Bioefficiency of Chromolaena odorata (Linn.) on hematological and lipid profiles in sublethal cyanide poisoning in male wistar rats
Chromolaena odorata is an invasive plant which is acclaimed to have cyanide remediation potential from contaminated sites. This examination means to decide the impact of ethanol concentrates of C. odorata (ECO), sodium thiosulphate and a mix of both on hematological parameters and blood lipid profile of rodents presented to potassium cyanide. (KCN). A sum of thirty five male Wistar rats partitioned into seven groups of five units were used. KCN Group rats were administered with KCN alone. Rats in 100ECO, 150ECO, 200ECO groups were administered with 100, 150 and 200 mg/kg body weight of ECO respectively. Rats under Na2sS2O3 and Na2S2O3+ECO groups were administered 200 mg/kg sodium thiosulphate and sodium thiosulphate with ECO at 200 mg/kg respectively. The trial was done in about a month. Toward the finish of the investigation, the packed cell volume (PCV), hemoglobin level (Hb), Red blood cells (RBC) and white blood cells (WBC) were resolved utilizing known biochemical methodology. The outcomes demonstrated a noteworthy increment (p ? 0.05) in PCV, Hb, RBC and WBC level of remedial groups when contrasted with the cyanide group. Total cholesterol (TC), and triglyceride (TG) were altogether lower while HDL-cholesterol was fundamentally expanded in all the treated groups when contrasted and the untreated group given cyanide alone. However, no significant difference in LDL-cholesterol was indicated in all therapeutic groups compared with the cyanide group. The study revealed that C. odorata at the tested doses was able to improve the hematological parameters and lipid profile in cyanide exposed rats.
Cyanide, Hematology, Lipid profile, Rats, Chromolaena odorata
Julius Cuong Pham, David T Huang, Francis T McGeorge, and Emanuel P Rivers, “Clarification of cyanide’s effect on oxygen transport characteristics in a canine model,” 2007.
“Bhattacharya, R. and Tulsawani, R. (2009). Protective role of ?-ketoglutarate against massive doses of cyanide in rats. Environ. Biol. 30(4): 515-520.”
Kadiri, H.E, “The Effects of Aqueous Vernonia Amygdalina (Bitter Leaf) Extract On The Lipid Profile And Some Hematological Parameters In Rats Exposed To Cyanide,” 2017.
“Baskin, S.I., Porter, D.W., Rockwood, G.A., Romano, J.A., Patel, H.C., Kiser, R.C., Cook, C.M. and Ternay, A.L. (1999). In vitro and in vivo comparison of sulfur donors as antidotes to acute cyanide intoxication. J. Appl. Toxicol. 19: 173–183.”
Olusola Ladokun, Matthew Ojezele, and Oluwatosin Arojojoye (2015), “Comparative study on the effects of aqueous extracts of viscum album (mistletoe) from three host plants on hematological parameters in albino rats,”.
Joshi PK, Bose M, and Harish D., (2002). Haematological changes in the blood of Clarias battrachus exposed to mercuric chloride. Ecotoxicol Environ Monit., 12: 119–122
Sunmonu TO, Oloyede OB., (2010). Performance and haematological indices in rats exposed to monocrotophos contamination. Hum Exp Toxicol. 29(10):845–850
Okonkwo JE, Iyadi KC, Effiong CO., (2004). Effect of chronic administration of haematological parameters of rats. Nig J Physiol Sc., 19(1–2):10–13.
M. Aminlari, S. Gholami, T. Vaseghi, and A. Azarafrooz, (1997). Rhodanese (thiosulfate: cyanide sulfurtransferase) in the digestive tract of chicken at different stages of development, Poultry Science, 76 (2) 318–320
Akinmoladun A C and Akinloye, (2007). Effect of Chromolaena odorata on hypercholesterolemia related metabolic imbalances. Proc. Akure-Humbold Kellog/3rd SAAT Annual Conference, FUTA, Nigeria, 287-290
Odugbemi T, (2006). Outlines and pictures of medicinal plants from Nigeria. University of Lagos Press, Lagos, Nigeria, Pp. 1-283
Akinrotimi OA, Abu OMG, Ansa EJ, Edun OM, George OS., (2009). Hematological responses of Tilapia guineensis to acute stress. Int. J. Nat. Appl Sci., 5:338-348.
Anusuya, B. and Sumathi, S. (2015). Haematological Alterations Due to Typhoid Fever in Mayiladuthurai Area, Nagapattinam. International Journal of Research in Pharmacology and Pharmacotherapeutics, 4: 210-216
Das, B.K. and Mukherjee, S.C. (2003). Toxicity of Cypermethrin in Labeorohita Fingerlings: Biochemical Enzymatic and Haematological Consequence. Comparative Biochemistry and Physiology Part C?: Pharmacology, 134: 109-121. https://doi.org/10.1016/S1532-0456(02)00219-3
Joshua Charles Isirima, Iyeopu Minakiri Siminialayi, (2015). Effect of Chromolaena odorata Extracton Hematotoxicity and Spleen Histopathology Induced by Salmonella typhi in Wistar Rats,
Dangana, A., Ajobiewe, J. and Nuhu, A. (2010). Hematological Changes Associated with Salmonella typhi and Salmonella paratyphi in Humans. International Journal of Biomedical Science, 6: 219-222
Ehigie O. L., Okonji R. E., Ehigie F. A., Olapeju A.O. and Fagbohunka B.S (2015). Purification and characterization of rhodanese from the leave of bitter melon (Momordica charantia). International Journal of Research in Applied, Natural and Social Sciences 3: 47-58
Ehigie Ona Leonard, Adeola Folashade Ehigie, Mohammed Adewumi Abdulrasak and Fiyinfoluwa D. Ojeniyi (2019). Kinetic properties of rhodanese from African locust bean seeds (Parkia Biglobosa). Asian Journal of Biomedical and Pharmaceutical Sciences, 9 ( 67): 18-23
Ola-Mudathir and Maduagwu, Emmanuel, (2015). Effects of Alium cepa Linn on rhodanese activities and half-life of cyanide in the blood. Int. J. Biol. Chem. Sci. 9(2): 1004-1012
Owoade O., A. Adetutu, S. O. Olorunnisola, and O. Ogundipe (2019). Investigation of Hepatoprotective and Antioxidant Activity of Celosia argentea against Tissue Injury Caused by Rifampicin Administration. Journal of Applied Life Sciences International 19(4): 1-11
John Esben Kirk, (1969). Enzymes of the Arterial Wall. Academic Press. ISBN: 978-1-4832-3177-8 DOI:10.1016/C2013-0-12424-5
Krueger, K. Koch, A. Jühling, M. Tepel, and A. Scholze, (2010). Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients,” Clinical Biochemistry, 43 (1): 95–101
Ojeniyi F.D., Ehigie A.F., Ehigie O.L., (2019) Evaluation of Enzymatic Changes in Sublethal Cyanide Poisoning in Wistar Rats Treated with Chromolaena odorata (Linn.) and Sodium Thiosulphate. J Plant Biochem Physiol. 7:242. DOI: 10.35248/2329-9029.19.7.242
This work is licensed under Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) © Author (s)