Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model and pylorus ligation model, respectively. Additionally, the extract also prohibited the formation of haemorrhage and edema, significantly lessened catalase activity (p<0.0001) and the lipid peroxidation level (p<0.0001) in the glandular tissue of Wistar albino rats. Furthermore, the extract also significantly diminished the total acidity(p<0.0001) of the gastric fluid by increasing its pH (p<0.0001). The occupancy of different phytoconstituents in the extract, such as flavonoids and tannins were identified that may be responsible for its gastro-protective activity. All these results provide a basis explaining the antiulcer ability of A. procera being useful in the management of gastric ulcers.
Antiulcer, Gastroprotective, Pylorus-ligation, Safed siris, Ulcer index
Akhtar, M.S., Akhtar, A.H., and Khan, M.A. (1992). Antiulcerogenic effects of Ocimum basilicum extracts, volatile oils and flavonoid glycosides in albino rats. Int. J. Pharmacogn,30(2), 97-104. https://doi.org/10.3109/1388020920 9053966
Alvarez-Suarez, J.M., Dekanski, D., Risti?, S., Radonji?, N.V., Petronijevi?, N.D., Giampieri, F., Astolfi, P., Gonzalez-Paramas, A.M., Santos-Buelga, C., Tulipani, S., and Quiles, J.L. (2011). Strawberry polyphenols attenuate ethanol-induced gastric lesions in rats by activation of antioxidant enzymes and attenuation of MDA increase. PLoS One, 6(10): e25878. https://dx.doi.org/10.1371%2Fjournal.pone.0025878
Ambika, K., and Jegadeesan, M. (2017). Antiulcer activity of A. procera leaves in different growth phases. Int J Innov Res Sci Eng Technol, 6(9), 19495-19499. DOI:10.15680/IJIRSET.2017.0609149
Ariypshi, I. (1986). Recurrence during maintenance therapy with histamine H2 receptors antagonists in cases of gastric ulcers. Nikon Univ J Med, 28, 69-74.
Azamthulla, M., Balasubramanian, R., and Kavimani. (2015). A review on medicinal plants exhibiting antifertility activity. WJPPS, 4(3), 243- 72.
Brzozowski, T., Konturek, P.C., Konturek, S.J., Kwiecien, S., Pajdo, R., Brzozowska, I., and Hahn, E.G. (1998). Involvement of endogenous cholecystokinin and somatostatin in gastroprotection induced by intraduodenal fat. J. Clin. Gastroenterol,27(1), S125-137. https://doi.org/10.1016/s0167-0115(99)00029-4
Buege, J.A., and Aust, S.D. (1978). Microsomal lipid peroxidation Method. Enzymol, 52(1):302-310. https://doi.org/10.1016/S0076-6879(78)52032-6
Dwivedi, V., Chander, B.S., and Yadav, N.H. (2014). Evaluation of antiulcer activity of Clitorea ternatea Leaves (Linn) extract in Wistar rats. Indian J. Biotech. Pharm. Res, 3,1225–29.
Kedare, S.B., and Singh, R.P. (2011). Genesis and development of DPPH method of antioxidant assay. Int J Food Sci Tech, 48(4), 412-22. https://dx.doi.org/10.1007%2 Fs13197-011-0251-1
Khandelwal, K.R. (2002). Practical Pharmacognosy, Technique and Experiments, 9th ed. Nirali Prakashan, 23.10-23.11, pp 25.1-25.6.
Kokate, C.K., Purohit, A.P., and Gokhle, S.B. (2015). Pharmacognosy, 51st ed. Nirali Prakashan, Pune, pp7.16-7.18.
Kokila, K.A., Priyadharshini, S.D., Sujatha, V. (2013). Phytopharmacological properties of Albizia species: A Review. International Journal of Pharmacy and Pharmaceutical Sciences, 5:70-73.
Khatoon, M.M., Khatun, M.H., Islam, M.E., Parvin, M.S. (2014). Analgesic, antibacterial and central nervous system depressant activities of Albizia procera leaves. Asian Pacific Journal of Tropical Biomedicine, 4:279-84.
Kumar, S.K., Mruthunjaya, K., and Mythreyi, R. (2013). Antiulcer activity of ethanol extract of the stem bark of Carea arborea Roxb. Int. Curr. Pharm. J, 2(3):78 http://dx.doi.org/10.3329/icpj.v2i3.13633
Misra, V., Yadav, G., Uddin, S.M., and Srivastava, V. (2012). Determination of antiulcer activity of Plumeria Rubra leaves extract. Int. Res. J. Pharm, 3(9),194-197.
Pekal, A., and Pyrzynska, K. (2014). Evaluation of aluminium complexation reaction for flavonoid content assay. Food Analytical Methods, 7(9),1776-82. https://doi.org/10.1007/s12161-014-9814-x
Pillai, N.R., Suganthan, D., Seshari, C., and Santhakumari G. (1978). Antigastric ulcer activity of nimbidin. Indian J Med Res, 68,169-175.
Prabha, T., Babu, M.D., Priyambada, S., Agrawal, V.K., and Goel, R.K. (2003). Evaluation of Pongamia pinnata root extract on gastric ulcers and mucosal offensive and defensive factors in rats. Indian Journal of Experimental Biology, 41(03), 304-310.
Ruchi, M., & Rekha, V. (2017). Determination of total flavonoid and Phenol content in Mimusops elengi Linn. International Journal of Pharmaceutical sciences & Research,8(12), 5282-5285. DOI: 10.13040/IJPSR.0975-8232.8(12).5282-85
Saranya, P., Geetha, A., Selvamathy, S.N. (2011) A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer. Indian journal of pharmaceutical sciences. 73(5), 550.
Sivakrishnan, S., & Swamivelmanickam (2019). A comprehensive review on Albizzia procera (Roxb.) Benth. An update. Indian Journal of Pharmaceutical Science and Research,10(9), 4129-4144.
Srivastava, V., Viswanathswamy, A.H.M., and Mohan, G. (2010). Determination of the antiulcer properties of Sodium cromoglycate in albino rats. Indian J. Pharmacol, 42,185-188. https://DOI: 10.4103/0253-7613.66844
Waldum, H.L., Hauso, O and Fossmark R. (2013). The regulation of gastric acid secretion- clinical perspectives. Acta Physiologica, 210(2), 239-256.
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