The effect of P-alaxin on some neurobehavioural parameters was studied in Swiss white mice. 21 mice were randomly assigned to three groups (n=7) namely; control group, clinical dose group and high dose group. Animals in control group received normal rat chow and standard feed ad libitum. Animals in the clinical dose group were given P-alaxin at a dose of 0.01mg/kg body weight while animals in the high dose group were given P-alaxin at a dose of 0.02mg/kg body weight. The results obtained showed that, in the open field maze test, the clinical dose and high dose groups showed significant increase (P<0.05) in stretch attend posture compared to control. Conversely, there was a significant decrease (P<0.05) in line crossings of high and clinical dose groups when compared to control. In the light/dark transition box test, the clinical and high dose groups showed a significant decrease (P<0.05) in the frequency of line crossings when compared to control. In the morris water maze test, the high and clinical dose groups showed a significant inncrease in frequency of swimming latency when compared to control group. From the total analysis obtained, P-alaxin decreases locomotion and exploratory activities, it impairs motivation and the tendency to investigate the environment as well as reduction in visuospartial learning and memory.
P-Alaxin, Dihydroartemisinin, Piperaquine phosphate, Neurobehaviour
Bisong, S. A., Nku, O., Nwoke, U. and Osim, E. (2018). Crude aqueous leave extract of carica papaya linn (pawpaw) reduced anxiety and fear related behaviour in cd1 mice. European journal of pharmaceutical and medical research. 5(3): 488-493
Bisong, S. A., Okon, U. A., Chukwu, J. A. O., Sanya, O. A., Akinnuga, M. A. and Unirere, G. N. (2017). Long term consumption of coconut oil diet increased anxiety related behaviour in CD1 mice. Journal of Complementary and Alternative Medical Research. 2(1):1-13
Bourin, M. H. and Hascoet, M. H (2003). The mouse light/dark box test. European Journal of Pharmacology, 463: 55-65
Cabello, C. M., Lamore, S. D., Bair, W. B., Qiao, S., Azimian, S., Lesson, J. L. and Wondrak, G.T. (2012). The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis. Investigational new drugs, 30(4):1289-1301
Chapillon, P. F. and Debouzie, A. B. (2000). BALB/C mice are not so bad in the Morris water maze. Behavioural Brain Research, 117: 115-118.
Chi, K. J. and Schmitt, D. (2005). Mechanical energy and effective foot mass during impact loading of walking and running. Journal of biomechanics, 38(7): 1387-1395.
Dalm, S., Grootendorst, J., De Kloet, E. R. and Oitzl, M. S. (2000). Quantification of swim patterns in the Morris water maze. Behavior Research Methods, Instruments, and Computers, 32(1): 134-139.
Gallagher, B.F. (2008). Fear of the unknown. Safer Communities, 7(3): 22-24.
Morris, R. B. (1984). Development of procedure for studying spatial learning in the mice. Journal of Neuroscience Method, 11: 47-60.
Sandi C. E. (2001). Healing anxiety disorders with glucocorticoids. Proceedings of the National Academy of Sciences, 108(16): 6343-6344.
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