Esther Elsie. T R. D. Thilaga


Molluscs are a promising source of bioactive substances and are virtually untapped resources of novel compounds. Many novel metabolites with potent pharmacological properties have been discovered in marine organisms in recent years. The present study aimed to investigate the wound healing activity of a methanolic extract of the marine gastropod Turbinella pyrum using an excision and incision wound model. To determine the minimum lethal dose, acute oral toxicity studies were performed as per the Organization for Economic Co-operation and Development (OECD) guidelines. Excision and incision wound models were used to evaluate the wound healing activity of the methanolic extract of T. pyrum by preparing a simple ointment base BP at different concentrations using five groups of Wistar albino rats. Group I (control) received a topical application of the simple ointment BP. Group II (Standard) was treated with topical application of 5% framycetin sulphate cream, and Groups III, IV and V were treated with 5%, 10% and 15% methanolic extracts of T. pyrum. Student's t test was used to analyse the results obtained from the present study, and P<0.05 was considered significant. In the incision wound model, the epithelialization period was also found to be highly significant (P<0.05) in group V (10.77%) when compared to the standard (12.69%). In the excision wound model, the epithelialization period was also found to be highly significant (P<0.05) in group IV (13.17%) and group V (11.38%) when compared to that of the standard (Group II) (14.56%).This finding justifies that the methanolic extract of T. pyrum has properties that render it capable of promoting accelerated wound-healing activity.



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Mollusc, Pharmacology, Turbinella pyrum, Wistar albino rats, Wound healing

Ehrich, H. & Hunk, T. (1969). Effect of cortisone and anabolic steroids on tensile strength of healing wound, Annals of Surgery, 170, 2, 203–206.
Senapati, A. K., Giri, R.K., Panda, D.S. & Satyanarayan, S. (2011). Wound healing potential of Pterospermum acerifolium wild with induction of tumor necrosis factor. Journal of Basic and Clinical Pharmacy, 2, 203-206.
Badiu D. L., Balu A.M., Lucica Barbes, Rafael Luque, Roxana Nita, Marius Radu, Ecaterina Tanase & Natalia Rosoiu (2008). Physico-chemical characterization of lipids from Mytilus galloprovincialis (L.) and Rapanavenosa and their healing properties on skin burns. Lipids, 43,829–841.
Grasian Immanuel, BerkmansJudeThaddaeus, MuthusamyUsha, Ramasamy Ramasubburayan, Santhiyagu, Prakash & Arunachalam, Palavesam (2012). Antipyretic, wound healing and antimicrobial activity of procesed shell of the marine mollusc Cypraeamoneta. Asian Pacific Journal of Tropical Biomedicine, 2(3), Supplement, 2, S1643-S1646.
Jain, Roopesh,Sonawane, Shailendra &Mandrekar, Noopur (2008). Marine organisms: Potential source for drug discovery. Current Science, 94, 292
Morton, J. J. & Malone, M.H. (1972) Evaluation of vulnerary activity by an open wound procedure in rats. Arch. Int. Pharmacodyn. Ther., 196(1) 117-126.
Pandima Devi, K., Sreepriya, M., Devaki, T. & Balakrishna, K. (2003). Antinociceptive and hypnotic effects of Premna tomentosa L. (Verbenaceae) in experimental animals. Pharmacol. Biochem. Behav., 75, 261-264.
Park, J.-H., Choi, S.-H., Park, S.-J., Lee, Y.J., Park, J.H., Song, P.H., Cho, C.- M., Ku, S.-K. & Song, C.-H (2017). Promoting wound healing using low molecular weight fucoidan in a full-thickness dermal excision rat model. Mar. Drugs,  15, 112.
Srilekha V, Krishna G, Seshasrinivas and Singaracharya M.A, (2018). Evaluation of wound healing and anti-inflammatory activity of marine yellow pigmented bacterium Micrococcus sp. Indian Journal of Geo Marine Sciences. 47 (12), 2454-2464.
Subavathy P, Thilaga R.D, Bavani Saraswathy, A. & Jeyaruby S,2018. Evaluation of wound healing activity of methanolic extract of Tonna dolium (L.1758). Journal of Pharmacy, 8,3,47-51
Yadav, S., Kulshrestha, M., Goswami, M., Rao, CV., Sharma,V. 2011. Elucidation of analgesic and antipyretic activities of Ficus bengalensis linn. leaves in rats. J. App. Pharma. Sci., 01, 38-41.
Subalakshmi, M., Saranya, A., Divya, S., Kavimani, S., Murali, R., (2014). Wound healing agents from marine flora: A review. Journal of Pharma Research, 03, 13-18.
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T, E. E. ., & Thilaga, R. D. . (2022). Wound healing activity of methanolic extract of Turbinella pyrum from Gulf of Mannar, India. Journal of Applied and Natural Science, 14(1), 116–119. https://doi.org/10.31018/jans.v14i1.3130
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