The effect of adrenelectomy was studied on the antioxidant metabolism in different tissues (Liver, heart, kidney and muscle) of rat. G-6-PDH was increased significantly in liver and heart and the same was decreased in kidney with a non significant change in muscle. SOD was significantly increased in heart and muscle. Catalase was significantly decreased in liver and muscle and was increased significantly in kidney. XOD showed significant decrease in liver and increase in heart, kidney and muscle. The present finding, in general, exhibit tissue specific
alterations in free radical metabolism in conjunction with antioxidant defence mechanisms during adrenal hormone deficiency. It is also clear from the results that the mechanisms involved in selective activation / inhibition of different pathways seems to reflect multifaceted physiological adaptations as a compensatory measure during induced adrenalectomy.
Adrenalectomy, Antioxidant metabolism, Sham operated, Tissue
Bhaskar M., Stith R.D., Brackett D.J., Wilson M.F., Learner M.R and Reddy Y.S. (1989). Changes in myocardial ATPases in chronically adrenalectomized rats with and without glucocorticoid replacement. Biochem. Med. Metabol. Bio., 42: 118 â€“ 124.
Dellacorte, E. and Stnipe, F. (1972). The regulation of liver xanthine oxidase involvement of the thiol groups in the conversion of the enzyme activity from dehydrogenase into oxidase (type 0) and purification of the enzyme. Biochem J., 126: 739-745.
Halliwell,B. and Gutteridge, J.M.C. (1989). Free Radicals in Biology and Medicine. 2nd edition UK, Oxford, Clarendon.
Helmutsies. (1985) In : oxidative stress (Helmut Sies ED) Academic press, New York, pp.22-25.
Hussain, K. (2002). Exercise conditioning attenuates the hypertensive effects of nitric oxide synthase inhibitor in rat. Mol. Cell. Biochem., 231 (1-2) : 129-137.
Husain, K. (2003). Interaction of exercise training and chronic NOS inhibition on blood pressure, heart rate, NO and antioxidants in plasma of rats. Pathophysiology, 10 (1):47-56.
Husain, K. and Hazelrigg, S.R. (2002). Oxidative injury due to chronic nitric oxide synthase inhibition in rat: effect of regular exercise on the heart. Biochem. Biophys. Acta., 1587(1): 75-82.
Jacob, R.A. and Burri, B.J. (1996). Oxidative damage and defense. Am. J. Clin. Nutr., 63 (6) : 985S-990S.
Kaul, L. and Berdanier, C.D. (1975). Effect of pancreatectomy or adrenalectomy on the responses of rats to meal-feeding. J. Nutr., 105 (9) : 1176-85.
Kono, Y. and Fridovich, I. (1982). Superoxide radical inhibits catalase. J. Boil. Chem., 257: 5751.
Nelson, D.H. and Ruhmann-Wennhold, A. (1975). Corticosteroids increase superoxide anion production by rat liver microsomes. J. Clin. Invest., 56 (4): 1062-5.
Parfenova, N.S. and Shanygina, K.I.(1976). Nature of changes in the activity of certain enzymes of energy metabolism in the liver after partial sympathectomy. Vopr. Med. Khim., 22 (6) : 08-12.
Piegeolet, E. and Corbisier, P. (1990). Glutathione peroxidase and superoxide dismutase and catalase inactivation by AO. Mech. Age. Dev.,51: 283.
Powers, S.K., DeRuisseau, K.C., Quindary, J. and Hamilton, K.L. (2004). Dietary antioxidants and exercise. J. Sports Sci., 22: 81-94.
Schroder, H., Navarro, E., Mora, J., Galiano. D. and Tramullas. A. (2001). Effects of Ã¡-tocopherol, Ã¢-carotene and ascorbic acid on oxidative, hormonal and enzymatic exercise stress markers in habitual training activity of professional basket ball players. Eur. J. Nutr., 40 (4) : 178-84.
Skibba,J., Power, R., Stamdnicka, A. and Kalinfleisch, J. (1988). Lipid peroxidation after hyperthermic perfusion of rat liver. FASEB J. 12(A376) Medical college Wison, Milwankee, W.S. 3226 and Zablock: Veterans administration, Milwankee, W. 153/98.
Somani, S.M. and Arroyo, C.M. (1995). Exercised training generates ascorbate free radicals in rat heart. Indian J. Physiol. Pharmacol., 39 (4) : 323-329.
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