.
Qianchun, D., Yu, X., Xu, J., Liu, C., Fenghong, H., Qingde, H., and Jine, Y. (2012). Effect of flaxseed oil fortified with vitamin E and phytosterols on antioxidant defense capacities and lipids profile in rats. J. Food Sci. 77 : 135-140.
Qu?´lez, J., Rafecas, M., Brufau, G., Garc?´a-Lorda, P., Meg?´as, I. and Bullo´ M. (2003). Bakery products enriched with phytosterol esters, £tocopherol and ?carotene decrease plasma ldl-cholesterol and maintain plasma ?carotene concentrations in normocholesterolemic men and women. J. Nutr. 133 : 3103-3109.
Racette, SB, Lin, X., Lefevre, M., Spearie, C.A., Most, M.M., Ma, L. and Ostlund R.E. (2010). Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. Am. J. Clin. Nutr. 91(1) : 32-38.
Rodwell, V.W., Nordstrom, J.L., Mitschelen, J.J. (1976). Regulation of HMGCoA reductase. Adv. Lipid Res. 14 : 1-74.
Rozner, S. and Garti, N. (2006). The activity and absorption relationship of cholesterol and phytosterols. Colloids Surf. A Physicochem. Eng. Asp. 282 : 435-456.
Russell, J.C., Ewart, H.S., Kelly, S.E., Kralovec, J., Wright, J.L.C. and Dolphin P.J. (2002). Improvement of vascular dysfunction and blood lipids of insulin-resistant rats by a marine oil-based phytosterol compound. Lipids 37 (2) : 147–152.
Ryan, E., Mccarthy, F.O., Maguire, A.R., O’brien, N.M. (2009). Phytosterol oxidation products: their formation, occurrence, and biological effects of phytosterol oxidation products Food Rev. Int. 25:157-174.
Sailaja, P.S.S., Raju, M.P., Supraja, Hymavathi, T.V.N., Poshadri, A., Kuna, A. (2014). Effect of phytosterols supplemented health food (papaya fruit bar) on serum cholesterol and LDL cholesterol levels in normocholesterolemic and mildly hypercholesterolemic subjects - a pilot study. IOSR-JESTFT . 8(1): 1-8.
Salen, G., Shefer, S., Nguyen, L., Ness, G.C., Tint, G.S. and Shore, V. (1992), Sitosterolemia. J. Lipid Res. 33 : 945-955.
Salen, G., Shore, V., Tint, G.S., Forte, T., Shefer, S., Horak, I. et al. (1989). Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis. J. Lipid Res., 30 : 1319-1330.
Sanders. D.J., Minter, H.J., Howes, D. and Hepburn, P.A. (2000). The safety evaluation of phytosterol esters. The comparative absorption and tissue distribution of phytosterols in the rat. Food Chem. Toxicol., 38 : 485-491.
Shin MJ, Lee, J.H., Jang, Y., Lee-Kim, Y.C., Park, E., Kim, K.M., Chung, B.C. and Chung, N. (2005). Micellar phytosterols effectively reduce cholesterol absorption at low doses. Ann. Nutr. Metab., 49(5) : 346–351.
Sridevi, D., Ishwarlal, J. and Vega-López, S. (2004). Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. Arterioscler. Thromb. Vasc. Biol., 24 : 25-28.
Talati, R., Sobieraj, D.M., Makanji, S.S., Phung, O.J. and Coleman, C.I. (2010). The comparative efficacy of plant sterols and stanols on serum lipids: a systematic review and meta-analysis. J. Am. Diet. Assoc., 110 : 719-726.
Tikkanen, M.J. (2005). Plant sterols and stanols. Handb. Exp. Pharmacol., 170 : 215–230.
USDA (2011) US Department of Agriculture, agriculture research service, USDA nutrient database for standard reference, release27, accessed on 22 April 2015 from http://www.nal.usda.gov/fnic/foodcomp/search/
Vanmierlo, T., Husche, C., Schött, H.F., Pettersson, H., Lütjohann, D. (2013). Plant sterol oxidation products - analogs to cholesterol oxidation products from plant origin? Biochimie., 95 : 464-472.
Weihrauch, J.L. and Gardner, J.M. (1978). Sterol content of foods of plant origin. J. Am. Diet Assoc., 73 (1) : 39–47.
Wolfs, M., de Jong, N., Ocké, M.C., Verhagen, H. and Verschuren, W.M. (2006). Effectiveness of customary use of phytosterol/-stanol enriched margarines on blood cholesterol lowering. Food Chem.Toxicol., 44 (10) : 1682–1688.
Woyengo, T.A., Ramprasath, V.R. and Jones, P.J.H. (2009). Anticancer effects of phytosterols. Eur. J. Clin. Nutr., 63 : 813–820.
Wu, T., Fu, J., Yang, Y., Zhang, L. and Han, J. (2009). The effects of phytosterols/stanols on blood lipid profiles: a systematic review with meta-analysis. Asia Pac. J. Clin. Nutr., 18 (2) : 179-186.
Yvonne O’Callaghan, McCarthy, F.O., Nora M. O’Brien (2014). Recent advances in phytosterol oxidation products Biochemical and biophysical research communications. http://dx.doi.org/10.1016/j.bbrc.2014.01.148
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Plant sterols for human health- A review. (2015). Journal of Applied and Natural Science, 7(2), 1081-1087. https://doi.org/10.31018/jans.v7i2.734
